Detalhe da pesquisa
1.
Design, synthesis, docking, and biochemical characterization of non-nucleoside SARS-CoV-2 RdRp inhibitors.
Bioorg Med Chem
; 80: 117179, 2023 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36716583
2.
Phenyl-γ-valerolactones and phenylvaleric acids, the main colonic metabolites of flavan-3-ols: synthesis, analysis, bioavailability, and bioactivity.
Nat Prod Rep
; 36(5): 714-752, 2019 05 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30468210
3.
Exploiting the Distal Reactivity of Indolyl Methylenemalononitriles: An Asymmetric Organocatalyzed [4+2] Cycloaddition with Enals Enables the Assembly of Elusive Dihydrocarbazoles.
Chemistry
; 22(36): 12637-40, 2016 Aug 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27348410
4.
Pushing the boundaries of vinylogous reactivity: catalytic enantioselective mukaiyama aldol reactions of highly unsaturated 2-silyloxyindoles.
Chemistry
; 21(17): 6433-42, 2015 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25735832
5.
Organocatalytic, Asymmetric Eliminative [4+2] Cycloaddition of Allylidene Malononitriles with Enals: Rapid Entry to Cyclohexadiene-Embedding Linear and Angular Polycycles.
Angew Chem Int Ed Engl
; 54(25): 7386-90, 2015 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25950770
6.
Tumor growth-arrest effect of tetrahydroquinazoline-derivative human topoisomerase II-alpha inhibitor in HPV-negative head and neck squamous cell carcinoma.
Sci Rep
; 14(1): 9150, 2024 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38644364
7.
Targeting the conserved active site of splicing machines with specific and selective small molecule modulators.
Nat Commun
; 15(1): 4980, 2024 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38898052
8.
Discovery of CDC42 Inhibitors with a Favorable Pharmacokinetic Profile and Anticancer In Vivo Efficacy.
J Med Chem
; 2024 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38866385
9.
Computer-aided identification, synthesis, and biological evaluation of DNA polymerase η inhibitors for the treatment of cancer.
Eur J Med Chem
; 248: 115044, 2023 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36621139
10.
Design, Synthesis, In Vitro and In Vivo Characterization of CDC42 GTPase Interaction Inhibitors for the Treatment of Cancer.
J Med Chem
; 66(8): 5981-6001, 2023 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37026468
11.
Quercetin and luteolin are single-digit micromolar inhibitors of the SARS-CoV-2 RNA-dependent RNA polymerase.
Sci Rep
; 12(1): 10571, 2022 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35732785
12.
Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer.
Cell Rep
; 39(1): 110641, 2022 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35385746
13.
Design, Synthesis, Dynamic Docking, Biochemical Characterization, and in Vivo Pharmacokinetics Studies of Novel Topoisomerase II Poisons with Promising Antiproliferative Activity.
J Med Chem
; 63(7): 3508-3521, 2020 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32196342
14.
Flavonoid-Derived Human Phenyl-γ-Valerolactone Metabolites Selectively Detoxify Amyloid-ß Oligomers and Prevent Memory Impairment in a Mouse Model of Alzheimer's Disease.
Mol Nutr Food Res
; 64(5): e1900890, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31914208
15.
Identification, Structure-Activity Relationship, and Biological Characterization of 2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indoles as a Novel Class of CFTR Potentiators.
J Med Chem
; 63(19): 11169-11194, 2020 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32946228
16.
5-(Hydroxyphenyl)-γ-Valerolactone-Sulfate, a Key Microbial Metabolite of Flavan-3-ols, Is Able to Reach the Brain: Evidence from Different in Silico, In Vitro and In Vivo Experimental Models.
Nutrients
; 11(11)2019 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31694297
17.
Phenyl-γ-valerolactones, flavan-3-ol colonic metabolites, protect brown adipocytes from oxidative stress without affecting their differentiation or function.
Mol Nutr Food Res
; 61(9)2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28276197
18.
Synthetic and analytical strategies for the quantification of phenyl-γ-valerolactone conjugated metabolites in human urine.
Mol Nutr Food Res
; 61(9)2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28440064
19.
Bioavailability of Black Tea Theaflavins: Absorption, Metabolism, and Colonic Catabolism.
J Agric Food Chem
; 65(26): 5365-5374, 2017 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28595385
20.
Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer.
Cell Rep
; 39(4): 110760, 2022 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35476990