Detalhe da pesquisa
1.
MAVEN: compound mechanism of action analysis and visualisation using transcriptomics and compound structure data in R/Shiny.
BMC Bioinformatics
; 24(1): 344, 2023 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37715141
2.
Benchmarking causal reasoning algorithms for gene expression-based compound mechanism of action analysis.
BMC Bioinformatics
; 24(1): 154, 2023 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37072707
3.
Two-Site Evaluation of the Repeatability and Precision of an Automated Dual-Column Hydrogen/Deuterium Exchange Mass Spectrometry Platform.
Anal Chem
; 88(12): 6607-14, 2016 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-27224086
4.
Conformational features of secondary N-cyclopropyl amides.
J Org Chem
; 80(8): 3914-20, 2015 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25803271
5.
The chemical basis of serine palmitoyltransferase inhibition by myriocin.
J Am Chem Soc
; 135(38): 14276-85, 2013 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23957439
6.
Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b.
Alzheimers Res Ther
; 15(1): 52, 2023 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36918909
7.
Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy.
NPJ Breast Cancer
; 8(1): 126, 2022 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-36446794
8.
The Angiopoietin-Like Protein 3 and 8 Complex Interacts with Lipoprotein Lipase and Induces LPL Cleavage.
ACS Chem Biol
; 16(3): 457-462, 2021 03 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33656326
9.
Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt).
J Med Chem
; 64(9): 5470-5484, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33852312
10.
A novel phage display vector for selection of target-specific peptides.
Protein Eng Des Sel
; 332020 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33009572
11.
Integration of phage and yeast display platforms: A reliable and cost effective approach for binning of peptides as displayed on-phage.
PLoS One
; 15(6): e0233961, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32479512
12.
High-throughput hydrogen bond strength calculation and its applications in optimizing drug ADME properties.
Future Med Chem
; 11(6): 511-524, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30892942
13.
A Decoupled Automation Platform for Hydrogen/Deuterium Exchange Mass Spectrometry Experiments.
J Am Soc Mass Spectrom
; 30(12): 2580-2583, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31724102
14.
The synthesis of azadirachtin: a potent insect antifeedant.
Chemistry
; 14(34): 10683-704, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18821532
15.
Deciphering Binding Interactions of IL-23R with HDX-MS: Mapping Protein and Macrocyclic Dodecapeptide Ligands.
ACS Med Chem Lett
; 9(9): 912-916, 2018 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30258540
16.
Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery.
PLoS One
; 13(1): e0190850, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29329326
17.
Assignment of absolute configuration on the basis of the conformational effects induced by chiral derivatizing agents: the 2-arylpyrrolidine case.
Org Lett
; 9(21): 4123-6, 2007 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-17887687
18.
A Residue-Resolved Bayesian Approach to Quantitative Interpretation of Hydrogen-Deuterium Exchange from Mass Spectrometry: Application to Characterizing Protein-Ligand Interactions.
J Phys Chem B
; 121(15): 3493-3501, 2017 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27807976
19.
Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences.
J Med Chem
; 60(23): 9807-9820, 2017 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29088532
20.
Author Correction: Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy.
NPJ Breast Cancer
; 8(1): 133, 2022 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36577758