Detalhe da pesquisa
1.
Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose.
Bioorg Med Chem Lett
; 22(21): 6621-7, 2012 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23010266
2.
Inhibitors of human histone deacetylase: synthesis and enzyme assay of hydroxamates with piperazine linker.
Arch Pharm (Weinheim)
; 343(3): 167-72, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20217840
3.
Retention of misfolded mutant transthyretin by the chaperone BiP/GRP78 mitigates amyloidogenesis.
J Mol Biol
; 356(2): 469-82, 2006 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-16376939
4.
Photoreactive "nanorulers" detect a novel conformation of full length HDAC3-SMRT complex in solution.
ACS Chem Biol
; 8(11): 2538-49, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24010878
5.
Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes.
J Med Chem
; 54(13): 4350-64, 2011 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21548582
6.
Use of molecular modeling, docking, and 3D-QSAR studies for the determination of the binding mode of benzofuran-3-yl-(indol-3-yl)maleimides as GSK-3beta inhibitors.
J Mol Model
; 15(12): 1463-79, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19440740
7.
Binding ensemble profiling with photoaffinity labeling (BEProFL) approach: mapping the binding poses of HDAC8 inhibitors.
J Med Chem
; 52(22): 7003-13, 2009 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-19886628
8.
From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells.
J Med Chem
; 52(7): 1853-63, 2009 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-19338355
9.
Catalytically active monomer of glutathione S-transferase pi and key residues involved in the electrostatic interaction between subunits.
J Biol Chem
; 283(47): 32880-8, 2008 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-18796433
10.
Structure-based design leads to the identification of lithium mimetics that block mania-like effects in rodents. possible new GSK-3beta therapies for bipolar disorders.
J Am Chem Soc
; 129(26): 8328-32, 2007 Jul 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-17552518
11.
Highly potent and specific GSK-3beta inhibitors that block tau phosphorylation and decrease alpha-synuclein protein expression in a cellular model of Parkinson's disease.
ChemMedChem
; 1(2): 256-66, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16892358
12.
BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4.
Biochem Biophys Res Commun
; 338(3): 1467-77, 2005 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-16271702
13.
The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity.
J Biol Chem
; 279(12): 11432-43, 2004 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-14668352
14.
Inhibition of cellular enzymes by equine catechol estrogens in human breast cancer cells: specificity for glutathione S-transferase P1-1.
Chem Res Toxicol
; 15(7): 935-42, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12119004