Detalhe da pesquisa
1.
Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity.
Bioorg Med Chem Lett
; 28(2): 85-93, 2018 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29233651
2.
Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors.
Bioorg Med Chem Lett
; 26(23): 5729-5731, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27816517
3.
The discovery of BMS-457, a potent and selective CCR1 antagonist.
Bioorg Med Chem Lett
; 23(13): 3833-40, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23707259
4.
Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine ß-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors.
J Med Chem
; 59(18): 8593-600, 2016 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27559936
5.
Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aß Reduction in Rodents.
ACS Med Chem Lett
; 7(3): 271-6, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26985314