Detalhe da pesquisa
1.
Phe19 modification of HDM2-p53 PPI inhibitors to alleviate CYP3A4 metabolism/mechanism-based inhibition liability.
Bioorg Med Chem Lett
; 61: 128625, 2022 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35158044
2.
Concise syntheses and HCV NS5B polymerase inhibition of (2'R)-3 and (2'S)-2'-ethynyluridine-10 and related nucleosides.
Bioorg Med Chem Lett
; 27(23): 5349-5352, 2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29056248
3.
Structure-activity relationship study of 4-substituted piperidines at Leu26 moiety of novel p53-hDM2 inhibitors.
Bioorg Med Chem Lett
; 26(11): 2735-8, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27080185
4.
Core modification of substituted piperidines as novel inhibitors of HDM2-p53 protein-protein interaction.
Bioorg Med Chem Lett
; 24(8): 1983-6, 2014 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24656661
5.
Diminishing GSH-Adduct Formation of Tricyclic Diazepine-based Mutant IDH1 Inhibitors.
ACS Med Chem Lett
; 13(4): 734-741, 2022 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35450359
6.
Discovery of MK-4688: an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction.
J Med Chem
; 64(21): 16213-16241, 2021 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34714078
7.
Towards the second generation of Boceprevir: Dithianes as an alternative P2 substituent for 2,2-dimethyl cycloproyl proline in HCV NS3 protease inhibitors.
Bioorg Med Chem Lett
; 20(5): 1689-92, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20149655
8.
P4 capped amides and lactams as HCV NS3 protease inhibitors with improved potency and DMPK profile.
Bioorg Med Chem Lett
; 20(2): 567-70, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20004570
9.
The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor.
Bioorg Med Chem Lett
; 20(8): 2617-21, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20303756
10.
Discovery of potent sulfonamide P4-capped ketoamide second generation inhibitors of hepatitis C virus NS3 serine protease with favorable pharmacokinetic profiles in preclinical species.
Bioorg Med Chem
; 18(5): 1854-65, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20149666
11.
Discovery of novel P3 sulfonamide-capped inhibitors of HCV NS3 protease. Inhibitors with improved cellular potencies.
Bioorg Med Chem
; 17(13): 4486-95, 2009 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19481946
12.
Characterization of resistance mutations against HCV ketoamide protease inhibitors.
Antiviral Res
; 77(3): 177-85, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18201776
13.
Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.
J Med Chem
; 50(10): 2310-8, 2007 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-17444623
14.
Discovery of SCH446211 (SCH6): a new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication.
J Med Chem
; 49(9): 2750-7, 2006 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-16640336
15.
Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor: a potential therapeutic agent for the treatment of hepatitis C infection.
J Med Chem
; 49(20): 6074-86, 2006 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17004721
16.
Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors.
ACS Med Chem Lett
; 7(3): 324-9, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26985323
17.
2'-Modified Guanosine Analogs for the Treatment of HCV.
Nucleosides Nucleotides Nucleic Acids
; 35(6): 277-94, 2016 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27104963
18.
Study of a Radical Cyclizations Cascade Leading to Bicyclo[3.1.1]heptanes.
J Org Chem
; 64(3): 819-825, 1999 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-11674152
19.
5-Endo-Trig Radical Cyclizations of Bromomethyldimethylsilyl Diisopropylpropargylic Ethers. A Highly Diastereoselective Access to Functionalized Cyclopentanes.
J Org Chem
; 64(13): 4920-4925, 1999 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-11674571
20.
Studies of Acyl Nitrene Insertions. A Stereocontrolled Route toward Lankacidin Antibiotics.
J Org Chem
; 64(3): 736-746, 1999 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-11674141