Detalhe da pesquisa
1.
Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils.
Proc Natl Acad Sci U S A
; 120(41): e2300258120, 2023 10 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37801475
2.
Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation.
J Biol Chem
; 300(2): 105531, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38072051
3.
Intravitreal aflibercept 8 mg in diabetic macular oedema (PHOTON): 48-week results from a randomised, double-masked, non-inferiority, phase 2/3 trial.
Lancet
; 403(10432): 1153-1163, 2024 Mar 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38461843
4.
Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation.
Proc Natl Acad Sci U S A
; 119(15): e2119952119, 2022 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35377792
5.
Pegcetacoplan for the treatment of geographic atrophy secondary to age-related macular degeneration (OAKS and DERBY): two multicentre, randomised, double-masked, sham-controlled, phase 3 trials.
Lancet
; 402(10411): 1434-1448, 2023 10 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37865470
6.
LIGHTSITE III: 13-Month Efficacy and Safety Evaluation of Multiwavelength Photobiomodulation in Nonexudative (Dry) Age-Related Macular Degeneration Using the Lumithera Valeda Light Delivery System.
Retina
; 44(3): 487-497, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37972955
7.
SUPRACHOROIDAL SPACE INJECTION TECHNIQUE: Expert Panel Guidance.
Retina
; 44(6): 939-949, 2024 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38451179
8.
Intrinsic electronic conductivity of individual atomically resolved amyloid crystals reveals micrometer-long hole hopping via tyrosines.
Proc Natl Acad Sci U S A
; 118(2)2021 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33372136
9.
Micro-electron diffraction structure of the aggregation-driving N terminus of Drosophila neuronal protein Orb2A reveals amyloid-like ß-sheets.
J Biol Chem
; 298(10): 102396, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35988647
10.
A Randomized Controlled Trial of OPT-302, a VEGF-C/D Inhibitor for Neovascular Age-Related Macular Degeneration.
Ophthalmology
; 130(6): 588-597, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36754174
11.
PHASE 2 RANDOMIZED STUDY (ORION-1) OF A NOVEL, BIODEGRADABLE DEXAMETHASONE IMPLANT (AR-1105) FOR THE TREATMENT OF MACULAR EDEMA DUE TO CENTRAL OR BRANCH RETINAL VEIN OCCLUSION.
Retina
; 43(1): 25-33, 2023 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36542081
12.
The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure.
Proc Natl Acad Sci U S A
; 117(7): 3592-3602, 2020 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32015135
13.
INTRAVITREAL NESVACUMAB (ANTIANGIOPOIETIN 2) PLUS AFLIBERCEPT IN DIABETIC MACULAR EDEMA: Phase 2 RUBY Randomized Trial.
Retina
; 42(6): 1111-1120, 2022 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35234673
14.
PHASE 2 STUDY OF THE SAFETY AND EFFICACY OF BRIMONIDINE DRUG DELIVERY SYSTEM (BRIMO DDS) GENERATION 1 IN PATIENTS WITH GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION.
Retina
; 41(1): 144-155, 2021 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32134802
15.
The Use of Neuroprotective Agents in Treating Geographic Atrophy.
Ophthalmic Res
; 64(6): 888-902, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34153966
16.
Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples.
J Biol Chem
; 294(44): 16451-16464, 2019 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31537646
17.
Complement C3 Inhibitor Pegcetacoplan for Geographic Atrophy Secondary to Age-Related Macular Degeneration: A Randomized Phase 2 Trial.
Ophthalmology
; 127(2): 186-195, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31474439
18.
Consensus Nomenclature for Reporting Neovascular Age-Related Macular Degeneration Data: Consensus on Neovascular Age-Related Macular Degeneration Nomenclature Study Group.
Ophthalmology
; 127(5): 616-636, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31864668
19.
SUPPLEMENTAL SCLERAL BUCKLE IN THE ERA OF SMALL INCISION VITRECTOMY AND WIDE-ANGLE VIEWING SYSTEMS.
Retina
; 40(10): 1894-1899, 2020 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-31834132
20.
The Developing Regorafenib Eye drops for neovascular Age-related Macular degeneration (DREAM) study: an open-label phase II trial.
Br J Clin Pharmacol
; 85(2): 347-355, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30341774