Detalhe da pesquisa
1.
Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection.
Proc Natl Acad Sci U S A
; 120(11): e2219523120, 2023 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36893269
2.
RNAi-based modulation of IFN-γ signaling in skin.
Mol Ther
; 30(8): 2709-2721, 2022 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35477658
3.
Innovative developments and emerging technologies in RNA therapeutics.
RNA Biol
; 19(1): 313-332, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35188077
4.
Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles.
Mol Ther
; 29(4): 1382-1394, 2021 04 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33348054
5.
The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy.
Nucleic Acids Res
; 48(14): 7665-7680, 2020 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32672813
6.
Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo.
Nucleic Acids Res
; 47(3): 1082-1096, 2019 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30544191
7.
Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways.
Nucleic Acids Res
; 47(3): 1070-1081, 2019 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30535404
8.
Hydrophobicity of Lipid-Conjugated siRNAs Predicts Productive Loading to Small Extracellular Vesicles.
Mol Ther
; 26(6): 1520-1528, 2018 06 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29699940
9.
Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles.
Mol Ther
; 26(8): 1973-1982, 2018 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29937418
10.
Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier.
Mol Ther
; 26(11): 2580-2591, 2018 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30143435
11.
A 2',2'-disulfide-bridged dinucleotide conformationally locks RNA hairpins.
Org Biomol Chem
; 16(17): 3181-3188, 2018 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29645048
12.
Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in Mouse Brain.
Bioconjug Chem
; 28(6): 1758-1766, 2017 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28462988
13.
Lipophilic 2'-O-Acetal Ester RNAs: Synthesis, Thermal Duplex Stability, Nuclease Resistance, Cellular Uptake, and siRNA Activity after Spontaneous Naked Delivery.
Chembiochem
; 17(21): 2054-2062, 2016 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27569765
14.
A versatile post-synthetic method on a solid support for the synthesis of RNA containing reduction-responsive modifications.
Org Biomol Chem
; 14(29): 7010-7, 2016 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27356960
15.
Synthesis, binding, nuclease resistance and cellular uptake properties of 2'-O-acetalester-modified oligonucleotides containing cationic groups.
Bioorg Med Chem
; 23(17): 5360-8, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26260340
16.
Direct synthesis of partially modified 2'-O-pivaloyloxymethyl RNAs by a base-labile protecting group strategy and their potential for prodrug-based gene-silencing applications.
Chembiochem
; 15(18): 2674-9, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25346406
17.
Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in mouse and pig photoreceptors.
Mol Ther Nucleic Acids
; 35(1): 102088, 2024 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38192611
18.
Therapeutic Oligonucleotides: An Outlook on Chemical Strategies to Improve Endosomal Trafficking.
Cells
; 12(18)2023 09 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37759475
19.
Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in rodent and swine photoreceptors.
bioRxiv
; 2023 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37790464
20.
Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin.
Nat Commun
; 14(1): 7099, 2023 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37925520