Voluntary sterilisation and access to IVF in Québec.

Bill 20, An Act to Enact the Act to promote access to family medicine and specialized medicine services and to amend various legislative provisions relating to assisted procreation, was introduced to reduce costs associated with Québec's healthcare in general and in vitro fertilisation (IVF) in particular. Passed in November 2015, the new law introduces a number of exclusion criteria for access to and funding for IVF treatment. Remarkably, one exclusion criterion-prior voluntary sterilisation-has prompted little critical commentary. The two justifications offered for restricting funding for IVF on the basis of voluntary sterilisation are that (1) there are cheaper options than IVF for sterilised individuals who want children, and (2) society should not have to pay for IVF for persons who are infertile by choice. I argue that both of these justifications are unsatisfactory, insofar as they contravene the chief value underlying, and current practices of, Canadian healthcare, and rely on problematic ascriptions of personal responsibility for health.

The Measles and Free Riders.

This article takes up a game-theoretic perspective on California's recently passed bill (SB 277) that closes all nonmedical exemptions for school-mandated vaccination. Such a perspective characterizes parental decisions to vaccinate their children as a collective action problem and reveals the presence of an incentive to free ride-to enjoy the benefits of others' efforts to vaccinate their children without vaccinating one's own. This article defends California's legislation as a reasonable means of overcoming the free rider problem and of ensuring that the burdens of vaccination are shared equally.

Why governance? A challenge to good governance of biobanks.

In this commentary on Karla Stroud and Kieran O'Doherty's 'Ethically Sustainable Governance in the Biobanking of Eggs and Embryos for Research' (2015) I call into question the need for good governance to overcome the challenges facing biobanking of eggs and embryos. I argue that the principles of good governance for biobanking that Stroud and O'Doherty outline come up short in providing concrete normative guidance to resolve the challenges associated with a biobank for eggs and embryos.

Structural and functional analysis of the putative pH sensor in the Kir1.1 (ROMK) potassium channel.

The pH-sensitive renal potassium channel Kir1.1 is important for K+ homeostasis. Disruption of the pH-sensing mechanism causes type II Bartter syndrome. The pH sensor is thought to be an anomalously titrated lysine residue (K80) that interacts with two arginine residues as part of an 'RKR triad'. We show that a Kir1.1 orthologue from Fugu rubripes lacks this lysine and yet is still highly pH sensitive, indicating that K80 is not the H+ sensor. Instead, K80 functionally interacts with A177 on transmembrane domain 2 at the 'helix-bundle crossing' and controls the ability of pH-dependent conformational changes to induce pore closure. Although not required for pH inhibition, K80 is indispensable for the coupling of pH gating to the extracellular K+ concentration, explaining its conservation in most Kir1.1 orthologues. Furthermore, we demonstrate that instead of interacting with K80, the RKR arginine residues form highly conserved inter- and intra-subunit interactions that are important for Kir channel gating and influence pH sensitivity indirectly.