Detalhe da pesquisa
1.
The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation.
Mol Oncol
; 2024 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38533616
2.
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells.
Nat Metab
; 5(4): 642-659, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37012496
3.
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Nat Cancer
; 3(2): 156-172, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35228749
4.
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination.
Nat Commun
; 9(1): 3872, 2018 09 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30250201
5.
Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor.
Cancer Res
; 77(4): 937-948, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27899380