Detalhe da pesquisa
1.
Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice.
Pharm Res
; 40(11): 2555-2566, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37442882
2.
Topotecan clearance based on a single sample and a population pharmacokinetic model: Application to a pediatric high-risk neuroblastoma clinical trial.
Pediatr Blood Cancer
; 70(11): e30658, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37664968
3.
Development and Validation of a Sensitive and Specific LC-MS/MS Method for IWR-1-Endo, a Wnt Signaling Inhibitor: Application to a Cerebral Microdialysis Study.
Molecules
; 27(17)2022 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36080214
4.
A phase I trial of the CDK 4/6 inhibitor palbociclib in pediatric patients with progressive brain tumors: A Pediatric Brain Tumor Consortium study (PBTC-042).
Pediatr Blood Cancer
; 68(4): e28879, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33405376
5.
A phase 1 trial of everolimus and bevacizumab in children with recurrent solid tumors.
Cancer
; 126(8): 1749-1757, 2020 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31967673
6.
Pharmacokinetic basis for dosing high-dose methotrexate in infants and young children with malignant brain tumours.
Br J Clin Pharmacol
; 86(2): 362-371, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31657864
7.
An LC/ESI-MS/MS method to quantify the PI3K inhibitor GDC-0084 in human plasma and cerebrospinal fluid: Validation and clinical application.
Biomed Chromatogr
; 34(1): e4697, 2020 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-31495945
8.
Lorlatinib in a Child with ALK-Fusion-Positive High-Grade Glioma.
N Engl J Med
; 385(8): 761-763, 2021 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34407349
9.
The impact of tacrolimus exposure on extrarenal adverse effects in adult renal transplant recipients.
Br J Clin Pharmacol
; 85(3): 516-529, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30414331
10.
CNS Penetration of Cyclophosphamide and Metabolites in Mice Bearing Group 3 Medulloblastoma and Non-Tumor Bearing Mice.
J Pharm Pharm Sci
; 22(1): 612-629, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31815662
11.
Advancing clinical development for neuronopathic Hunter syndrome through a quantitatively-driven reverse translation framework.
Clin Transl Sci
; 17(4): e13776, 2024 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38545863
12.
Population pharmacokinetics of methotrexate and 7-hydroxymethotrexate and delayed excretion in infants and young children with brain tumors.
Eur J Pharm Sci
; 193: 106669, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38070781
13.
CNS penetration of methotrexate and its metabolite 7-hydroxymethotrexate in mice bearing orthotopic Group 3 medulloblastoma tumors and model-based simulations for children.
Drug Metab Pharmacokinet
; 48: 100471, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36669926
14.
Model-Informed Approaches and Innovative Clinical Trial Design for Adeno-Associated Viral Vector-Based Gene Therapy Product Development: A White Paper.
Clin Pharmacol Ther
; 114(3): 515-529, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37313953
15.
Phase II study of alisertib as a single agent for treating recurrent or progressive atypical teratoid/rhabdoid tumor.
Neuro Oncol
; 25(2): 386-397, 2023 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35652336
16.
Population pharmacokinetics of crenolanib in children and young adults with brain tumors.
Cancer Chemother Pharmacol
; 89(4): 459-468, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35212779
17.
Combination of Ribociclib and Gemcitabine for the Treatment of Medulloblastoma.
Mol Cancer Ther
; 21(8): 1306-1317, 2022 08 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35709750
18.
Phase I study of ribociclib and everolimus in children with newly diagnosed DIPG and high-grade glioma: A CONNECT pediatric neuro-oncology consortium report.
Neurooncol Adv
; 4(1): vdac055, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35611273
19.
Clinical Pharmacokinetics and Pharmacodynamics of Selumetinib.
Clin Pharmacokinet
; 60(3): 283-303, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33354735
20.
Development and validation of an LC-MS/MS method to quantify the bromodomain and extra-terminal (BET) inhibitor JQ1 in mouse plasma and brain microdialysate: Application to cerebral microdialysis study.
J Pharm Biomed Anal
; 204: 114274, 2021 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34311284