Detalhe da pesquisa
1.
In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series.
Bioorg Med Chem Lett
; 18(1): 355-9, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18077160
2.
4-(2-[2-(2(R)-methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and related 2-aminoethylbenzofuran H3 receptor antagonists potently enhance cognition and attention.
J Med Chem
; 48(1): 38-55, 2005 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-15634000
3.
Effects of histamine H(3) receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup.
Behav Brain Res
; 131(1-2): 151-61, 2002 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-11844582
4.
Differential in vivo effects of H3 receptor ligands in a new mouse dipsogenia model.
Pharmacol Biochem Behav
; 72(3): 741-50, 2002 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12175472
5.
Pharmacological characterization of A-960656, a histamine H3 receptor antagonist with efficacy in animal models of osteoarthritis and neuropathic pain.
Eur J Pharmacol
; 684(1-3): 87-94, 2012 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-22504024
6.
Diaryldiamines with dual inhibition of the histamine H(3) receptor and the norepinephrine transporter and the efficacy of 4-(3-(methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in pain.
J Med Chem
; 53(21): 7869-73, 2010 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20945906
7.
Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands.
J Med Chem
; 51(20): 6571-80, 2008 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-18811133
8.
4-[6-(2-Aminoethyl)naphthalen-2-yl]benzonitriles are potent histamine H3 receptor antagonists with high CNS penetration.
Bioorg Med Chem Lett
; 17(5): 1443-6, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17169555
9.
An efficient multigram synthesis of the potent histamine H3 antagonist GT-2331 and the reassessment of the absolute configuration.
J Org Chem
; 69(1): 192-4, 2004 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-14703397