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1.
Int J Gynecol Cancer ; 25(8): 1513-8, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26397069

RESUMO

OBJECTIVE: This retrospective study aimed to compare the sentinel lymph node (SLN) mapping results of methylene blue (MB) and indocyanine green (ICG) in women with early-stage endometrial or cervical cancer. METHODS: From August 2011 to March 2015, all consecutive patients with stage I endometrial or cervical cancer who underwent SLN mapping with intracervical injection of MB or ICG using a 22-gauge spinal needle were included in the study. Radical or simple hysterectomy with bilateral pelvic and/or aortic lymphadenectomy was performed after SLN mapping. RESULTS: Overall, 81 women (64 women with endometrial cancer and 17 women with cervical cancer) underwent surgery, including SLN mapping. Sixty-five patients (80%) underwent minimally invasive surgery. The overall detection rate was 84% (34 of 38) and 100% (43 of 43) for MB and ICG, respectively (P = 0.041). Bilateral SLN detection was higher in the ICG group than in the MB group (88% vs 50; P = 0.002). Eleven patients (13.5%) were found to have positive nodes with at least 1 positive SLN. The sensitivity and negative predictive value of SLN were 100%. CONCLUSIONS: Real-time florescence mapping with ICG shows better overall detection rate and bilateral mapping than MB alone. In our pilot study, the differences are statistically significant. The higher number of bilateral mapping of ICG may increase the quality of life and recovery of women by reducing the need for complete lymphadenectomy.


Assuntos
Corantes/metabolismo , Neoplasias do Endométrio/patologia , Verde de Indocianina/metabolismo , Azul de Metileno/metabolismo , Biópsia de Linfonodo Sentinela/normas , Neoplasias Uterinas/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Neoplasias do Endométrio/metabolismo , Neoplasias do Endométrio/cirurgia , Feminino , Fluorescência , Seguimentos , Humanos , Histerectomia , Metástase Linfática , Pessoa de Meia-Idade , Gradação de Tumores , Invasividade Neoplásica , Estadiamento de Neoplasias , Prognóstico , Estudos Prospectivos , Qualidade de Vida , Espectroscopia de Luz Próxima ao Infravermelho , Neoplasias Uterinas/metabolismo , Neoplasias Uterinas/cirurgia
2.
Rheumatol Int ; 35(2): 265-72, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25187198

RESUMO

The aim of this study was to validate a novel technique that predicts stopping of disease-modifying anti-rheumatic drugs (DMARDs) and biologic agents (BA) from the Veterans Affairs (VA) database and compare infection risks of rheumatoid arthritis patients who stopped versus continued DMARDs/BA perioperatively. We identified 6,024 patients on 1 DMARD or BA in the perioperative period between 1999 and 2009. Time gap between medication stop date and the next start date predicted drug stoppage (X). Time gap between surgery date and stop date predicted whether stoppage was before surgery (Y). Chart review from Houston VA was used for validation. ROC analyses were performed on chart review data to obtain X and Y cutoffs. The primary endpoints were wound infections and other infections within 30 days. ROC analyses found X ≥ 33 (AUC = 0.954) and Y ≥ -11 (AUC = 0.846). Risk of postoperative infections was not different when stopping and continuing DMARDs/BA preoperatively. Stopping BA after surgery was associated with higher odds of postoperative wound (OR 14.15, 95 % CI 1.76-113.76) and general infection (OR 9.2, 95 % CI 1.99-42.60) compared to not stopping. Stopping DMARDs after surgery was associated with increased risk of postoperative general infection (OR 1.84, 95 % CI 1.07-3.16) compared with not stopping. There was positive association between stopping DMARDs after surgery and postoperative wound infection but failed to achieve statistical significance (OR 1.67, 95 % CI 0.96-2.91). There was no significant difference in postoperative infection risk when stopping or continuing DMARD/BA. Our new validated method can be utilized in the VA and other databases to predict drug stoppage.


Assuntos
Antirreumáticos/uso terapêutico , Artrite Reumatoide/tratamento farmacológico , Fatores Biológicos/uso terapêutico , Período Perioperatório , Procedimentos Cirúrgicos Operatórios , Infecção da Ferida Cirúrgica/epidemiologia , Adulto , Estudos de Coortes , Bases de Dados Factuais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Curva ROC , Fatores de Risco , Fator de Necrose Tumoral alfa/antagonistas & inibidores , Estados Unidos , United States Department of Veterans Affairs
3.
Gynecol Endocrinol ; 30(12): 899-901, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25111756

RESUMO

The aim of this study is to evaluate the response rate to natural progesterone in non-atypical endometrial hyperplasia and to identify the lowest effective dose. A total of 197 patients of childbearing age with simple or complex hyperplasia were retrospectively identified. The women were treated with a cyclic administration of progesterone at different dosages (100 versus 200 versus 300 mg daily). Endometrial biopsies were performed at 6, 12, 18 months. In comparing progesterone to a regimen of no therapy, a significantly higher remission rate was observed in the progesterone group than in the latter (95 versus 75%, p = 0.05 for simple hyperplasia; 89 versus 35%, p < 0.001 for complex hyperplasia). Out of 60 women with simple hyperplasia, remission was observed in 9/11 (81.8%), 40/41 (97.5%) and 8/8 (100%) patients treated, respectively, with progesterone 100, 200 and 300 mg daily. Out of 72 women with complex hyperplasia, remission was observed in 3/5 (60%), 49/53 (92.4%) and 12/14 (85.7%) patients treated with progesterone 100, 200 and 300 mg daily, respectively. There was no statistically significant difference in the response rate in the two groups, neither with simple nor with complex hyperplasia. In conclusion, progesterone increased the regression rate of both simple and complex hyperplasia.


Assuntos
Hiperplasia Endometrial/tratamento farmacológico , Endométrio/efeitos dos fármacos , Progesterona/uso terapêutico , Progestinas/uso terapêutico , Adulto , Relação Dose-Resposta a Droga , Esquema de Medicação , Hiperplasia Endometrial/patologia , Endométrio/patologia , Feminino , Humanos , Pessoa de Meia-Idade , Progesterona/administração & dosagem , Progestinas/administração & dosagem , Indução de Remissão/métodos , Estudos Retrospectivos , Resultado do Tratamento , Adulto Jovem
4.
J Craniofac Surg ; 24(2): 675-8, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-23524776

RESUMO

BACKGROUND: This case report assesses the effectiveness of surgery plus pirfenidone (PFD) as a concomitant therapy in the management of facial trauma after severe dog bite. METHODS: A 16-month-old female patient who suffered a severe attack by a big-sized dog (Rottweiler) in the midface area was managed with surgery/PFD combination and followed up for 20 months to evaluate the efficacy to control, prevent, and improve injury sequels. RESULTS: Surgery/PFD combination offered a good complementary therapy downregulating inflammatory activity, improving blood supply, and activating cytokine modulation and collagen synthesis/biosynthesis (scar control). No side effects were reported in this case report. CONCLUSIONS: Surgery/PFD management for severe facial dog bites represents a safe and effective therapeutic option to protect and improve a patient's quality of life, minimizing long-time sequels.


Assuntos
Anti-Inflamatórios não Esteroides/uso terapêutico , Mordeduras e Picadas/tratamento farmacológico , Mordeduras e Picadas/cirurgia , Traumatismos Faciais/tratamento farmacológico , Traumatismos Faciais/cirurgia , Piridonas/uso terapêutico , Animais , Cães , Feminino , Humanos
5.
Rev Invest Clin ; 64(6 Pt 2): 625-33, 2012.
Artigo em Espanhol | MEDLINE | ID: mdl-23593781

RESUMO

OBJECTIVES: To study perinatal anxiety symptoms in a sample of Mexican mothers. A) To evaluate the effect of certain psychosocial factors during pregnancy on anxiety symptoms at two postpartum time intervals; and B) to determine whether this symptomatology is related to symptoms of postnatal depression. MATERIAL AND METHODS: In this secondary data analysis, 156 women were interviewed during pregnancy (T1): 149 were interviewed again at 6 weeks postpartum (T2) and 156 at 4-6 months postpartum (T3). Subjects were selected from women seeking prenatal attention at three health centers in Mexico City who presented with depressive symptomatology and/or previous history of depression. Two models were subjected to multivariate regression analysis to determine the influence of psychosocial factors in pregnancy (age, education, partner status, social support [APGAR], stress events, self-esteem [Coopersmith], depressive symptomatology [BDI-II], and anxiety [SCL-90]) on anxiety symptomatology (SCL-90) in T2 and T3. Two additional linear regression analyses were performed to evaluate the influence of prenatal anxiety symptomatology (SCL-90) on postpartum depression symptoms (BDI-II), one for each postnatal period (T2, T3). RESULTS: The variables that predicted postpartum anxiety symptomatology in T2 were anxiety symptoms and lack of social support; in T3 they were anxiety symptoms, lack of a partner, and lack of social support. Prenatal anxiety symptoms predicted postpartum depressive symptomatology at both postpartum intervals (T2, T3). CONCLUSIONS: Untreated prenatal anxiety symptomatology is predictive of symptoms of anxiety and depression in the postpartum period, suggesting the need for timely detection and treatment. Women lacking social support or partners are a population particularly vulnerable to anxiety symptoms, and merit interventions that address these issues.


Assuntos
Ansiedade/psicologia , Depressão Pós-Parto/psicologia , Complicações na Gravidez/psicologia , Psicologia , Transtornos Puerperais/psicologia , Adolescente , Adulto , Ansiedade/epidemiologia , Comorbidade , Depressão Pós-Parto/epidemiologia , Transtorno Depressivo/epidemiologia , Diagnóstico Precoce , Feminino , Humanos , Entrevista Psicológica , Casamento , Idade Materna , México/epidemiologia , Análise Multivariada , Gravidez , Complicações na Gravidez/epidemiologia , Transtornos Puerperais/epidemiologia , Autoimagem , Índice de Gravidade de Doença , Apoio Social , Estresse Psicológico/epidemiologia , Fatores de Tempo , Adulto Jovem
6.
Chemosphere ; 221: 219-225, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30640004

RESUMO

Geobacter sulfurreducens and anthraquinone-2-sulfonate (AQS) were used suspended and immobilized in barium alginate during the biotransformation of 4-nitrophenol (4-NP). The assays were conducted at different concentrations of 4-NP (50-400 mg/L) and AQS, either in suspended (0-400 µM) or immobilized form (0 or 760 µM), and under different pH values (5-9). G. sulfurreducens showed low capacity to reduce 4-NP in absence of AQS, especially at the highest concentrations of the contaminant. AQS improved the reduction rates from 0.0086 h-1, without AQS, to 0.149 h-1 at 400 µM AQS, which represent an increment of 17.3-fold. The co-immobilization of AQS and G. sulfurreducens in barium alginate beads (AQSi-Gi) increased the reduction rates up to 4.8- and 7.2-fold, compared to incubations with G. sulfurreducens in suspended and immobilized form, but in absence of AQS. AQSi-Gi provides to G. sulfurreducens a barrier against the possibly inhibiting effects of 4-NP.


Assuntos
Alginatos/química , Antraquinonas/química , Biotransformação , Geobacter/metabolismo , Nitrofenóis/química , Concentração de Íons de Hidrogênio , Oxirredução
8.
J Obes ; 2017: 2085136, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28744374

RESUMO

Several studies suggest that the holiday season, starting from the last week of November to the first or second week of January, could be critical to gaining weight. This study aims to review the literature to determine the effects of the holidays on body weight. In studies of adults, a significant weight gain was consistently observed during this period (0.4 to 0.9 kg, p < 0.05). The only study in college students found an effect on body fat but not on weight (0.1 kg, p = 0.71). The only study found in children did not show an effect on BMI percentile (-0.4%, p > 0.05) during this period. Among individuals with obesity who attempt to lose weight, an increase in weight was observed (0.3 to 0.9 kg, significant in some but not in all studies), as well as increase in weight in motivated self-monitoring people (0.4 to 0.6%, p < 0.001). Programs focused on self-monitoring during the holidays (phone calls and daily mailing) appeared to prevent weight gain, but information is limited. The holiday season seems to increase body weight in adults, even in participants seeking to lose weight and in motivated self-monitoring people, whereas in children, adolescents, and college students, very few studies were found to make accurate conclusions.


Assuntos
Obesidade/prevenção & controle , Aumento de Peso , Adulto , Fatores Etários , Criança , Férias e Feriados , Humanos , Narração
9.
Cancer Epidemiol Biomarkers Prev ; 15(10): 1914-9, 2006 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-17035399

RESUMO

PURPOSE: To evaluate study feasibility, toxicity, drug concentrations, and activity of escalating doses of the synthetic retinoid fenretinide [N-(4-hydroxyphenyl)retinamide (4-HPR)] in ovarian cancer by measuring serum CA125 and cytomorphometric biomarkers in cancer cells collected from ascitic fluid before and after treatment. METHODS: Twenty-two naive patients with ascitic ovarian cancer were treated with escalating doses of 4-HPR at 0, 400, 600, and 800 mg/d for 1 to 4 weeks before surgery. Changes in the proportion of proliferating cells expressed by Ki67 and computer-assisted cytomorphometric variables (nuclear area, DNA index, and chromatin texture) were determined in ascitic cells. Drug levels were measured by high-performance liquid chromatography. RESULTS: Doses up to 800 mg/d were well tolerated, and no adverse reactions occurred. There was no effect of 4-HPR on changes in serum CA125, Ki67 expression, which were assessed in 75% of subjects, and cytomorphometric variables, which were assessed in 80% of subjects. Plasma retinol levels were significantly lower in affected women than healthy donors. 4-HPR plasma concentrations increased slightly with increasing doses and attained a 1.4 micromol/L concentration with 800 mg/d. Drug levels in malignant ascitic cells and tumor tissue were higher than in plasma but were 50 and 5 times lower, respectively, than in carcinoma cells treated in vitro with 1 micromol/L 4-HPR. CONCLUSIONS: Cell biomarkers can be measured in ascitic cells to assess drug activity. Under our experimental conditions, 4-HPR did not show activity in advanced ovarian cancer cells. However, clinical evidence supports further investigation of fenretinide for ovarian cancer prevention.


Assuntos
Antineoplásicos/uso terapêutico , Líquido Ascítico/efeitos dos fármacos , Fenretinida/uso terapêutico , Neoplasias Epiteliais e Glandulares/tratamento farmacológico , Neoplasias Epiteliais e Glandulares/cirurgia , Neoplasias Ovarianas/tratamento farmacológico , Neoplasias Ovarianas/cirurgia , Ovariectomia , Adulto , Idoso , Antineoplásicos/administração & dosagem , Antineoplásicos/efeitos adversos , Antineoplásicos/metabolismo , Líquido Ascítico/química , Líquido Ascítico/citologia , Líquido Ascítico/metabolismo , Biomarcadores Tumorais/sangue , Antígeno Ca-125/sangue , Antígeno Ca-125/efeitos dos fármacos , Tumor Carcinoide/sangue , Tumor Carcinoide/tratamento farmacológico , Tumor Carcinoide/patologia , Tumor Carcinoide/cirurgia , Estudos de Casos e Controles , Proliferação de Células/efeitos dos fármacos , Cromatografia Líquida de Alta Pressão , Relação Dose-Resposta a Droga , Estudos de Viabilidade , Feminino , Fenretinida/administração & dosagem , Fenretinida/efeitos adversos , Fenretinida/metabolismo , Fibrossarcoma/sangue , Fibrossarcoma/tratamento farmacológico , Fibrossarcoma/patologia , Fibrossarcoma/cirurgia , Humanos , Antígeno Ki-67/sangue , Antígeno Ki-67/efeitos dos fármacos , Modelos Lineares , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Neoplasias Epiteliais e Glandulares/sangue , Neoplasias Epiteliais e Glandulares/patologia , Neoplasias Ovarianas/sangue , Neoplasias Ovarianas/patologia , Resultado do Tratamento , Vitamina A/sangue
10.
J Reprod Med ; 49(8): 585-8, 2004 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-15457847

RESUMO

OBJECTIVE: To analyze 15 consecutive cases of placental site trophoblastic tumor seen in a single reference institution for gestational trophoblastic disease, San Gerardo Hospital, Monza, Italy. STUDY DESIGN: Consecutive patients affected by placental site trophoblastic tumors were selected from our computerized database. RESULTS: There were 15 patients with placental site trophoblastic tumor, with a median age of 35 years. The antecedent pregnancy was a term one in 6 cases (40%), a miscarriage in 4 cases (27%), a termination in 2 cases (13%) and a molar abortion in 2 cases (13%). In 1 case the previous pregnancy was unrecognized. The median interval from the last pregnancy was 12 months, and the presenting symptom in 11 cases was vaginal bleeding, in 2 cases amenorrhea, in 1case a nephrotic syndrome and in 1 case, presenting with metastatic disease, hemoptysis. Six patients were treated using neoadjuvant chemotherapy with etoposide/methotrexate/actinomycin-etoposide/ vincristine (EMA-CO) followed in 5 of 6 (83%) cases by hysterectomy. One patient had only medical treatment with EMA-CO because of a strong desire for or childbearing and had a complete response; after 15 months she was free from disease. The last 9 patients underwent surgery as the first therapy. Among these patients 1 had presented with metastatic pulmonary disease and underwent chemotherapy, with complete disappearance of the pulmonary lesions. Two of these 9 patients had a relapse; the mirst patient had a pelvic and bladder relapse, and 14 months after multiple chemotherapy and surgery, she died. The second had a suburethral relapse 2 months after initial surgery; after chemotherapy and surgery she was well and free of disease. CONCLUSION: Our experience suggests that the role of chemotherapy may be reconsidered not only for metastatic disease but als of or uterine disease when choosing conservative management in young, fertile patients who desire childbearing. Chemotherapy may play an important role in avoiding relapse or early metastases even in patients who underwent hysterectomy as primary treatment.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Recidiva Local de Neoplasia , Doenças Placentárias/tratamento farmacológico , Doenças Placentárias/patologia , Neoplasias Trofoblásticas/tratamento farmacológico , Neoplasias Trofoblásticas/patologia , Neoplasias Uterinas/tratamento farmacológico , Neoplasias Uterinas/patologia , Adulto , Fatores Etários , Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Ciclofosfamida/administração & dosagem , Dactinomicina/administração & dosagem , Etoposídeo/administração & dosagem , Feminino , Fertilidade , Humanos , Metotrexato/administração & dosagem , Metástase Neoplásica , Gravidez , Estudos Retrospectivos , Resultado do Tratamento , Vincristina/administração & dosagem
11.
PLoS One ; 7(8): e43257, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22916233

RESUMO

BACKGROUND: There is little data on treatment of Langerhans cell histiocytosis (LCH) in adults. Available data is on small numbers of patients with short follow-up times and no comparison of results from different treatment regimens. We analyzed the responses of adult LCH patients with bone lesions to three primary chemotherapy treatments to define the optimal one. METHODS AND FINDINGS: Fifty-eight adult patients with bone lesions, either as a solitary site or as a component of multisystem disease, were analyzed for disease location and response to surgery, curettage, steroids, radiation, vinblastine/prednisone, 2-Chlorodeoxyadenosine (2-CdA), or cytosine arabinoside (ARA-C). The mean age of patients was 32 years, with equal gender distribution. Twenty-nine patients had 1 lesion; 16, 2 lesions; 5, 3 lesions; and 8 had 4 or more. Most bone lesions were in the skull, spine, or jaw. Chemotherapy, surgery, curettage, or radiation, but not steroids alone, achieved improvement or resolution of lesions in a majority of patients. Comparison of the three chemotherapy regimens revealed 84% of patients treated with vinblastine/prednisone either did not respond or relapsed within a year, whereas 59% of patients treated with 2-CdA and 21% treated with ARA-C failed. Toxicity was worse with the vinblastine/prednisone group as 75% had grade 3-4 neuropathy. Grade 3-4 cytopenias occurred in 37% of the 2-CdA -treated patients and 20% of the ARA-C-treated patients. The major limitation of this study is it is retrospective and not a clinical trial. CONCLUSIONS: ARA-C is an effective and minimally toxic treatment for LCH bone lesions in adults. In contrast, vinblastine/prednisone results in poor overall responses and excessive toxicity.


Assuntos
Doenças Ósseas/tratamento farmacológico , Histiocitose de Células de Langerhans/tratamento farmacológico , Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prednisona/uso terapêutico , Estudos Retrospectivos , Resultado do Tratamento , Vimblastina/uso terapêutico , Adulto Jovem
12.
Oncology ; 64(4): 370-3, 2003.
Artigo em Inglês | MEDLINE | ID: mdl-12759534

RESUMO

Sertoli-Leydig cell tumors (SLCTs) are rare neoplasms, accounting for less than 0.2% of ovarian tumors. The endometrioid-like variant of yolk sac tumor (YST) is very rare, and the most extensive series reported only 8 cases. We present a case of ovarian SLCT with endometrioid-like YST in a patient with a 46,XX karyotype with Y-chromosomal material. A 26-year-old woman had undergone a right salpingo-oophorectomy for SLCT with endometrioid-like YST. Chromosomal analysis revealed a 46,XX karyotype with Y-chromosomal material insertion into chromosome 1. The patient's father and sister, and 7 other paternal relatives (4 male and 3 female) presented the same chromosome variant without evidence of cancer. The YST component relapsed to the right side of the uterine wall and then metastasized to the peritoneum and liver, while SLCT was eradicated with primary surgery. Several chemotherapeutic regimens were totally ineffective to control tumor progression. She died of disease progression 54 months after the diagnosis. We adopted the policy of a close surveillance for ovarian neoplasms for the 22-year-old sister of the patient, who presented the same Y-chromosomal material in her karyotype. In very rare tumors, new methods, based on molecular and cytogenetic models, are requested to define recommended management.


Assuntos
Cromossomos Humanos Y , Tumor do Seio Endodérmico , Neoplasias Ovarianas , Tumor de Células de Sertoli-Leydig , Adulto , Tumor do Seio Endodérmico/genética , Tumor do Seio Endodérmico/patologia , Feminino , Humanos , Neoplasias Ovarianas/genética , Neoplasias Ovarianas/patologia , Linhagem , Tumor de Células de Sertoli-Leydig/genética , Tumor de Células de Sertoli-Leydig/patologia
13.
Monterrey, Nuevo León; s.n; 2002. 22 p. 28 cm.
Tese em Espanhol | Repositorio | ID: rpo-2276

RESUMO

Propósito y método del estudio: El propósito fue determinar la prevalencia de causas de hospitalización de personas adultas con diabetes mellitus tipo 2 y sus características, en un hospital de segundo nivel de atención. El diseño del estudio fue de tipo epidemiológico, aplicado en la modalidad de encuesta transversal. La población de estudio se conformó de expedientes clínicos de pacientes adultos hospitalizados por diabetes mellitus tipo 2 en una unidad de 2o nivel de seguridad social de la ciudad de Guadalupe, N.L. Contribuciones y conclusiones: Los resultados corresponden a 90 pacientes adultos hospitalizados tomados de los expedientes, 57% del sexo masculino y 43% del femenino, con edad media de 60.72 años (DE = 11.34; 40-91); promedio de educación formal de 4.57 años (DE = 3.46; 0-15) y promedio de años diagnóstico de la diabetes de 17.30 años (DE =7.39; 1-35). Dentro de los resultados de estimación de prevalencia por causa de hospitalización del adulto con diabetes mellitus tipo 2, se encontró que el pie diabético es la primer causa de hospitalización con un 46% de prevalencia, se presenta más en el sexo masculino, en menores de 65 años de edad; con menos de seis años de escolaridad y más de diez años diagnóstico. Se realizó un análisis adicional aplicándose el estadístico de estimación de razón de prevalencia, en el cual se identificó asociación significativa entre pie diabético y sexo masculino, donde se pudo observar que por cada mujer, se hospitalizan tres hombres (Odds Ratio de 3.63). Los estudios epidemiológicos sobre prevalencia de complicaciones que llevan a hospitalización, son valiosos: para valorar el nivel de complicaciones del grupo de pacientes con diabetes mellitus y evaluarlo en el contexto de los patrones que reportan la literatura sobre tales estados. Se recomienda llevar a cabo estos estudios en unidades de segundo y tercer nivel para así comparar las causas de hospitalización, así como variables clínicas y demográficas que se asocian con la evolución del padecimiento."(AU)


Assuntos
Adulto , Diabetes Mellitus Tipo 2/complicaciones , Diabetes Mellitus Tipo 2/prevención & control , Hospitalización/tendencias , Complicaciones de la Diabetes/prevención & control
14.
San Nicolás de los Garza, Nuevo León; s.n; 2000. vii,77 p. 28 cm.
Tese em Espanhol | Repositorio | ID: rpo-2236

RESUMO

"Área de Estudio: Fisiología Bacteriana. Propósito y Método de Estudio: Estudiar el efecto de la presencia de los iones Cu (II) y Zn (II) sobre la actividad respiratoria del Lactobacillus casei ATCC 393, caracterizada por la producción de CO2, utilizando el método directo de Warburg. En el presente trabajo se realizaron tres series de experimentos; en la primera, se midió la producción de C02 en ausencia de los iones estudiados, mientras que en las otras dos, se estudió el efecto individual de cada uno de los iones, a concentraciones de 50, 500 y 5000 (i M, en el caldo de cultivo. El efecto se cuantificó midiendo las diferencias en las variables estadísticas, y los parámetros cinéticos de un modelo exponencial, que caracterizaron la producción de CO2 en ausencia y en presencia de los iones estudiados. Contribuciones y Conclusiones: Se encontró que la presencia de los iones Cu (II) y Zn (II) modifican tanto la cantidad como la velocidad de producción de C02l de las observadas en ausencia de éstos. La presencia de los iones Cu(ll) y Zn (II) incrementan la producción de C02 hasta un 67.3 y 155.7 % respectivamente. Las velocidades de producción durante el período de estudio son generalmente superiores a las medidas en condiciones normales, sin embargo, para las concentraciones de Cu (II) 5000 M y Zn (II) 500 M son inferiores en un 37.37 y 12.05% respectivamente."(AU)


Assuntos
Lactobacillus casei/química , Lactobacillus casei/crecimiento & desarrollo , Dióxido de Carbono/síntesis química , Bacterias/química
16.
Salud ment ; 9(1): 27-31, mar. 1986. tab
Artigo em Espanhol | LILACS | ID: lil-33238

RESUMO

Se aplicaron una versión en español del Inventario de Roles Sexuales de Bem (IRSB) y cuatro Escalas Nuevas de Roles Sexuales, diseñados en México, a 42 hombres y a 40 mujeres, trabajadores de varias empresas. En la escala de Masculinidad del IRSB, los hombres obtuvieron puntajes significativamente mayores que las mujeres. No se encontraron diferencias significativas entre los sexos en las escalas de Femineidad y de Deseabilidad Social. Por otra parte, en las Escalas Nuevas no se encontraron diferencias significativas en las escalas Positivas Masculina y Femenina. En las escalas Negativas, Masculina y Femenina las mujeres obtuvieron puntajes significativamente más altos. Se llevaron a cabo comparaciones adicionales en relación a la edad, al estado civil y a la escolaridad. También se compararon estos resultados con los de un estudio anterior en estudiantes mexicanos. En términos generales, los resultados sugieren que los obreros se describen con más rasgos instrumentales, tales como ser seguros de sí mismos, confiados, independientes, etc., que las mujeres; las mujeres se describen con más características masculinas y femeninas indeseables, tales como ser sumisas, abnegadas, rudas y vanidosas, que los hombres; y ambos sexos se describen en forma similar en cuanto a aspectos positivos Masculinos y Femeninos y de Deseabilidad Social, como ser maduros, intuitivos, trabajadores, sensibles, tiernos, compasivos, amigables, etc


Assuntos
Humanos , Masculino , Feminino , Identidade de Gênero , México
17.
Salud ment ; 11(3): 25-9, sept. 1988. tab
Artigo em Espanhol | LILACS | ID: lil-66332

RESUMO

El objetivo del presente estudio fue obtener datos normativos e información sobre la validez de la Escala de Deseabilidad Social de Marlowe y Crowne. Los sujetos fueron 478 estudiantes universitarios: 214 hombres y 264 mujeres, de 18 a 22 años de edad. Los resultados dieron una media para el grupo, de 19.76 con una desviación estándar de 5.17; no se observaron diferencias significativas entre los sexos; se obtuvieron los puntales "Z". Se observó que la curva de frecuencia fue muy similar a la normal y que el 63% de los casos obtuvo calificaciones alrededor de la media. Los resultados de un análisis factorial (con componentes principales y rotación oblicual) mostraron que tres factores pudieron ser explicados, los cuales acumularon el 23.6% de la varianza. Se encontró que los reactivos de cad factor fueron muy heterogeneos como para darles una explicación conceptual distinta de la de "deseabilidad social". Finalmente, un análisis del poder de discriminación de cada reactivo de "alta" y "baja" deseabilidad social, demostró que 32 de los 33 reactivos pudieron discriminar eficazmente (p <-.05> a los dos grupos. Como conclusión, se plantea que los resultados de este estudio apoyan, en términos generales, la validez de constructo de la escala y proveen datos normativos útiles sobre ella


Assuntos
Humanos , Personalidade , Inventário de Personalidade , MMPI , Identificação Social
18.
Salud ment ; 12(3): 14-20, sept. 1989. tab
Artigo em Espanhol | LILACS | ID: lil-89525

RESUMO

Los objetivos de este estudio fueron, primero, obtener la validez de constructo y la confiabilidad del Cuestionario de la Personalidad de Eysenck (CPE) en una población de adultos mexicanos; segundo, comparar los resultados obtenidos en México con los de Inglaterra y, tercer, obtener una versión valida para México del CPE. Una muestra de 474 hombres y 514 mujeres mexicanos, de 36.99 ñ 15.45 y 38.14 ñ 15.23 años, respectivamente, completaron el instrumento traducido al español. Las comparaciones de los factores, usando el procedimiento de componentes principales y extrayendo los primeros cuatro factores, de Psicoticismo (P), Extraversión (E), neuroticismo (N) y Deseabilidad Social o "Mentiras" (L) mostraron un gran similitud entre México e Inglaterra, siendo los valores de 0.91 a 0.97. La introducción de algunos cambios en la calificación de las escalas para México produjo coeficientes de confiabilidad bastante aceptables en el rango de 0.68 a 0.87, al mismo tiempo que mostró que las diferencias entre los sexos fueron en al dirección usual, según lo reportado en otros países; por ejemplo, los hombres obtuvieron calificaciones mayores que las mujeres en P pero menores en N y L. Por otra parte, las correlaciones entre las escalas mostraron valores razonablemente bajos. Las comparaciones entre los paises, usando únicamente los reactivos que tanto las escalas mexicanas como las inglesas tuvieron en común, mostraron que los sujetos mexicanos obtuvieron puntuaciones mayores en E y L, y sólo un poco más altas en P, que su contraparte inglesa; y más bajas en N, únicamente en las mujeres. Los resultados sugieren que el CEP puede ser utilizado en México con la guía de calificación apropiada. El presente trabajo tambíen demuestra la necesidad de investigar cada reactivo en cada país en el que se quiera usar una prueba, antes de adoptar instrumentos estandarizados ene l extranjero


Assuntos
Adolescente , Adulto , Pessoa de Meia-Idade , Humanos , Masculino , Feminino , Personalidade , Comparação Transcultural
19.
Acta psiquiátr. psicol. Am. Lat ; 35(1/2): 39-47, ene.-jun. 1989. tab
Artigo em Espanhol | LILACS | ID: lil-80491

RESUMO

Se ampliaron una revisión en español del Inventario de Roles Sexuales de BEM (IRSB) y cuatro Escalas de Roles Sexuales, diseñadas en México, a 42 hombres y 40 mujeres, trabajadores de varias empresas. Los datos de cada inventario fueron sometidos a análisis factoriales independientes. Cuatro factores interpretables se obtuvieron del IRSB y tres de las Escalas Nuevas. Estos resultados aployan considerablemente la validez de constructo de ambos instrumentos. Se comparan los resultados con los obtenidos en otros estudios mexicanos y extranjeros, y se discuten las diferencias y similitudes en cuanto a los conceptos de masculinidad y de feminidad de los grupos


Assuntos
Humanos , Masculino , Feminino , Status Social , Identidade de Gênero , Inventário de Personalidade , Escalas de Graduação Psiquiátrica , Comércio , Indústrias , México
20.
Acta psiquiátr. psicol. Am. Lat ; 35(1/2): 39-47, ene.-jun. 1989. Tab
Artigo em Espanhol | BINACIS | ID: bin-28229

RESUMO

Se ampliaron una revisión en español del Inventario de Roles Sexuales de BEM (IRSB) y cuatro Escalas de Roles Sexuales, diseñadas en México, a 42 hombres y 40 mujeres, trabajadores de varias empresas. Los datos de cada inventario fueron sometidos a análisis factoriales independientes. Cuatro factores interpretables se obtuvieron del IRSB y tres de las Escalas Nuevas. Estos resultados aployan considerablemente la validez de constructo de ambos instrumentos. Se comparan los resultados con los obtenidos en otros estudios mexicanos y extranjeros, y se discuten las diferencias y similitudes en cuanto a los conceptos de masculinidad y de feminidad de los grupos (AU)


Assuntos
Humanos , Masculino , Feminino , Identidade de Gênero , Inventário de Personalidade , Escalas de Graduação Psiquiátrica , Status Social , Indústrias , Comércio , México
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