Detalhe da pesquisa
1.
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins.
Nat Chem Biol
; 19(10): 1246-1255, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37592157
2.
Metabolism of a hybrid algal galactan by members of the human gut microbiome.
Nat Chem Biol
; 18(5): 501-510, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35289327
3.
Architecturally complex O-glycopeptidases are customized for mucin recognition and hydrolysis.
Proc Natl Acad Sci U S A
; 118(10)2021 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33658366
4.
A previously uncharacterized O-glycopeptidase from Akkermansia muciniphila requires the Tn-antigen for cleavage of the peptide bond.
J Biol Chem
; 298(10): 102439, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36049519
5.
Molecular Characterization of Clinical Rel Mutations and Consequences for Resistance Expression and Fitness in Staphylococcus aureus.
Antimicrob Agents Chemother
; 66(12): e0093822, 2022 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36346240
6.
Pharmacological Chaperones for GCase that Switch Conformation with pH Enhance Enzyme Levels in Gaucher Animal Models.
Angew Chem Int Ed Engl
; 61(38): e202207974, 2022 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35864061
7.
The structure of a family 110 glycoside hydrolase provides insight into the hydrolysis of α-1,3-galactosidic linkages in λ-carrageenan and blood group antigens.
J Biol Chem
; 295(52): 18426-18435, 2020 12 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33127644
8.
Structural evidence for a proline-specific glycopeptide recognition domain in an O-glycopeptidase.
Glycobiology
; 31(4): 385-390, 2021 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33030205
9.
The glycoconjugate-degrading enzymes of Clostridium perfringens: Tailored catalysts for breaching the intestinal mucus barrier.
Glycobiology
; 31(6): 681-690, 2021 06 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32472136
10.
Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism.
Nature
; 517(7533): 165-169, 2015 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25567280
11.
Molecular analysis of an enigmatic Streptococcus pneumoniae virulence factor: The raffinose-family oligosaccharide utilization system.
J Biol Chem
; 294(46): 17197-17208, 2019 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31591266
12.
Two complementary α-fucosidases from Streptococcus pneumoniae promote complete degradation of host-derived carbohydrate antigens.
J Biol Chem
; 294(34): 12670-12682, 2019 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31266803
13.
Clinical Mutations That Partially Activate the Stringent Response Confer Multidrug Tolerance in Staphylococcus aureus.
Antimicrob Agents Chemother
; 64(3)2020 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31871080
14.
Recognition of protein-linked glycans as a determinant of peptidase activity.
Proc Natl Acad Sci U S A
; 114(5): E679-E688, 2017 01 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-28096352
15.
Endo-fucoidan hydrolases from glycoside hydrolase family 107 (GH107) display structural and mechanistic similarities to α-l-fucosidases from GH29.
J Biol Chem
; 293(47): 18296-18308, 2018 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30282808
16.
Structural and functional analysis of four family 84 glycoside hydrolases from the opportunistic pathogen Clostridium perfringens.
Glycobiology
; 30(1): 49-57, 2019 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31701135
17.
Molecular Characterization of N-glycan Degradation and Transport in Streptococcus pneumoniae and Its Contribution to Virulence.
PLoS Pathog
; 13(1): e1006090, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28056108
18.
Biochemical Reconstruction of a Metabolic Pathway from a Marine Bacterium Reveals Its Mechanism of Pectin Depolymerization.
Appl Environ Microbiol
; 85(1)2019 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30341080
19.
KdgF, the missing link in the microbial metabolism of uronate sugars from pectin and alginate.
Proc Natl Acad Sci U S A
; 113(22): 6188-93, 2016 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-27185956
20.
Properties of a family 56 carbohydrate-binding module and its role in the recognition and hydrolysis of ß-1,3-glucan.
J Biol Chem
; 292(41): 16955-16968, 2017 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28827308