Detalhe da pesquisa
1.
Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain.
Med Chem Res
; : 1-7, 2023 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37362320
2.
The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu4 PAM development candidate.
Bioorg Med Chem Lett
; 29(2): 342-346, 2019 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30503632
3.
Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu4 positive allosteric modulators that mitigate CYP1A2 induction liability.
Bioorg Med Chem Lett
; 28(15): 2641-2646, 2018 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29958762
4.
Preclinical Characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder.
J Pharmacol Exp Ther
; 363(3): 377-393, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28954811
5.
Synthesis and evaluation of prodrugs of corticotropin-releasing factor-1 (CRF1) receptor antagonist BMS-665053 leading to improved oral bioavailability.
Bioorg Med Chem Lett
; 27(6): 1360-1363, 2017 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28223020
6.
Triazolopyridine ethers as potent, orally active mGlu2 positive allosteric modulators for treating schizophrenia.
Bioorg Med Chem
; 25(2): 496-513, 2017 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27914948
7.
Synthesis and evaluation of carbamate and aryl ether substituted pyrazinones as corticotropin releasing factor-1 (CRF1) receptor antagonists.
Bioorg Med Chem Lett
; 26(9): 2184-7, 2016 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27020524
8.
Oxazolidinone-based allosteric modulators of mGluR5: Defining molecular switches to create a pharmacological tool box.
Bioorg Med Chem Lett
; 26(17): 4165-9, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27496211
9.
Difluorocyclobutylacetylenes as positive allosteric modulators of mGluR5 with reduced bioactivation potential.
Bioorg Med Chem Lett
; 26(24): 5871-5876, 2016 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27856084
10.
Biaryls as potent, tunable dual neurokinin 1 receptor antagonists and serotonin transporter inhibitors.
Bioorg Med Chem Lett
; 25(15): 3039-43, 2015 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26048800
11.
The discovery of potent agonists for GPR88, an orphan GPCR, for the potential treatment of CNS disorders.
Bioorg Med Chem Lett
; 25(7): 1443-7, 2015 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25754495
12.
Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88.
Bioorg Med Chem Lett
; 25(7): 1448-52, 2015 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25690789
13.
Empowering Voices: Inspiring Women in Medicinal Chemistry.
ACS Med Chem Lett
; 15(4): 424-431, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38628790
14.
Empowering Voices: Inspiring Women in Medicinal Chemistry.
J Med Chem
; 67(6): 4251-4258, 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38456628
15.
Potential CRF1R PET imaging agents: 1-fluoroalkylsubstituted 5-halo-3-(arylamino)pyrazin-2(1H)-ones.
Bioorg Med Chem Lett
; 23(7): 2052-5, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23465610
16.
Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression.
Bioorg Med Chem Lett
; 23(2): 407-11, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23253443
17.
2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as γ-secretase inhibitors.
Bioorg Med Chem Lett
; 22(22): 6828-31, 2012 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23046960
18.
Synthesis and structure-activity relationships of pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonists.
Bioorg Med Chem Lett
; 22(15): 4986-9, 2012 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22749422
19.
[18F](R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one: introduction of N3-phenylpyrazinones as potential CRF-R1 PET imaging agents.
Bioorg Med Chem Lett
; 22(21): 6651-5, 2012 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23010264
20.
Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors.
J Med Chem
; 65(5): 4121-4155, 2022 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35171586