RESUMO
In order to analyze the association between body mass index (BMI), lipid profile and clinical symptoms in patients with fibromyalgia, we assessed BMI levels, lipid profile and its association with clinical symptoms in 183 patients with fibromyalgia. The patients were evaluated using tender points, FIQ and Visual Analogue Scales of pain (VAS). Serum lipid profile analysis (total cholesterol, triglyceride, HDL, LDL and VLDL), and biochemical parameters were measured in the biochemistry laboratory. The BMI distribution of the nonobese, overweight and obese patients' groups were relatively even with 37.7, 35.5 and 26.8%, respectively, with a mean BMI of 27.3 ± 4.9. The number of tender points showed significantly positive correlation with higher BMI (P < 0.05). A total of 57.9% of patients showed increased levels of total cholesterol, 63.4 % increased levels of LDL cholesterol and 19.9% high levels of triglycerides. BMI, total cholesterol and triglycerides showed high association with some clinical parameters. Overweight and lipid profile could be associated with fibromyalgia symptoms. A treatment program with weight loss strategies, and control in diet and increased physical activity is advised to patients.
Assuntos
Fibromialgia/sangue , Fibromialgia/fisiopatologia , Lipídeos/sangue , Obesidade/sangue , Obesidade/fisiopatologia , Sobrepeso/sangue , Sobrepeso/fisiopatologia , Adulto , Índice de Massa Corporal , Colesterol/sangue , HDL-Colesterol/sangue , LDL-Colesterol/sangue , Dieta Redutora , Exercício Físico , Feminino , Fibromialgia/terapia , Humanos , Masculino , Pessoa de Meia-Idade , Mialgia/fisiopatologia , Obesidade/terapia , Sobrepeso/terapia , Medição da Dor , Triglicerídeos/sangueRESUMO
This overview of reviews aimed to summarize the evidence from systematic reviews and meta-analyses of randomized clinical trials of the efficacy of acceptance and commitment therapy (ACT) for adults with chronic pain in relation to pain intensity, pain-related functioning, quality of life, and psychological factors. The Cumulative Index of Nursing and Allied Health Literature (CINAHL), Embase, PsycINFO, PubMed, and the Cochrane Library databases were searched from inception to July 2, 2023. AMSTAR 2 was used to assess the methodological quality of systematic reviews. The overlap among reviews was calculated. Nine reviews comprising 84 meta-analyses of interest were included. At post-treatment, some meta-analyses mainly showed that ACT can reduce depression symptoms, anxiety symptoms, psychological inflexibility, and pain catastrophizing; and can improve mindfulness, pain acceptance, and psychological flexibility. At three-month follow-up, ACT can reduce depression symptoms and psychological inflexibility, as well as improve pain-related functioning and psychological flexibility. At six-month follow-up, ACT can improve mindfulness, pain-related functioning, pain acceptance, psychological flexibility, and quality of life. At six-twelve-month follow-up, ACT can reduce pain catastrophizing and can improve pain-related functioning. Some methodological and clinical issues are identified in the reviews, such as a very high overlap between systematic reviews, the fact that the certainty of the evidence is often not rated and specific details needed to replicate the interventions reviewed are often not reported. Overall, however, randomized clinical trials and systematic reviews show that ACT can improve outcomes related to chronic pain (eg, pain-related functioning). Future systematic reviews should address the methodological and clinical concerns identified here to produce higher-quality findings. PERSPECTIVE: Despite certain methodological and clinical issues, randomized clinical trials and systematic reviews of ACT appear to show that it can improve outcomes related to chronic pain (eg, psychological factors).
Assuntos
Terapia de Aceitação e Compromisso , Dor Crônica , Adulto , Humanos , Dor Crônica/terapia , Dor Crônica/psicologia , Qualidade de Vida , Ensaios Clínicos Controlados Aleatórios como AssuntoRESUMO
BACKGROUND AND OBJECTIVE: Further questions need to be addressed in the evaluation of locus of control (LOC) in headaches, such as reducing scale length and adapting them to diverse cultural environments, as in the case of Spain. METHODS: We perform a confirmatory factor analysis of the most outstanding items contained in the Headache-Specific Locus of Control Scale in the responses of 118 patients suffering from headaches who received assistance at public health care centers in the province of Seville (Spain). RESULTS: The adjustment was positive, thus confirming the original structure of 3 factors: internal locus of control (LOC-I), health care professionals' LOC, and chance locus of control (LOC-C). Scale validation was performed by examining associations both with headache clinical parameters and psychological measures. The latter included self-efficacy, internal language, coping strategies, and pain behaviors. LOC-C results deserve special mention, supporting the idea that it seems more important to avoid that patients develop LOC-C rather than boosting LOC-I and LOC-P expectations. CONCLUSIONS: The so-called Headache-Specific Locus of Control Scale-Short Form 9 has turned out to be a parsimonious (9 items), valid, and reliable measure of headache LOC.
Assuntos
Transtornos da Cefaleia/diagnóstico , Transtornos da Cefaleia/psicologia , Controle Interno-Externo , Testes Neuropsicológicos/normas , Inquéritos e Questionários/normas , Adolescente , Adulto , Feminino , Transtornos da Cefaleia/etnologia , Humanos , Masculino , Pessoa de Meia-Idade , Espanha/epidemiologia , Espanha/etnologia , Adulto JovemRESUMO
AIM: In common clinical practice, potentially traumatic life events and the possible attribution of such events to fibromyalgia often go undetected. Having demonstrated in a previous study that hypnosis facilitates the exploration of such events, we now aim to explore and classify the content of these events and to determine whether there is an association between the type of event, the state of consciousness in which the patient verbalized it, and possible causal attributions of the disorder. METHOD: Thirty-two women (age 52 ± 7 years) suffering from fibromyalgia and receiving care in a primary healthcare center participated in the same semi-structured interview twice: once in a wakeful state and once under hypnosis. They answered two questions: what other events in your life coincided with the onset of fibromyalgia? Are those events related to your fibromyalgia in any way? To counteract biases related to order or recall, the order of the two interviews was randomized with a 3-month period in between. RESULTS: The patients verbalized 23 different types of events, which we classified into eight categories, mostly psychosocial events. Although the relationship between the three variables was not statistically significant, two of the bivariate associations predicted (type of event and state of consciousness; and state of consciousness and causal attribution) were confirmed (χ2 , P values of .01 and <.001 respectively). CONCLUSION: Potentially traumatic life events could remain undetected in primary healthcare consultations and hypnosis could prove a useful tool for their detection.
Assuntos
Fibromialgia/etiologia , Hipnose , Acontecimentos que Mudam a Vida , Estresse Psicológico/complicações , Estado de Consciência , Feminino , Fibromialgia/diagnóstico , Fibromialgia/psicologia , Humanos , Entrevistas como Assunto , Estudos Longitudinais , Pessoa de Meia-Idade , Medição de Risco , Fatores de Risco , Estresse Psicológico/diagnóstico , Estresse Psicológico/psicologia , Fatores de TempoRESUMO
Background: Though the Spanish version of the Coping Strategies Inventory (CSI) is frequently used, it has not been subjected to any significant re-evaluation from a psychometric perspective. Method: We analysed CSI data that was focused on an academic stress situation, using a university sample of 874 participants, 50% of each gender. We conducted reliability, confirmatory factor, and factorial invariance across gender analyses. Results: The first-order factorial structure was confirmed, showing an adequate fit for the eight-factor coping strategies model with good reliability indices. Neither the second-order (problem-centred vs. emotion-centred) nor third-order (engagement vs. disengagement) strategies showed an adequate fit. Factorial invariance for gender was confirmed. Conclusions: The theoretical and applied implications of the results are discussed.(AU)
Antecedentes: Aunque la versión española del del Inventario de Estrategias de Afrontamiento (CSI) se usa frecuentemente, no se ha sometido a reevaluación psicométrica. Método: Analizamos datos del CSI aplicados a situaciones de estrés académico utilizando una muestra universitaria de 874 participantes, 50% de cada género. Llevamos a cabo análisis de fiabilidad, confirmatorios y de invarianza factorial por género. Resultados: Se confirmó la estructura factorial de primer orden, mostrando un ajuste adecuado el modelo de 8 estrategias de afrontamiento, con buenos índices de fiabilidad. No mostraron un ajuste adecuado las factorizaciones de segundo orden (centrado en el problema o en la emoción) ni de tercer orden (compromiso o retirada). Se confirmó la invarianza factorial por género. Conclusiones: Se discuten las implicaciones teóricas y aplicadas de los resultados.(AU)
Assuntos
Humanos , Masculino , Feminino , Estresse Psicológico , Adaptação Psicológica , Análise Fatorial , PsicometriaRESUMO
Background: Technology anxiety is more prevalent in older people and can compromise their functionality in an increasingly techno-dependent world. There are no validated instruments to assess it in older Spanish people. Method: A technology anxiety scale was cross-culturally adapted and applied to 355 Spaniards (66% women, M = 78.63, SD = 6.77). Two models were tested by confirmatory factor analysis: a one-dimensional model (technology anxiety) and a model with two correlated factors (fear and confidence in technology, respectively). Results: Both showed an adequate fit, although higher in the two-factor correlated model (χ2 = 243.797, df = 26, CFI = .969, TLI = .945, SRMR = .039). Concurrent validity was confirmed through correlations with psychological well-being, quality of life, and health satisfaction. Configural, metric, and scalar factorial gender invariance were also verified. Conclusion: Our data support the preliminary validity of the Technology Anxiety Scale in older Spanish men and women. (AU)
Introducción: La ansiedad tecnológica es más prevalente en mayores y puede dificultar su funcionalidad en un mundo cada vez más tecnodependiente. No hay instrumentos validados para evaluarla en mayores españoles. Método: Se adaptó transculturalmente una escala de ansiedad tecnológica y se aplicó a 355 españoles (66% mujeres, M = 78,63, DT = 6,77). Se testaron dos modelos mediante análisis factorial confirmatorio: un modelo unidimensional (ansiedad tecnológica) y un modelo con dos factores correlacionados (miedo a la tecnología y confianza en la misma). Resultados: Ambos mostraron un ajuste adecuado, aunque mayor en el modelo de dos factores correlacionados (χ2 = 243,797, gl = 26, CFI = .969, TLI = .945, SRMR = .039). La validez concurrente se confirmó mediante correlaciones con bienestar psicológico, calidad de vida y satisfacción con la salud. También se verificó la invarianza de género configural, métrica y escalar. Conclusión: Los resultados confirman la validez preliminar de la Escala de Ansiedad Tecnológica en hombres y mujeres mayores españoles. (AU)
Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Ansiedade/epidemiologia , Tecnologia/tendências , Espanha , Ansiedade/psicologia , Análise Fatorial , EnvelhecimentoRESUMO
According to evidence from recent decades, multicomponent programs of psychological intervention in people with chronic pain have reached the highest levels of efficacy. However, there are still many questions left to answer since efficacy has mainly been shown among upper-middle class patients in English-speaking countries and in controlled studies, with expert professionals guiding the intervention and with a limited number of domains of painful experience evaluated. For this study, a program of multicomponent psychological intervention was implemented: (a) based on techniques with empirical evidence, but developed in Spain; (b) at a public primary care center; (c) among patients with limited financial resources and lower education; (d) by a novice psychologist; and (e) evaluating all domains of painful experience using the instruments recommended by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT). The aim of this study was to evaluate this program. We selected a consecutive sample of 40 patients treated for chronic non-cancer pain at a primary care center in Utrera (Seville, Spain), adults who were not in any employment dispute, not suffering from psychopathology, and not receiving psychological treatment. The patients participated in 10 psychological intervention sessions, one per week, in groups of 13-14 people, which addressed psychoeducation for pain; breathing and relaxation; attention management; cognitive restructuring; problem-solving; emotional management; social skills; life values and goal setting; time organization and behavioral activation; physical exercise promotion; postural and sleep hygiene; and relapse prevention. In addition to the initial assessment, measures were taken after the intervention and at a 6-month follow-up. We assessed the program throughout the process: before, during and after the implementation. Results were analyzed statistically (significance and effect size) and from a clinical perspective (clinical significance according to IMMPACT standards). According to this analysis, the intervention was successful, although improvement tended to decline at follow-up, and the detailed design gave the program assessment a high degree of standardization and specification. Finally, suggestions for improvement are presented for upcoming applications of the program.
RESUMO
Conventional cardiovascular risk factors (CVRFs) are accepted to identify asymptomatic individuals with high risk of acute myocardial infarction (AMI). However, AMI affects many patients previously classified at low risk. New biomarkers are needed to improve risk prediction. We propose to evaluate the NLRP3-inflammasome complex as a potential conventional cardiovascular risk (CVR) indicator in healthy males and post-AMI patients and compare both groups by known CVRFs. We included 109 men with no history of cardiovascular disease (controls) and 150 AMI patients attending a cardiac rehabilitation program. AMI patients had higher mean of body mass index (BMI) and waist circumference than the controls. However, high percentages of the controls had a high BMI and a waist circumference >95 cm. The controls also had higher systolic blood pressure (p > 0.001), total and low-density lipoprotein cholesterol, dietary nutrient, and calorific intake. Fuster BEWAT score (FBS) correlated more closely than Framingham risk score (FRS) with most CVRF, groups. However, only the FBS showed a correlation with inflammasome cytokine interleukin 1ß (IL-1ß). Several CVRFs were significantly better in AMI patients; however, this group also had higher mRNA expression of the inflammasome gene NLRP3 and lower expression of the autophagy gene MAP-LC3. The controls had high levels of CVRF, probably reflecting unhealthy lifestyle. FBS reflects the efficiency of strategies to induce lifestyle changes such as cardiac rehabilitation programs, and could provide a sensitive evaluation CVR. These results lead to the hypothesis that NLRP3-inflammasome and associated IL-1ß release have potential as CVR biomarkers, particularly in post-AMI patients with otherwise low risk scores. Antioxid. Redox Signal. 27, 269-275.
Assuntos
Inflamassomos/metabolismo , Infarto do Miocárdio/metabolismo , Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo , Adulto , Idoso , Biomarcadores , Pressão Sanguínea/fisiologia , Índice de Massa Corporal , Humanos , Inflamassomos/sangue , Interleucina-1beta/metabolismo , Lipoproteínas LDL/metabolismo , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/imunologia , Infarto do Miocárdio/patologia , Proteína 3 que Contém Domínio de Pirina da Família NLR/genética , Fatores de RiscoRESUMO
Studies of the dimensionality of the Life Orientation Test-Revised (LOT-R), considered as the gold standard in the measurement of dispositional optimism, yield controversial results due to the various factorial solutions found. Consequently, the factorial structure of the test has not yet been fully established. The aim of this study is to determine the factorial structure of the LOT-R by comparing seven previous models and their empirical evidence. The test was administered to 906 Spanish participants, ages 18 to 61 (mean age: 23; 56% males). Confirmatory factor analyses were conducted using polychoric correlations. Considering the theoretical background and the best model fit indices (RMSEA=.038; CFI=.98), we conclude that the test presents a factorial structure of a second-order factor (life orientation) composed of two factors (optimism and pessimism). Thus, we recommend using a single global score that could be referred to as life orientation but which ultimately represents the level of dispositional optimism.
Los estudios sobre la dimensionalidad del Test de Orientación Vital-Revisado (LOT-R), considerado el estándar en la medida del optimismo disposicional, resultan controvertidos al encontrar diversas soluciones factoriales. Así, no se ha establecido la estructura factorial definitiva de la prueba. El objetivo del presente estudio es determinar la estructura factorial del LOT-R mediante la comparación de los siete modelos empíricos existentes en la literatura. El instrumento fue administrado a 906 participantes españoles, de edades comprendidas entre los 18 y los 61 años (edad media = 23; 56% hombres). Se llevaron a cabo análisis factoriales confirmatorios sobre la matriz de correlaciones policóricas. Teniendo en cuenta los modelos teóricos existentes y los mejores índices de ajuste (RMSEA = 0,038; CFI = 0,98), concluimos que el LOT-R presenta una estructura factorial de segundo orden (orientación vital), compuesta por dos factores (Optimismo y Pesimismo). En consecuencia, recomendamos utilizar una única puntuación global que puede denominarse orientación vital y que, en último término, representa el nivel de optimismo disposicional.
Assuntos
Adiposidade , Doenças Cardiovasculares/fisiopatologia , Metabolismo Energético , Inflamação/fisiopatologia , Obesidade/fisiopatologia , Fatores Etários , Biomarcadores/sangue , Doenças Cardiovasculares/sangue , Doenças Cardiovasculares/diagnóstico , Doenças Cardiovasculares/epidemiologia , Nível de Saúde , Humanos , Inflamassomos/metabolismo , Inflamação/sangue , Inflamação/diagnóstico , Inflamação/epidemiologia , Mediadores da Inflamação/sangue , Interleucina-1beta/sangue , Masculino , Obesidade/sangue , Obesidade/diagnóstico , Obesidade/epidemiologia , Valor Preditivo dos Testes , Prognóstico , Medição de Risco , Fatores de Risco , Espanha/epidemiologiaRESUMO
BACKGROUND: We examined lipid peroxidation (LPO) in blood mononuclear cells (BMCs) and plasma, as a marker of oxidative damage, and its association to clinical symptoms in Fibromyalgia (FM) patients. METHODS: We conducted a case-control and correlational study comparing 65 patients and 45 healthy controls. Clinical parameters were evaluated using the Fibromyalgia Impact Questionnaire (FIQ), visual analogues scales (VAS), and the Beck Depression Inventory (BDI). Oxidative stress was determined by measuring LPO in BMCs and plasma. RESULTS: We found increased LPO levels in BMCs and plasma from FM patients as compared to normal control (P<0.001). A significant correlation between LPO in BMCs and clinical parameters was observed (r = 0.584, P<0.001 for VAS; r = 0.823, P<0.001 for FIQ total score; and r = 0.875, P<0.01 for depression in the BDI). We also found a positive correlation between LPO in plasma and clinical symptoms (r = 0.452, P<0.001 for VAS; r = 0.578, P<0.001 for FIQ total score; and r = 0.579, P<0.001 for depression in the BDI). Partial correlation analysis controlling for age and BMI, and sex, showed that both LPO in cells and plasma were independently associated to clinical symptoms. However, LPO in cells, but not LPO in plasma, was independently associated to clinical symptoms when controlling for depression (BDI scores). DISCUSSION: The results of this study suggest a role for oxidative stress in the pathophysiology of fibromyalgia and that LPO in BMCs rather than LPO in plasma is better associated to clinical symptoms in FM.
Assuntos
Fibromialgia/fisiopatologia , Leucócitos Mononucleares/metabolismo , Peroxidação de Lipídeos , Plasma/metabolismo , Adulto , Células Sanguíneas , Estudos de Casos e Controles , Feminino , Fibromialgia/metabolismo , Humanos , Masculino , Pessoa de Meia-Idade , Estresse OxidativoRESUMO
Studies of the dimensionality of the Life Orientation Test-Revised (LOT-R), considered as the gold standard in the measurement of dispositional optimism, yield controversial results due to the various factorial solutions found. Consequently, the factorial structure of the test has not yet been fully established. The aim of this study is to determine the factorial structure of the LOT-R by comparing seven previous models and their empirical evidence. The test was administered to 906 Spanish participants, ages 18 to 61 (mean age: 23; 56% males). Confirmatory factor analyses were conducted using polychoric correlations. Considering the theoretical background and the best model fit indices (RMSEA=.038; CFI=.98), we conclude that the test presents a factorial structure of a second-order factor (life orientation) composed of two factors (optimism and pessimism). Thus, we recommend using a single global score that could be referred to as life orientation but which ultimately represents the level of dispositional optimism (AU)
Los estudios sobre la dimensionalidad del Test de Orientación Vital-Revisado (LOT-R), considerado el estándar en la medida del optimismo disposicional, resultan controvertidos al encontrar diversas soluciones factoriales. Así, no se ha establecido la estructura factorial definitiva de la prueba. El objetivo del presente estudio es determinar la estructura factorial del LOT-R mediante la comparación de los siete modelos empíricos existentes en la literatura. El instrumento fue administrado a 906 participantes españoles, de edades comprendidas entre los 18 y los 61 años (edad media = 23; 56% hombres). Se llevaron a cabo análisis factoriales confirmatorios sobre la matriz de correlaciones policóricas. Teniendo en cuenta los modelos teóricos existentes y los mejores índices de ajuste (RMSEA = 0,038; CFI = 0,98), concluimos que el LOT-R presenta una estructura factorial de segundo orden (orientación vital), compuesta por dos factores (Optimismo y Pesimismo). En consecuencia, recomendamos utilizar una única puntuación global que puede denominarse orientación vital y que, en último término, representa el nivel de optimismo disposicional (AU)