Detalhe da pesquisa
1.
Pharmacokinetic/Pharmacodynamic Correlation Analysis of Amantadine for Levodopa-Induced Dyskinesia.
J Pharmacol Exp Ther
; 367(2): 373-381, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30087157
2.
Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors.
Bioorg Med Chem Lett
; 23(7): 1974-7, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23453068
3.
Amino-caprolactam γ-secretase inhibitors showing potential for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 21(12): 3715-20, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21571529
4.
Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor.
Bioorg Med Chem Lett
; 21(6): 1838-43, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21316234
5.
Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors.
Bioorg Med Chem Lett
; 21(19): 5791-4, 2011 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21885276
6.
Discovery of sulfonamide-pyrazole gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 20(7): 2148-50, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20206516
7.
Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors (Part II).
Bioorg Med Chem Lett
; 20(12): 3502-6, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20529683
8.
Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model.
Bioorg Med Chem Lett
; 20(21): 6231-6, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20833041
9.
Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 19(17): 4920-3, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19660943
10.
Leucine-rich repeat kinase 2 (LRRK2)-deficient rats exhibit renal tubule injury and perturbations in metabolic and immunological homeostasis.
PLoS One
; 8(6): e66164, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23799078
11.
Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-ß over Notch.
J Med Chem
; 56(13): 5261-74, 2013 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23713656
12.
Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.
Alzheimers Res Ther
; 2(6): 36, 2010 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-21190552
13.
Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system.
J Biol Chem
; 284(5): 2598-2602, 2009 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-19004816
14.
Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice.
J Biol Chem
; 282(36): 26326-34, 2007 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-17616527