Detalhe da pesquisa
1.
Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles.
J Virol
; 97(10): e0072223, 2023 10 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37754761
2.
Class A capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation.
Hepatology
; 78(4): 1252-1265, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37102495
3.
Old vaccines for new infections: Exploiting innate immunity to control COVID-19 and prevent future pandemics.
Proc Natl Acad Sci U S A
; 118(21)2021 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34006644
4.
Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models.
Int J Mol Sci
; 24(22)2023 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38003463
5.
ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model.
Biochem Biophys Res Commun
; 555: 134-139, 2021 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33813272
6.
Respiratory syncytial virus-A dynamics and the effects of lumicitabine, a nucleoside viral replication inhibitor, in experimentally infected humans.
J Antimicrob Chemother
; 74(2): 442-452, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30376079
7.
Short-Duration AL-335, Odalasvir, With or Without Simeprevir, in Patients With HCV GT1 or 3 Infection Without Cirrhosis.
Hepatology
; 68(6): 2145-2157, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30070722
8.
Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study.
N Engl J Med
; 373(21): 2048-58, 2015 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26580997
9.
Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate.
PLoS Pathog
; 11(6): e1004995, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-26098424
10.
An in vivo duck hepatitis B virus model recapitulates key aspects of nucleic acid polymer treatment outcomes in chronic hepatitis B patients.
Antiviral Res
; 224: 105835, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38401714
11.
The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir.
mBio
; 14(1): e0281522, 2023 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36625640
12.
Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir.
Antimicrob Agents Chemother
; 56(2): 830-7, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22143520
13.
Synthesis and enzymatic deprotection of fully protected 2'-5' oligoadenylates (2-5A): towards a prodrug strategy for short 2-5A.
Chem Biodivers
; 9(4): 669-88, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22492487
14.
Mechanism of action of hepatitis B virus S antigen transport-inhibiting oligonucleotide polymer, STOPS, molecules.
Mol Ther Nucleic Acids
; 27: 335-348, 2022 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35024245
15.
One vaccine to counter many diseases? Modeling the economics of oral polio vaccine against child mortality and COVID-19.
Front Public Health
; 10: 967920, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36276367
16.
Treatment of chronic hepatitis C patients with the NS3/4A protease inhibitor danoprevir (ITMN-191/RG7227) leads to robust reductions in viral RNA: a phase 1b multiple ascending dose study.
J Hepatol
; 54(6): 1130-6, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21145848
17.
Evaluation of current treatment recommendations for chronic hepatitis B: a 2011 update.
J Gastroenterol Hepatol
; 26(5): 829-35, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21214888
18.
Synthesis and enzymatic deprotection of biodegradably protected dinucleoside-2',5'-monophosphates: 3-(acetyloxy)-2,2-bis(ethoxycarbonyl)propyl phosphoesters of 3'-O-(acyloxymethyl)adenylyl-2',5'-adenosines.
Chem Biodivers
; 8(2): 266-86, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21337500
19.
Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development.
Antiviral Res
; 187: 105020, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33515606
20.
Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry.
Antiviral Res
; 182: 104924, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32896566