Detalhe da pesquisa
1.
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
Cell
; 179(2): 417-431.e19, 2019 Oct 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31585081
2.
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
Cell
; 180(2): 406, 2020 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31978350
3.
Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability.
Bioorg Med Chem Lett
; 26(2): 575-579, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26675441
4.
Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834.
Bioorg Med Chem Lett
; 25(6): 1333-7, 2015 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25701252
5.
Mini-PBPK-Based Population Model and Covariate Analysis to Assess the Complex Pharmacokinetics and Pharmacodynamics of RO7449135, an Anti-KLK5/KLK7 Bispecific Antibody in Cynomolgus Monkeys.
AAPS J
; 25(4): 64, 2023 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37353723
6.
Dose-dependent inactivation of airway tryptase with a novel dissociating anti-tryptase antibody (MTPS9579A) in healthy participants: A randomized trial.
Clin Transl Sci
; 15(2): 451-463, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34581002
7.
Development of a specific immunoassay to selectively measure active tryptase in airway samples.
Bioanalysis
; 12(19): 1377-1388, 2020 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-32975431
8.
IL-17A is associated with the breakdown of the blood-brain barrier in relapsing-remitting multiple sclerosis.
J Neuroimmunol
; 332: 147-154, 2019 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31034962
9.
Safety, Pharmacokinetics, and Pharmacodynamics in Healthy Volunteers Treated With GDC-0853, a Selective Reversible Bruton's Tyrosine Kinase Inhibitor.
Clin Pharmacol Ther
; 103(6): 1020-1028, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29484638
10.
Development of a multi-matrix LC-MS/MS method for urea quantitation and its application in human respiratory disease studies.
J Pharm Biomed Anal
; 133: 96-104, 2017 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-27825650
11.
Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties.
ACS Med Chem Lett
; 8(6): 608-613, 2017 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28626519
12.
Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFNα-driven lupus nephritis.
JCI Insight
; 2(7): e90111, 2017 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28405610
13.
Preclinical Safety Profile of a Depleting Antibody against CRTh2 for Asthma: Well Tolerated Despite Unexpected CRTh2 Expression on Vascular Pericytes in the Central Nervous System and Gastric Mucosa.
Toxicol Sci
; 152(1): 72-84, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27103662
14.
The minimal essential core of a cysteine-based protein-tyrosine phosphatase revealed by a novel 16-kDa VH1-like phosphatase, VHZ.
J Biol Chem
; 279(34): 35768-74, 2004 Aug 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-15201283
15.
The oxidative mechanism of action of ortho-quinone inhibitors of protein-tyrosine phosphatase alpha is mediated by hydrogen peroxide.
Arch Biochem Biophys
; 429(1): 30-41, 2004 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15288807
16.
VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX.
J Biol Chem
; 279(31): 32586-91, 2004 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15138252