Detalhe da pesquisa
1.
Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.
Nature
; 629(8011): 443-449, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38658754
2.
Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling.
Immunity
; 52(3): 499-512.e5, 2020 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32187518
3.
BET bromodomain inhibitors regulate keratinocyte plasticity.
Nat Chem Biol
; 17(3): 280-290, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33462494
4.
An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient.
Nat Chem Biol
; 15(3): 304-313, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30692685
5.
Discovery of 1-((6-Aminopyridin-3-yl)Methyl)-3-(4-Bromophenyl)Urea as a Potent, Irreversible Myeloperoxidase Inhibitor.
J Pharmacol Exp Ther
; 367(1): 147-154, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30076263
6.
N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity.
Bioorg Med Chem Lett
; 28(12): 2153-2158, 2018 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29759726
7.
Gift from Nature: Cyclomarinâ A Kills Mycobacteria and Malaria Parasites by Distinct Modes of Action.
Chembiochem
; 16(17): 2433-6, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26472355
8.
Challenges for the Discovery of Non-Covalent WRN Helicase Inhibitors.
ChemMedChem
; 19(8): e202300613, 2024 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38334957
9.
Ligandability Assessment of IL-1ß by Integrated Hit Identification Approaches.
J Med Chem
; 67(10): 8141-8160, 2024 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38728572
10.
Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction.
ACS Chem Biol
; 18(1): 34-40, 2023 01 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36594833
11.
Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1ß.
Nat Commun
; 14(1): 5497, 2023 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37679328
12.
Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist.
ACS Med Chem Lett
; 13(4): 658-664, 2022 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35450354
13.
Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing.
J Med Chem
; 63(23): 14576-14593, 2020 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33252239
14.
Evolution of Novartis' Small Molecule Screening Deck Design.
J Med Chem
; 63(23): 14425-14447, 2020 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33140646
15.
Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay.
J Med Chem
; 63(15): 8276-8295, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32786235
16.
Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4.
J Med Chem
; 63(21): 12542-12573, 2020 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32930584
17.
FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer.
Mol Cancer Ther
; 18(12): 2194-2206, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31409633
18.
Approaches to selective fibroblast growth factor receptor 4 inhibition through targeting the ATP-pocket middle-hinge region.
Medchemcomm
; 8(8): 1604-1613, 2017 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108871
19.
Readout technologies for highly miniaturized kinase assays applicable to high-throughput screening in a 1536-well format.
J Biomol Screen
; 11(6): 617-33, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16760365
20.
Purification, crystallization and preliminary crystallographic analysis of Arabidopsis thaliana imidazoleglycerol-phosphate dehydratase.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 61(Pt 8): 776-8, 2005 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16511155