Detalhe da pesquisa
1.
Interactions of dopamine, iron, and alpha-synuclein linked to dopaminergic neuron vulnerability in Parkinson's disease and Neurodegeneration with Brain Iron Accumulation disorders.
Neurobiol Dis
; 175: 105920, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36351559
2.
Modeling Brain Pathology of Niemann-Pick Disease Type C Using Patient-Derived Neurons.
Mov Disord
; 36(4): 1022-1027, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33438272
3.
Acid ceramidase inhibition ameliorates α-synuclein accumulation upon loss of GBA1 function.
Hum Mol Genet
; 27(11): 1972-1988, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29579237
4.
The role of dopamine in the pathogenesis of GBA1-linked Parkinson's disease.
Neurobiol Dis
; 132: 104545, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31351996
5.
Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells.
Brain
; 141(10): 3052-3064, 2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30169597
6.
Activation of ß-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.
J Neurosci
; 36(29): 7693-706, 2016 07 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27445146
7.
Detection of Free and Protein-Bound ortho-Quinones by Near-Infrared Fluorescence.
Anal Chem
; 88(4): 2399-405, 2016 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26813311
8.
A novel heterozygous OPA3 mutation located in the mitochondrial target sequence results in altered steady-state levels and fragmented mitochondrial network.
J Med Genet
; 50(12): 848-58, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24136862
9.
Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis.
Hum Mol Genet
; 19(22): 4437-52, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20817635
10.
Genome-wide Association and Meta-analysis of Age at Onset in Parkinson Disease: Evidence From the COURAGE-PD Consortium.
Neurology
; 99(7): e698-e710, 2022 08 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35970579
11.
Identification of ASCL1 as a determinant for human iPSC-derived dopaminergic neurons.
Sci Rep
; 11(1): 22257, 2021 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34782629
12.
Mitochondrial Phenotypes in Parkinson's Diseases-A Focus on Human iPSC-Derived Dopaminergic Neurons.
Cells
; 10(12)2021 12 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34943944
13.
Direct targeting of wild-type glucocerebrosidase by antipsychotic quetiapine improves pathogenic phenotypes in Parkinson's disease models.
JCI Insight
; 6(19)2021 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34622801
14.
Balance is the challenge--the impact of mitochondrial dynamics in Parkinson's disease.
Eur J Clin Invest
; 40(11): 1048-60, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20735469
15.
The Convergence of Alpha-Synuclein, Mitochondrial, and Lysosomal Pathways in Vulnerability of Midbrain Dopaminergic Neurons in Parkinson's Disease.
Front Cell Dev Biol
; 8: 580634, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33381501
16.
Gelator length precisely tunes supramolecular hydrogel stiffness and neuronal phenotype in 3D culture.
ACS Biomater Sci Eng
; 6(2): 1196-1207, 2020 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33094153
17.
Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain.
Nat Neurosci
; 23(1): 15-20, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31844313
18.
Author Correction: Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain.
Nat Neurosci
; 23(2): 293, 2020 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-31911656
19.
A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease.
Sci Transl Med
; 12(560)2020 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32908004
20.
A modulator of wild-type glucocerebrosidase improves pathogenic phenotypes in dopaminergic neuronal models of Parkinson's disease.
Sci Transl Med
; 11(514)2019 10 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31619543