Detalhe da pesquisa
1.
Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection.
Proc Natl Acad Sci U S A
; 120(11): e2219523120, 2023 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36893269
2.
Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity.
Nucleic Acids Res
; 49(21): 12069-12088, 2021 12 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34850120
3.
Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles.
Mol Ther
; 29(4): 1382-1394, 2021 04 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33348054
4.
The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy.
Nucleic Acids Res
; 48(14): 7665-7680, 2020 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32672813
5.
Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in mouse and pig photoreceptors.
Mol Ther Nucleic Acids
; 35(1): 102088, 2024 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38192611
6.
Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in rodent and swine photoreceptors.
bioRxiv
; 2023 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37790464
7.
Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo.
Res Sq
; 2023 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37398145
8.
Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo.
bioRxiv
; 2023 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37292886
9.
PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs.
Mol Ther Nucleic Acids
; 29: 116-132, 2022 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35795486
10.
Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep.
JCI Insight
; 6(24)2021 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34935646