Detalhe da pesquisa
1.
Control of backbone chemistry and chirality boost oligonucleotide splice switching activity.
Nucleic Acids Res
; 50(10): 5443-5466, 2022 06 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35061895
2.
Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res
; 46(16): 8090-8104, 2018 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30107495
3.
Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase.
Biochemistry
; 56(13): 1865-1878, 2017 04 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28225601
4.
Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase.
Biochemistry
; 55(21): 2992-3006, 2016 05 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-27136302
5.
Rational Modulation of the Induced-Fit Conformational Change for Slow-Onset Inhibition in Mycobacterium tuberculosis InhA.
Biochemistry
; 54(30): 4683-91, 2015 Aug 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26147157
6.
Diacyltransferase Activity and Chain Length Specificity of Mycobacterium tuberculosis PapA5 in the Synthesis of Alkyl ß-Diol Lipids.
Biochemistry
; 54(35): 5457-68, 2015 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26271001
7.
An ordered water channel in Staphylococcus aureus FabI: unraveling the mechanism of substrate recognition and reduction.
Biochemistry
; 54(10): 1943-55, 2015 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25706582
8.
Rational design of broad spectrum antibacterial activity based on a clinically relevant enoyl-acyl carrier protein (ACP) reductase inhibitor.
J Biol Chem
; 289(23): 15987-6005, 2014 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-24739388
9.
Structural basis for the recognition of mycolic acid precursors by KasA, a condensing enzyme and drug target from Mycobacterium tuberculosis.
J Biol Chem
; 288(47): 34190-34204, 2013 Nov 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-24108128
10.
Thiolactomycin-based ß-ketoacyl-AcpM synthase A (KasA) inhibitors: fragment-based inhibitor discovery using transient one-dimensional nuclear overhauser effect NMR spectroscopy.
J Biol Chem
; 288(9): 6045-52, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23306195
11.
Substituted diphenyl ethers as a novel chemotherapeutic platform against Burkholderia pseudomallei.
Antimicrob Agents Chemother
; 58(3): 1646-51, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24379198
12.
The Francisella tularensis FabI enoyl-acyl carrier protein reductase gene is essential to bacterial viability and is expressed during infection.
J Bacteriol
; 195(2): 351-8, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23144254
13.
Rational optimization of drug-target residence time: insights from inhibitor binding to the Staphylococcus aureus FabI enzyme-product complex.
Biochemistry
; 52(24): 4217-28, 2013 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-23697754
14.
Innate-like control of human iNKT cell autoreactivity via the hypervariable CDR3beta loop.
PLoS Biol
; 8(6): e1000402, 2010 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-20585371
15.
Slow onset inhibition of bacterial beta-ketoacyl-acyl carrier protein synthases by thiolactomycin.
J Biol Chem
; 285(9): 6161-9, 2010 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20018879
16.
Formulation studies of InhA inhibitors and combination therapy to improve efficacy against Mycobacterium tuberculosis.
Tuberculosis (Edinb)
; 101: 8-14, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27865404
17.
Thiolactomycin-Based Inhibitors of Bacterial ß-Ketoacyl-ACP Synthases with in Vivo Activity.
J Med Chem
; 59(11): 5377-90, 2016 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27187871
18.
A structural and energetic model for the slow-onset inhibition of the Mycobacterium tuberculosis enoyl-ACP reductase InhA.
ACS Chem Biol
; 9(4): 986-93, 2014 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24527857
19.
Time-dependent diaryl ether inhibitors of InhA: structure-activity relationship studies of enzyme inhibition, antibacterial activity, and in vivo efficacy.
ChemMedChem
; 9(4): 776-91, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24616444