Effect of regenerative injection therapy on function and pain in patients with knee osteoarthritis: a randomized crossover study.

OBJECTIVE: We assessed the effectiveness of regenerative injection therapy (RIT) to relieve pain and restore function in patients with knee osteoarthritis. DESIGN: Crossover study where participants were randomly assigned to receive exercise therapy for 32 weeks in combination with RIT on weeks 0, 4, 8, and 12 or RIT on weeks 20, 24, 28, and 32. PATIENTS: Thirty-six patients with chronic knee osteoarthritis. INTERVENTIONS: RIT, which is made up of injections of 1 cc of 15% dextrose 0.6% lidocaine in the collateral ligaments and a 5 cc injection of 20% dextrose 0.5% lidocaine inside the knee joint. OUTCOME MEASURES: The primary outcome was the Western Ontario and McMaster Universities Osteoarthritis Index of severity of osteoarthrosis symptoms (WOMAC) score (range: 0-96). RESULTS: Following 16 weeks of follow-up, the participants assigned to RIT presented a significant reduction of their osteoarthritis symptoms (mean ± standard deviation: -21.8 ± 12.5, P < 0.001). WOMAC scores in this group did not change further during the last 16 weeks of follow-up, when the participants received exercise therapy only (-1.2 ± 10.7, P = 0.65). WOMAC scores in the first 16 weeks did not change significantly among the participants receiving exercise therapy only during this period (-6.1±13.9, P=0.11). There was a significant decrease in this groups' WOMAC scores during the last 16 weeks when the participants received RIT (-9.3±11.4, P=0.006). After 36 weeks, WOMAC scores improved in both groups by 47.3% and 36.2%. The improvement attributable to RIT alone corresponds to a 11.9-point (or 29.5%) decrease in WOMAC scores. CONCLUSIONS: The use of RIT is associated with a marked reduction in symptoms, which was sustained for over 24 weeks.

Improving the recruitment and retention of doctors by training medical students locally.

CONTEXT: The global shortage of doctors is of concern. This is particularly true in French-speaking regions of New Brunswick, Canada, where there is no medical school. Since 1981, francophone medical students from New Brunswick have been able to undertake part of their training in their province through an agreement with medical schools in another province. We studied the effects of frequency and length of exposure to the province of origin during medical training on the likelihood that a doctor will ever or currently practise medicine in that province. METHODS: A questionnaire was sent to 390 francophone doctors from New Brunswick to collect information on history of medical training and practice. Multivariate logistic regressions were used to identify whether exposure to New Brunswick during medical training at the undergraduate and postgraduate levels affects the likelihood of ever or currently practising in the province. RESULTS: A total of 263 doctors participated. Among family doctors, those with exposure to their province of origin in 1, 2, 3 or 4 years of undergraduate training were 2.5 (95% confidence interval [CI] 0.8-7.4), 2.5 (95% CI 0.7-8.6), 9.3 (95% CI 1.5-56.9) and 9.3 (95% CI 1.4-60.1) times more likely, respectively, to currently practise in New Brunswick than doctors who had experienced no exposure to the province during undergraduate training. Among specialty doctors, exposure to New Brunswick during undergraduate training had no effect on location of practice. Family and specialty doctors who had been exposed to New Brunswick during postgraduate residency were 5.9 (95% CI 2.3-14.9) and 3.2 (95% CI 0.9-11.6) times more likely, respectively, to practise in the province than doctors without postgraduate exposure. CONCLUSIONS: Greater exposure to New Brunswick during medical training is associated with significantly better odds that doctors will be recruited to and retained in the province. Some effects are perceived for exposure during both undergraduate (most importantly in the final years) and postgraduate programmes.

Recruiting doctors from and for underserved groups: Does New Brunswick's initiative to recruit doctors for its linguistic minority help rural communities?

OBJECTIVES: Within health care, there are underserved groups. New Brunswick's French-speaking minority, which also mostly lives in rural communities, is one such group. A physician shortage potentially prevents this population from accessing health promotion and clinical prevention services. This study analyzes whether New Brunswick Francophone doctors with rural backgrounds are more likely than doctors from urban regions to set up practice in rural communities of the province. METHODS: A questionnaire was sent to 390 New Brunswick Francophone physicians admitted in medicine between 1973 and 2000. It collected information on geographic origin and history of medical practice. Multivariate logistic regressions were used to identify whether a rural background is associated with the likelihood of ever and currently practicing in rural communities. We used the General Practice Rurality Index-simplified to quantify the rurality level of communities. RESULTS: In total, 264 (67%) physicians participated. A rural background was positively associated with the establishment of a first medical practice in a rural community. This relationship was only significant among family physicians. There was no statistically significant relationship between rurality of community of origin and rurality of current community of practice among either family or specialty physicians. CONCLUSION: Although Francophone doctors with a rural background were more likely than their urban counterparts to set up their first practice in a rural community, this effect was not sustained. This raises questions as to why they leave rural communities and highlights the importance of measures to retain doctors as a way to promote public health for underserved rural groups.