Detalhe da pesquisa
1.
Treatment with THI, an inhibitor of sphingosine-1-phosphate lyase, modulates glycosphingolipid metabolism and results therapeutically effective in experimental models of Huntington's disease.
Mol Ther
; 31(1): 282-299, 2023 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36116006
2.
Treatment with the Glycosphingolipid Modulator THI Rescues Myelin Integrity in the Striatum of R6/2 HD Mice.
Int J Mol Sci
; 24(6)2023 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36983032
3.
Polysialic Acid Sustains the Hypoxia-Induced Migration and Undifferentiated State of Human Glioblastoma Cells.
Int J Mol Sci
; 23(17)2022 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36076963
4.
Differential Expression of Sphingolipid Metabolizing Enzymes in Spontaneously Hypertensive Rats: A Possible Substrate for Susceptibility to Brain and Kidney Damage.
Int J Mol Sci
; 22(7)2021 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33917593
5.
Stimulation of S1PR5 with A-971432, a selective agonist, preserves blood-brain barrier integrity and exerts therapeutic effect in an animal model of Huntington's disease.
Hum Mol Genet
; 27(14): 2490-2501, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29688337
6.
Abnormal expression of sphingolipid-metabolizing enzymes in the heart of spontaneously hypertensive rat models.
Biochim Biophys Acta Mol Cell Biol Lipids
; 1869(1): 159411, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37949293
7.
Blood-Brain Barrier Integrity Is Perturbed in a Mecp2-Null Mouse Model of Rett Syndrome.
Biomolecules
; 13(4)2023 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37189354
8.
Genome-wide screening in pluripotent cells identifies Mtf1 as a suppressor of mutant huntingtin toxicity.
Nat Commun
; 14(1): 3962, 2023 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37407555
9.
Brain Region and Cell Compartment Dependent Regulation of Electron Transport System Components in Huntington's Disease Model Mice.
Brain Sci
; 11(10)2021 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34679332
10.
Stimulation of Sphingosine Kinase 1 (SPHK1) Is Beneficial in a Huntington's Disease Pre-clinical Model.
Front Mol Neurosci
; 12: 100, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31068790
11.
Assessment of Blood-brain Barrier Permeability by Intravenous Infusion of FITC-labeled Albumin in a Mouse Model of Neurodegenerative Disease.
J Vis Exp
; (129)2017 11 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29155766
12.
Vasorelaxing Action of the Kynurenine Metabolite, Xanthurenic Acid: The Missing Link in Endotoxin-Induced Hypotension?
Front Pharmacol
; 8: 214, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28507519
13.
Impairment of blood-brain barrier is an early event in R6/2 mouse model of Huntington Disease.
Sci Rep
; 7: 41316, 2017 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28117381
14.
Rac1 Pharmacological Inhibition Rescues Human Endothelial Dysfunction.
J Am Heart Assoc
; 6(3)2017 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28246076
15.
Morus alba extract modulates blood pressure homeostasis through eNOS signaling.
Mol Nutr Food Res
; 60(10): 2304-2311, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27234065