Inflammatory cytokines and functional impairment in drug-free subjects with mood disorder.

OBJECTIVE: To assess the association between peripheral levels of inflammatory cytokines and functional impairment in subjects with Bipolar Disorder (BD), Major Depressive Disorder (MDD) and population controls. METHODS: This was a cross-sectional study with a matched sample of drug-free young adults with BD (n=48), MDD (n=48) and population controls (n=48). Mood disorder was confirmed by a certified psychologist using the Structured Clinical Interview for DSM-IV (SCID-I). Functional impairment was assessed using the Functional Assessment Short Test (FAST). Serum levels of IL-6 and IL-10 were measured by ELISA. RESULTS: Peripheral levels of IL-6 and IL-10 were not significantly different between subjects with BD, MDD compared to controls. Higher levels of functional impairment were verified in subjects with BD and MDD compared to population controls (p≤0.001). In addition, IL-6 and IL-10 levels were positively correlated with functional impairment in subjects with BD (IL-6: r=0.349, p=0.016; and IL-10: r=0.351, p=0.016). CONCLUSION: Inflammatory dysregulation was associated with functional impairment among drug-free subjects with BD. This finding suggests that inflammatory dysregulation may be involved in the neuroprogression of BD.

[Suicide risk and health risk behavior among youth between the ages of 18 and 24 years: a descriptive study]. / Risco de suicídio e comportamentos de risco à saúde em jovens de 18 a 24 anos: um estudo descritivo.

The aim of this study was to assess suicide risk and risk behavior in young people. A cross-sectional study in the urban area of Pelotas, Rio Grande do Sul State, Brazil was performed using systematic sampling with young people between the ages of 18 to 24 years. We measured the risk of suicide (MINI), behavior (YRBSS), abuse/substance dependence (ASSIST) and socioeconomic status (ABEP). Data was analyzed using SPSS software. The sample consisted of 1,560 young people and the prevalence of suicide risk was 8.6%. Suicide risk was associated with: having suffered an accident that required a visit to the emergency room (p = 0.011), fighting (p = 0.016), carrying a weapon (p = 0.001) and carrying a firearm (p ≤ 0.001), substance abuse/dependence (p ≤ 0.001), not having used a condom during the last sexual relationship (p = 0.025), not having a steady partner (p ≤ 0.001) and having sex with five or more people (p = 0.018). Young people that present risk behavior also represent a suicide risk.

Risco de suicídio e comportamentos de risco à saúde em jovens de 18 a 24 anos: um estudo descritivo / /Suicide risk and health risk behavior among youth between the ages of 18 and 24 years: a descriptive study

O objetivo foi avaliar risco de suicídio e comportamentos de risco em jovens. Estudo transversal na zona urbana de Pelotas, Rio Grande do Sul, Brasil, realizado por amostragem sistemática. Foram incluídos jovens de 18 a 24 anos, com capacidade cognitiva e que assinaram termo de consentimento. Foram aferidos risco de suicídio (MINI); comportamentos de risco (YRBSS); abuso/dependência de substâncias (ASSIST); e nível socioeconômico (ABEP). Os dados foram analisados no programa SPSS. A amostra constituiu-se de 1560 jovens e a prevalência de risco de suicídio foi de 8,6 por cento. O risco de suicídio foi associado com: ter sofrido acidente com necessidade de ir ao pronto-socorro (p = 0,011), ter entrado em briga com agressão física (p = 0,016), ter carregado arma branca (p = 0,001) e arma de fogo (p < 0,001), ter abuso/dependência de substâncias (p < 0,001), não ter utilizado preservativo na última relação sexual (p = 0,025), não ter parceiro fixo (p < 0,001) e ter relação sexual com cinco ou mais pessoas (p = 0,018). Jovens com comportamentos de risco também demonstram indícios de risco de suicídio.(AU)

The aim of this study was to assess suicide risk and risk behavior in young people. A cross-sectional study in the urban area of Pelotas, Rio Grande do Sul State, Brazil was performed using systematic sampling with young people between the ages of 18 to 24 years. We measured the risk of suicide (MINI), behavior (YRBSS), abuse/substance dependence (ASSIST) and socioeconomic status (ABEP). Data was analyzed using SPSS software. The sample consisted of 1,560 young people and the prevalence of suicide risk was 8.6 percent. Suicide risk was associated with: having suffered an accident that required a visit to the emergency room (p = 0.011), fighting (p = 0.016), carrying a weapon (p = 0.001) and carrying a firearm (p < 0.001), substance abuse/dependence (p < 0.001), not having used a condom during the last sexual relationship (p = 0.025), not having a steady partner (p < 0.001) and having sex with five or more people (p = 0.018). Young people that present risk behavior also represent a suicide risk.(AU)

Risco de suicídio e comportamentos de risco à saúde em jovens de 18 a 24 anos: um estudo descritivo / Suicide risk and health risk behavior among youth between the ages of 18 and 24 years: a descriptive study

O objetivo foi avaliar risco de suicídio e comportamentos de risco em jovens. Estudo transversal na zona urbana de Pelotas, Rio Grande do Sul, Brasil, realizado por amostragem sistemática. Foram incluídos jovens de 18 a 24 anos, com capacidade cognitiva e que assinaram termo de consentimento. Foram aferidos risco de suicídio (MINI); comportamentos de risco (YRBSS); abuso/dependência de substâncias (ASSIST); e nível socioeconômico (ABEP). Os dados foram analisados no programa SPSS. A amostra constituiu-se de 1560 jovens e a prevalência de risco de suicídio foi de 8,6 por cento. O risco de suicídio foi associado com: ter sofrido acidente com necessidade de ir ao pronto-socorro (p = 0,011), ter entrado em briga com agressão física (p = 0,016), ter carregado arma branca (p = 0,001) e arma de fogo (p < 0,001), ter abuso/dependência de substâncias (p < 0,001), não ter utilizado preservativo na última relação sexual (p = 0,025), não ter parceiro fixo (p < 0,001) e ter relação sexual com cinco ou mais pessoas (p = 0,018). Jovens com comportamentos de risco também demonstram indícios de risco de suicídio.

The aim of this study was to assess suicide risk and risk behavior in young people. A cross-sectional study in the urban area of Pelotas, Rio Grande do Sul State, Brazil was performed using systematic sampling with young people between the ages of 18 to 24 years. We measured the risk of suicide (MINI), behavior (YRBSS), abuse/substance dependence (ASSIST) and socioeconomic status (ABEP). Data was analyzed using SPSS software. The sample consisted of 1,560 young people and the prevalence of suicide risk was 8.6 percent. Suicide risk was associated with: having suffered an accident that required a visit to the emergency room (p = 0.011), fighting (p = 0.016), carrying a weapon (p = 0.001) and carrying a firearm (p < 0.001), substance abuse/dependence (p < 0.001), not having used a condom during the last sexual relationship (p = 0.025), not having a steady partner (p < 0.001) and having sex with five or more people (p = 0.018). Young people that present risk behavior also represent a suicide risk.