Detalhe da pesquisa
1.
BTK inhibition limits B-cell-T-cell interaction through modulation of B-cell metabolism: implications for multiple sclerosis therapy.
Acta Neuropathol
; 143(4): 505-521, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35303161
2.
MOG autoantibodies trigger a tightly-controlled FcR and BTK-driven microglia proliferative response.
Brain
; 144(8): 2361-2374, 2021 09 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34145876
3.
Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76.
Immunity
; 28(3): 359-69, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18342008
4.
The SLP-76 Src homology 2 domain is required for T cell development and activation.
J Immunol
; 187(9): 4459-66, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21949020
5.
T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool.
Blood
; 116(25): 5548-59, 2010 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-20847203
6.
Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis.
J Med Chem
; 65(2): 1206-1224, 2022 01 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34734694
7.
Isolation of Microglia and Analysis of Protein Expression by Flow Cytometry: Avoiding the Pitfall of Microglia Background Autofluorescence.
Bio Protoc
; 11(14): e4091, 2021 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34395729
8.
Next-generation Bruton's tyrosine kinase inhibitor BIIB091 selectively and potently inhibits B cell and Fc receptor signaling and downstream functions in B cells and myeloid cells.
Clin Transl Immunology
; 10(6): e1295, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34141433
9.
Organotypic Brain Slice Culture Microglia Exhibit Molecular Similarity to Acutely-Isolated Adult Microglia and Provide a Platform to Study Neuroinflammation.
Front Cell Neurosci
; 14: 592005, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33473245
10.
Identification of Candidate Tolerogenic CD8(+) T Cell Epitopes for Therapy of Type 1 Diabetes in the NOD Mouse Model.
J Diabetes Res
; 2016: 9083103, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27069933
11.
Protocadherin-18 is a novel differentiation marker and an inhibitory signaling receptor for CD8+ effector memory T cells.
PLoS One
; 7(5): e36101, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22567129