Characteristics and Outcomes for Recipients of NVX-CoV2373: A Real-World Retrospective Study in Germany.

Real-world evidence supports SARS-CoV-2 vaccination strategies during the COVID-19 pandemic. This real-world retrospective study utilized the German Disease Analyzer database to characterize recipients of NVX-CoV2373 and explore vaccination outcomes. Recipients (≥12 years) of NVX-CoV2373 as a primary series or booster in Germany were vaccinated between March and December 2022. Outcomes included demographics and clinical characteristics of recipients, tolerability/reactogenicity-related events within 7 and 14 days post-vaccination, and protection from COVID-19. Overall, there were 597 recipients (mean age ~60 years) of NVX-CoV2373; 81% were vaccinated by a general practitioner, and 68% had a Standing Committee on Vaccination (STIKO) high-risk factor. The most common baseline comorbidities were chronic neurological (36%) and chronic intestinal (21%) diseases. Among recipients with metabolic disease (~11%), 65% had diabetes. Tolerability/reactogenicity-related symptoms were recorded in ~1% of recipients. There were no sick-leave notes associated with NVX-CoV2373. After 10 months (median, 7 months) of follow-up, 95% (95% CI, 93-95) of recipients were estimated to be protected from COVID-19. Outcomes were similar across the primary series, booster, and STIKO populations. Tolerability and COVID-19 protection support the use of NVX-CoV2373 as a primary/booster vaccination for all authorized populations, including high-risk.

Perceptual-motor recalibration is intact in older adults.

From an ecological perspective, perceptual-motor recalibration should be a robust and adaptable process, but there are suggestions that older adults may recalibrate slower. Therefore, this study investigated the age-related temporal effects in perceptual-motor recalibration after motor disturbances. In three experiments, we disturbed young and older adults' perception-action by fitting weights around their ankles and asking them to climb stairs or cross obstacles repeatedly. In Experiment 1, participants (n = 26) climbed stairs with different ankle weights. An innovative methodology was applied, identifying the timeline of recalibration as the point where a stable movement pattern emerged. Experiment 1 showed that older adults recalibrated slower than young adults in lighter (but not heavier) weight conditions. In Experiment 2, participants (n = 24) crossed obstacles with different ankle weights. Results showed that older adults recalibrated faster than young adults. Finally, in Experiment 3, participants (n = 24) crossed obstacles of unpredictable and varying heights with heavy ankle weights. Again, results showed that older adults recalibrated faster than young adults. Taken together these results show that although older adults had reduced muscle strength and flexibility, they recalibrated quickly, especially when the task was more challenging.

Recalibration in functional perceptual-motor tasks: A systematic review.

Skilled actions are the result of a perceptual-motor system being well-calibrated to the appropriate information variables. Changes to the perceptual or motor system initiates recalibration, which is the rescaling of the perceptual-motor system to informational variables. For example, a professional baseball player may need to rescale their throws due to fatigue. The aim of this systematic review is to analyse how recalibration can and has been measured and also to evaluate the literature on recalibration. Five databases were systematically screened to identify literature that reported experiments where a disturbance was applied to the perceptual-motor system in functional perceptual-motor tasks. Each of the 91 experiments reported the immediate effects of a disturbance and/or the effects of removing that disturbance after recalibration. The results showed that experiments applied disturbances to either perception or action, and used either direct or indirect measures of recalibration. In contrast with previous conclusions, active exploration was only sufficient for fast recalibration when the relevant information source was available. Further research into recalibration mechanisms should include the study of information sources as well as skill expertise.