Detalhe da pesquisa
1.
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A.
Nature
; 603(7899): 131-137, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35197628
2.
Comprehensive splicing analysis of the alternatively spliced CHEK2 exons 8 and 10 reveals three enhancer/silencer-rich regions and 38 spliceogenic variants.
J Pathol
; 262(4): 395-409, 2024 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38332730
3.
Cross-seeding by prion protein inactivates TDP-43.
Brain
; 147(1): 240-254, 2024 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37669322
4.
Mitigation of TDP-43 toxic phenotype by an RGNEF fragment in amyotrophic lateral sclerosis models.
Brain
; 2024 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38739752
5.
Phe-Gly motifs drive fibrillization of TDP-43's prion-like domain condensates.
PLoS Biol
; 19(4): e3001198, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33909608
6.
Detection of TDP-43 seeding activity in the olfactory mucosa from patients with frontotemporal dementia.
Alzheimers Dement
; 20(2): 1156-1165, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37908186
7.
Unraveling the toxic effects mediated by the neurodegenerative disease-associated S375G mutation of TDP-43 and its S375E phosphomimetic variant.
J Biol Chem
; 298(8): 102252, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35835219
8.
Early neurotransmitters changes in prodromal frontotemporal dementia: A GENFI study.
Neurobiol Dis
; 179: 106068, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36898614
9.
Reviewing the Potential Links between Viral Infections and TDP-43 Proteinopathies.
Int J Mol Sci
; 24(2)2023 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36675095
10.
TDP-43 Epigenetic Facets and Their Neurodegenerative Implications.
Int J Mol Sci
; 24(18)2023 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37762112
11.
Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis.
EMBO J
; 37(11)2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29764981
12.
Distinguishing post-translational modifications in dominantly inherited frontotemporal dementias: FTLD-TDP Type A (GRN) vs Type B (C9orf72).
Neuropathol Appl Neurobiol
; 48(6): e12836, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35836354
13.
Optineurin Deficiency and Insufficiency Lead to Higher Microglial TDP-43 Protein Levels.
Int J Mol Sci
; 23(12)2022 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35743272
14.
Aromatic and aliphatic residues of the disordered region of TDP-43 are on a fast track for self-assembly.
Biochem Biophys Res Commun
; 578: 110-114, 2021 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34560580
15.
HnRNP K mislocalisation is a novel protein pathology of frontotemporal lobar degeneration and ageing and leads to cryptic splicing.
Acta Neuropathol
; 142(4): 609-627, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34274995
16.
Somatic TARDBP variants as a cause of semantic dementia.
Brain
; 143(12): 3827-3841, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33155043
17.
Trends in Understanding the Pathological Roles of TDP-43 and FUS Proteins.
Adv Exp Med Biol
; 1281: 243-267, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33433879
18.
Antibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD-TDP subtypes.
Acta Neuropathol
; 140(5): 645-658, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32778941
19.
Mis-splicing in breast cancer: identification of pathogenic BRCA2 variants by systematic minigene assays.
J Pathol
; 248(4): 409-420, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30883759
20.
Autoregulation of TDP-43 mRNA levels involves interplay between transcription, splicing, and alternative polyA site selection.
Genes Dev
; 26(15): 1679-84, 2012 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22855830