Three dimensional gait analysis in patients with symptomatic component mal-rotation after total knee arthroplasty.

PURPOSE: Purpose of the present cohort study was the determination of lower body function and rotation in patients with symptomatic component mal-rotation after total knee arthroplasty using instrumented 3D gait analysis. METHODS: A consecutive series of 12 patients (61.3 years ± 11.4 years) were included suffering under remaining pain or limited range of motion at least six months after total knee arthroplasty. A CT-scan according to the protocol of Berger et al. and instrumented 3D gait analysis were carried out including clinical examination, videotaping, and kinematic analysis using a Plug-in Gait model. Outcome variables were temporospatial parameters as well as kinematics in sagittal and transversal plane. Data for reference group were collected retrospectively and matched by age and gender. RESULTS: Temporospatial parameters of the study group showed decreased velocity, cadence, and step length as well as increased step time. Single limb support was reduced for the affected limb. In sagittal plane, maximum knee flexion during swing phase was reduced for the replaced knee joint. In transverse plane, there was hardly any difference between affected and non-affected limb. Compared to the reference group, both limbs show significant increased internal ankle rotation and external hip rotation. There were significant strong linear correlations between ankle rotation and hip rotation as well as ankle rotation and radiological tibial mal-rotation. CONCLUSIONS: Patients with symptomatic component mal-rotation after total knee arthroplasty showed typically functional deficits. The affected and non-affected limb showed significant increased internal ankle rotation and external hip rotation, while only the affected, replaced knee showed reduced internal knee rotation. Identification of rotational abnormalities of hip and ankle joints seems to be mandatory in TKA to identify the patient group with external hip rotation, internal ankle rotation, and an elevated risk for symptomatic rotational TKA component mal-alignment.

Treatment of High-Grade Acetabular Defects: Do Porous Titanium Cups Provide Better Stability Than Traditional Titanium Cups When Combined With an Augment?

BACKGROUND: Revision total hip arthroplasty frequently faces challenges associated with deficient bone stock. Porous metal implants were developed to meet the challenge, but require rapid osseointegration for ultimate success. This study aims to assess relative motion as an indicator for primary stability and osseointegration of two different titanium cups each combined with a titanium augment. METHODS: In 14 cadaver hemipelvises, 2 types of titanium acetabular cups, a traditional sintered-bead cup (POROCOAT Acetabular Cup [PAC]) and a newer porous-coated cup (GRIPTION Acetabular Cup [GAC]) each associated with a porous augment, were subjected to 3-dimensional varying loads, replicating 30% of loads experienced during normal gait. Relative motion was measured at the cup/bone, augment/bone, and cup/augment interfaces. RESULTS: Only at the cup/bone interface was there a statistically significant difference in relative motion between the traditional PAC and the newer GAC, with PAC showing less relative motion (P = .0037). Bone mineral density (BMD) had a significant effect on relative motion (P = .0019) at the cup/bone interface of both cup types, with low BMD specimens showing more relative motion. CONCLUSION: Both cup types combined with augments displayed minimal relative motion that was within the accepted range thought to allow osseointegration, although the traditional surface proved superior to the newer surface. This difference was more pronounced at low BMD, with the well-established PAC cup displaying less relative motion than the more porous GAC cup, consistent with better osseointegration than the more porous cup. This suggests that the more porous implant may be less advantageous than traditional PAC cups, particularly in cases with poorer bone stock.

Comparison of the Primary Stability of a Porous Coated Acetabular Revision Cup With a Standard Cup.

BACKGROUND: The number of revision hip arthroplasty procedures has been increasing substantially, with the acetabular component requiring component revision in over half of the cases. New porous implant designs attempt to improve outcomes due to improved osseointegration; however, sufficient primary stability is paramount for good osseointegration. METHODS: We compared 2 revision cups of the same geometry, yet different surface properties in an in vitro scenario: a porous titanium surface and a conventional sintered-bead titanium surface. These were tested in 10 cadaveric pelvises under a physiologic cyclic partial weight-bearing scenario. Each side was randomly implanted with one of the implants. Relative motion between the bone and cup was measured using an optical measuring device. Statistical evaluation was carried out descriptively using a covariance analysis with repeated measures and a test of fixed effects, with significance determined as P < .05. RESULTS: The conventional cup displayed an average relative motion of 28.02 µm; and the porous implant displayed an average relative motion of 33.42 µm. There was no statistically significant difference between the two with regard to the resultant relative motion (P = .2649). The bone mineral density does have a significant influence on resultant relative motion (P = .0406), with higher bone mineral density correlating with less relative motion in both implants. CONCLUSION: The porous implant provides similar primary stability to the conventional implant in the tested scenario; the motion of both implants relative to the bone was within safe limits for osseointegration. Bone stock must be considered when choosing implant type and postoperative care.

Treatment of severe bone defects during revision total knee arthroplasty with structural allografts and porous metal cones-a systematic review.

Aseptic loosening and focal osteolysis are the most common reasons for knee arthroplasty failure. The best treatment remains unclear. We reviewed the literature on the treatment of revision knee arthroplasty using bony structural allografts (476 cases) and porous metal cones (223 cases) to determine if a difference in the revision failure rates was discernable. The failure rates were compared using a logistic regression model with adjustment for discrepancies in FU time and number of grafts used (femoral, tibial, or both). In this analysis, the porous implant shows a significantly decreased loosening rate in AORI 2 and 3 defects. The overall failure rate was also substantially lower in the porous metal group than the structural allograft group; little difference in the infection rates was noted.

Loosening after acetabular revision: comparison of trabecular metal and reinforcement rings. A systematic review.

The best method of revision acetabular arthroplasty remains unclear. Consequently, we reviewed the literature on the treatment of revision acetabular arthroplasty using revision rings (1541 cases; mean follow-up (FU) 5.7 years) and Trabecular Metal, or TM, implants (1959 cases; mean FU 3.7 years) to determine if a difference with regard to revision failure could be determined. Failure rates of the respective implants were compared statistically using a logistic regression model with adjustment for discrepancies in FU time. In our study, TM shows statistically significant decreased loosening rates relative to revision rings for all grades including severe acetabular defects and pelvic discontinuity. The severe defects appear to benefit the most from TM.

The protective effect of pulsed lavage against implant subsidence and micromotion for cemented tibial unicompartmental knee components: an experimental cadaver study.

Cemented UKAs were performed in 12 pairs of human cadaver legs and the bone bed was cleansed using pulsed lavage (group A) and conventional syringe lavage (group B). Subsidence and micromotion of the loaded tibial trays were measured. There was a significant effect of BMD on subsidence (P = 0.043) but not on micromotion. Cement penetration of group A was significantly increased (P = 0.005). Group A showed a reduced implant subsidence (P = 0.025) and micromotion (P = 0.026) compared to group B. The group differences in micromotion and implant subsidence of UKA tibial components were statistically significant but rather small and might clinically be of minor importance. Nevertheless a worse bone quality adversely affected implant subsidence and pulsed lavage had a protective effect in these specimens.

Mechanical properties of a cemented porous implant interface.

BACKGROUND: Revision arthroplasty often requires anchoring of prostheses to poor-quality or deficient bone stock. Recently, newer porous materials have been introduced onto the market as additional, and perhaps better, treatment options for revision arthroplasty. To date, there is no information on how these porous metals interface with bone cement. This is of clinical importance, since these components may require cementing to other prosthesis components and occasionally to bone. METHODS: We created porous metal and bone cylinders of the same size and geometry and cemented them in a well-established standardized setting. These were then placed under tensile loading and torsional loading until failure was achieved. This permitted comparison of the porous metal/cement interface (group A) with the well-studied bone/cement interface (group B). RESULTS: The group A interface was statistically significantly stronger than the group B interface, despite having significantly reduced depth of cement penetration: it showed a larger maximum tensile force (effect size 2.7), superior maximum tensile strength (effect size 2.6), greater maximum torsional force (effect size 2.2), and higher rotational stiffness (effect size 1.5). INTERPRETATION: The newer porous implants showed good interface properties when cemented using medium-viscosity bone cement. The axial and rotational mechanical strength of a porous metal/cement interface appeared to be greater than the strength of the standard bone/cement interface. These results indicate that cementing of porous implants can provide great stability in situations where it is needed.

Tibial cementing in UKA: a three-dimensional analysis of the bone cement implant interface and the effect of bone lavage.

Loosening is a common cause for revision in cemented UKA. In a cadaver study, we analyzed the three-dimensional cement distribution under the tibial implant and the effect of bone lavage (pulsed lavage, syringe lavage) on maximum cement penetration and penetration volume. Analyses were determined by performing bone cuts in medio-lateral direction and converting this data into a 3D model. Pulsed lavage led to an increased mean maximum cement penetration 5.79 ± 2.63 mm and penetration volume 6471.34 ± 1156.43 mm(3) compared to syringe lavage 4.62 ± 2.61 mm, 5069.81 ± 1177.09 mm(3) (P<0.001; P<0.001). Our results show a complete cement mantle for both investigated lavage techniques. Cleansing the cancellous tibial bone bed using pulsed lavage is more effective than conventional syringe lavage and leads to a deeper cement penetration and lager cement penetration volume under the tibial component.

What is the upper limit of cement penetration for different femoral hip resurfacing components?

We used a validated femoral resurfacing model to obtain measurements of pressure and temperature and quantify cement distribution as a function of inner geometry and cementing technique of five different femoral hip resurfacing components. The purpose was to investigate if manufacture cementing recommendations are reliable. ASR showed only with the recommended manual cementing technique low cement pressures of 58.0±50.2kPa and low interface temperatures of 33.3±4.1°C. BHR had large cement defects of 10.4±1.1mm. Conserve Plus caused the smallest cement penetration depths of 2.9±0.6mm. Durom was tolerant against changes of the cementing technique but showed the widest spread of temperature data 42.8±7.0°C. ReCap showed the highest risk for incomplete seating with a cement mantle thickness of 4.3±0.9mm. Polymerization heat did not exceed the threshold of 45°C with a cement penetration depth of less than 4.2mm in any circumstances of this study.

Good accuracy of the Phase III Oxford Mobile Bearing Unicompartmental Knee Instrumentation.

BACKGROUND AND PURPOSE: Unicompartmental knee arthroplasty (UKA) needs careful balancing of flexion/extension (F/E) gaps to prevent dislocation of the mobile meniscal bearing. Assessment of gaps is based on the surgeon's subjective insertion force of a feeler gauge with different thicknesses and/or the lift-off of a trial meniscal bearing. However, the accuracy of this method remains unclear. We assessed the accuracy of the technique. PATIENTS AND METHODS: A consecutive series of 33 UKAs in 32 patients (mean age 64 years, 24 women) were balanced using the Oxford Phase III (OP III) Instrumentation. The recommended technique for F/E gap assessment was performed using different feeler gauges with 1-mm increments and the meniscal bearing lift-off tests according to surgical technique. A tensiometer was inserted and both gaps were maximally distracted by hand. Measurements in mm were recorded and analyzed with a reading of 90 N for both gaps in 20 and 90 degrees of flexion. RESULTS: The gaps measured were 12 (11-18) mm in extension and 13 (11-18) mm in 90 degrees of flexion. The difference between the gaps was 0.4 (-0.5 to 1.0) mm (p < 0.001). There were no statistically significant gender differences regarding composite implant thickness, laxity, flexion gap, extension gap, or gap difference. INTERPRETATION: OP III instrumentation using feeler gauges and the lift-off test provides accurate balancing of F/E gaps with an accuracy of less than 1 mm.

Pulsatile Lavage Improves Tibial Cement Penetration and Implant Stability in Medial Unicompartmental Arthroplasty: A Cadaveric Study.

Cemented unicompartmental knee arthroplasty (UKA) shows good survivorship and function. However, implant failure, causing the need for revision, can occur. Aseptic loosening is still among the most common reasons for revision. The purpose of this study was to assess the influence of preimplantation lavage technique on tibial cement penetration depth, tibial cement volume, and load to fracture in the tibial component of mobile-bearing UKA. In 10 pairs of fresh frozen human tibiae, cemented UKA was implanted by an experienced surgeon. Tibial components were then implanted, left and right tibiae were randomly allocated to group A or B. Prior to implantation, irrigation was performed with either syringe lavage or pulsatile jet lavage in a standardized manner. Cement surface was 4170.2 mm2 (3271.6-5497.8 mm2) in the syringe lavage group, whereas the jet lavage group showed 4499.3 mm2 (3354.3-5809.1 mm2); cement volume was significantly higher as well (4143.4 mm3 (2956.6-6198.6 mm3) compared with 5936.9 mm3 (3077.5-8183.1 mm3)). Cement penetration depth was 2.5 mm (1.7-3.2 mm) for the jet lavage, and 1.8 mm (1.2-2.4 mm) for the syringe lavage. The mean fracture load was 4680 N in the jet lavage group and 3800 N in the syringe lavage group (p = 0.001). Subsidence was significantly higher for syringe lavage. This study suggests a correlation of cement penetration depth and cement volume to implant failure in the tibial component of a UKA using a cadaveric model. The type of bone lavage most likely influences these two key parameters.

The influence of the femoral force application point on tibial cementing pressure in cemented UKA: an experimental study.

BACKGROUND: Aseptic loosening is the major cause for implant failure in cemented unicompartmental knee arthroplasty (UKA). Central positioning of the femoral pressure during the tibial cementation process is recommended to achieve equal pressure and a good cementation result. The aim of this study was to verify the central position of the femoral force application point (FFAP) at 45° flexion of the knee and to investigate the influence of ligament tension and cement penetration pressure (CPP) for UKA. MATERIALS AND METHODS: Cemented Oxford UKAs were performed in 24 human legs. CPP and ligament tension forces (LTF) were measured. The FFAP was measured in a standardised manner in relation to the tibial implant length on lateral digital X-rays. RESULTS: The FFAP at 45° of knee flexion is located at 53.5 % and is not significantly different from the FFAP at 0° (p = 0.768). The CPP shows mean values at the anterior portion of 13.97 kPa (SD 16.11), at the implant keel of 24.34 kPa (SD 25.21) and at the posterior portion of 36.58 kPa (SD 26.51). The LTF shows a mean value of 194.35 N (SD 83.77). CONCLUSION: The central position of the FFAP for the investigated cemented UKA with single radius femoral component at 45° flexion of the knee could be confirmed. A flexion angle of <45° does not influence the position of the FFAP significantly. More than 45° of flexion should be avoided because the FFAP shifts backwards significantly and may cause increased pressures posteriorly and therefore tilting of the component occurs during the cementation process.

The primary stability of the femoral component in cemented single and twin peg Oxford unicompartmental knee arthroplasty under adverse conditions.

AIMS: The cemented Oxford unicompartmental knee arthroplasty (OUKA) features two variants: single and twin peg OUKA. The purpose of this study was to assess the stability of both variants in a worst-case scenario of bone defects and suboptimal cementation. METHODS: Single and twin pegs were implanted randomly allocated in 12 pairs of human fresh-frozen femora. We generated 5° bone defects at the posterior condyle. Relative movement was simulated using a servohydraulic pulser, and analyzed at 70°/115° knee flexion. Relative movement was surveyed at seven points of measurement on implant and bone, using an optic system. RESULTS: At the main fixation zone, the twin peg shows less relative movement at 70°/115°. At the transition zone, relative movements are smaller for the single peg for both angles. The single peg shows higher compression at 70° flexion, whereas the twin peg design shows higher compression at 115°. X-displacement is significantly higher for the single peg at 115°. CONCLUSION: Bony defects should be avoided in OUKA. The twin peg shows high resilience against push-out force and should be preferred over the single peg. Cite this article: Bone Joint Res 2022;11(2):82-90.

Does tibial design modification improve implant stability for total knee arthroplasty? An experimental cadaver study.

AIMS: One of the main causes of tibial revision surgery for total knee arthroplasty is aseptic loosening. Therefore, stable fixation between the tibial component and the cement, and between the tibial component and the bone, is essential. A factor that could influence the implant stability is the implant design, with its different variations. In an existing implant system, the tibial component was modified by adding cement pockets. The aim of this experimental in vitro study was to investigate whether additional cement pockets on the underside of the tibial component could improve implant stability. The relative motion between implant and bone, the maximum pull-out force, the tibial cement mantle, and a possible path from the bone marrow to the metal-cement interface were determined. METHODS: A tibial component with (group S: Attune S+) and without (group A: Attune) additional cement pockets was implanted in 15 fresh-frozen human leg pairs. The relative motion was determined under dynamic loading (extension-flexion 20° to 50°, load-level 1,200 to 2,100 N) with subsequent determination of the maximum pull-out force. In addition, the cement mantle was analyzed radiologically for possible defects, the tibia base cement adhesion, and preoperative bone mineral density (BMD). RESULTS: The BMD showed no statistically significant difference between both groups. Group A showed for all load levels significantly higher maximum relative motion compared to group S for 20° and 50° flexion. Group S improved the maximum failure load significantly compared to group A without additional cement pockets. Group S showed a significantly increased cement adhesion compared to group A. The cement penetration and cement mantle defect analysis showed no significant differences between both groups. CONCLUSION: From a biomechanical point of view, the additional cement pockets of the component have improved the fixation performance of the implant. Cite this article: Bone Joint Res 2022;11(4):229-238.

Cementing techniques for hip resurfacing arthroplasty: in vitro study of pressure and temperature.

Cementing irregularities have been associated with femoral failures of resurfacing arthroplasties in retrieval studies. We used an in vitro model to measure pressure, temperatures, and cement penetration as a function of 6 different cementing techniques. Filling the component with cement can lead to overpenetration or increase the resistance to component seating with resultant polar cement mass. Both conditions result in high and long-lasting cement pressures, cement defects, as well as peak temperatures higher than 50°C. Manual application of cement provides complete penetration of the available fixation area with the lowest cement pressures, the smallest total cement mass, and a peak temperature of 36.0°C ± 4.1°C. Application of the principles elucidated by this study may reduce the risk of cement overpenetration and incomplete seating.

The influence of cementing technique in hip resurfacing arthroplasty on the initial stability of the femoral component.

PURPOSE: In clinical and retrieval analyses, over-penetration of cement, incomplete seating of the prosthesis with a resultant polar cement mass, or both, have been associated with early femoral failures of resurfacing arthroplasties. We used human bone specimens to experimentally compare the initial stability of different cementing techniques. METHODS: Twenty-six pairs of fresh frozen femora were prepared for resurfacing using original instruments (DePuy ASR). ASR femoral resurfacing prostheses were implanted using two different cementing techniques: (1) component filling and (2) cement applicator. Real-time measurements of pressure and temperature during implantation, analyses of cement penetration and micro motions under torque application were performed. RESULTS: Applicator use reduced significantly the cement penetration depth (9.2 mm vs 5.3 mm with the applicator, p = 0.001), polar mantle (8.1 mm vs 2.6 mm, p = 0.008), cement defects (3.7 mm vs 0.1 mm, p = 0.008) and interface temperatures (40.3°C vs 33.1°C, p < 0.001 ). Initial rotational stability showed statistically significant less extreme values with the cement applicator technique (range 3.4-51.7 m°/Nm, 11.0-29.7 m°/Nm, p = 0.024). CONCLUSIONS: The cement applicator technique significantly reduces cement defects, incomplete seating, over-penetration and interface temperatures with a more consistent initial stability of the ASR femoral resurfacing prostheses.

Cement debonding behaviors of the various tibial components of the ATTUNE knee system and its predecessors: Is a cement-in-cement revision an alternative?

BACKGROUND: Aseptic loosening remains one of the most common causes of revision of the tibial component for total knee arthroplasty. A stable bond between implant and cement is essential for appropriate long-term results. The aim of our in vitro study was to investigate the maximum failure load of tibial ATTUNE prosthesis design alternatives compared with a previous design. In addition, cement-in-cement revision was considered as a potential strategy after tibial component debonding. METHODS: The experimental investigations of the maximum failure load of the implant-cement interface were performed under optimal conditions, without potential contamination. We compared the designs of the tibial components of the ATTUNE, ATTUNE S+ and P.F.C. Sigma. In addition, we investigated the cement-in-cement revision for the ATTUNE knee system replacing it with an ATTUNE S+. RESULTS: The maximum failure load showed no significant difference between P.F.C. Sigma and ATTUNE groups (P = 0.087), but there was a significant difference between the P.F.C. Sigma and the ATTUNE S+ groups (P < 0.001). The analysis also showed a significant difference (P < 0.001) between the ATTUNE and the ATTUNE S+ groups for the maximum failure load. The ATTUNE S+ cement-in-cement revision group showed a significant higher failure load (P < 0.001) compared with the P.F.C. Sigma and ATTUNE groups. No significant differences (P = 1.000) were found between the ATTUNE S+ cement-in-cement and ATTUNE S+ group. CONCLUSION: Based on these results, we found no design-specific evidence of increased debonding risk with the ATTUNE and ATTUNE S+ components compared with the P.F.C Sigma. Furthermore, the cement-in-cement revision seems to be an alternative for the revision surgery.

Pulsatile Lavage Systems with High Impact Pressure and High Flow Produce Cleaner Cancellous Bone Prior to Cementation in Cemented Arthroplasty.

In cemented joint arthroplasty, state-of-the-art cementing techniques include high-pressure pulsatile saline lavage prior to cementation. Even with its outstanding importance in cementation, there are surprisingly few studies regarding the physical parameters that define pulsatile lavage systems. To investigate the parameters of impact pressure, flow rate, frequency and the cleaning effect in cancellous bone, we established a standardized laboratory model. Standardized fat-filled carbon foam specimens representing human cancellous bone were cleaned with three different high-pressure pulsatile lavage systems. Via CT scans before and after cleaning, the cleaning effect was evaluated. All systems showed a cleaning depth of at least 3.0 mm and therefore can be generally recommended to clean cancellous bone in cemented joint arthroplasty. When comparing the three lavage systems, the study showed significant differences regarding cleaning depths and volume, with one system being superior to its peer systems. Regarding the physical parameters, high impact pressure in combination with high flow rate and longer distance to the flushed object seems to be the best combination to improve the cleaning of cancellous bone and therefore increase the chances of a deeper cement penetration that is required in cemented joint arthroplasty. In summary, this study provides the first standardized comparison of different lavage systems and thus gives initial guidance on how to optimally prepare cancellous bone for cemented joint arthroplasty.

Early tibial loosening of the cemented ATTUNE knee arthroplasty - Just a question of design?

BACKGROUND: Total knee arthroplasty is a very successful standard treatment for severe osteoarthritis. Nevertheless, the literature reports tibial debonding between implant and bone cement as well as radiolucent lines related to the tibial components of different knee systems. Regardless of cementing techniques and the influences during surgery, we examined the design of a newly developed knee system and its predecessors (Attune, Attune S+, P.F.C. Sigma, P.F.C. Sigma RP/M.B.T., all DePuy). METHODS: We investigated the dimensions of the tibial components and the fit between them and their bone bed after instrumentation in a foam material. RESULTS: Our results showed considerable differences for the used knee prostheses as well as their tibial instrumentation options with a corresponding risk for incomplete seating. CONCLUSION: The orthopedic surgeons need to be aware of these design features and the resulting increased seating resistance especially in hard and sclerotic bone. ARTICLE FOCUS: Comparison of the tibial instruments and the different design options of the Attune knee system and its predecessor knee prostheses. KEY MESSAGES: The Attune implant showed incomplete seating because of too much press fit and an uneven bone quality or sclerosis can result in tilting of the tibial component. STRENGTHS AND LIMITATIONS: This is the first study investigating the Attune knee and its predecessor in terms of implant seating and press fit. The foam material is a limitation.