Detalhe da pesquisa
1.
Comparison of Proteomic Quantification Approaches for Hepatic Drug Transporters: Multiplexed Global Quantitation Correlates with Targeted Proteomic Quantitation.
Drug Metab Dispos
; 46(5): 692-696, 2018 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-29439128
2.
Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif.
Bioorg Med Chem Lett
; 23(16): 4571-8, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23831135
3.
Modulation of glucokinase by glucose, small-molecule activator and glucokinase regulatory protein: steady-state kinetic and cell-based analysis.
Biochem J
; 441(3): 881-7, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22044397
4.
Novel and selective spiroindoline-based inhibitors of Sky kinase.
Bioorg Med Chem Lett
; 22(1): 190-3, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22119469
5.
The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of type 2 diabetes mellitus.
Bioorg Med Chem Lett
; 22(23): 7100-5, 2012 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23089526
6.
Pyridones as glucokinase activators: identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle.
Bioorg Med Chem Lett
; 19(12): 3247-52, 2009 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19435665
7.
Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.
Nat Commun
; 6: 7645, 2015 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26134520
8.
Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.
J Med Chem
; 55(3): 1318-33, 2012 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-22196621