Detalhe da pesquisa
1.
Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and ß2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD).
Bioorg Med Chem Lett
; 41: 127975, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33753262
2.
Evaluation of active neutrophil elastase in sputum of bronchiectasis and cystic fibrosis patients: A comparison among different techniques.
Pulm Pharmacol Ther
; 59: 101856, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31626976
3.
CHF6001 II: a novel phosphodiesterase 4 inhibitor, suitable for topical pulmonary administration--in vivo preclinical pharmacology profile defines a potent anti-inflammatory compound with a wide therapeutic window.
J Pharmacol Exp Ther
; 352(3): 568-78, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25576073
4.
CHF6001 I: a novel highly potent and selective phosphodiesterase 4 inhibitor with robust anti-inflammatory activity and suitable for topical pulmonary administration.
J Pharmacol Exp Ther
; 352(3): 559-67, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25576075
5.
Monitoring inflammation and airway remodeling by fluorescence molecular tomography in a chronic asthma model.
J Transl Med
; 13: 336, 2015 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26496719
6.
Autocrine activity of cysteinyl leukotrienes in human vascular endothelial cells: Signaling through the CysLT2 receptor.
Prostaglandins Other Lipid Mediat
; 120: 115-25, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25839425
7.
Enlightened Mannhemia haemolytica lung inflammation in bovinized mice.
Vet Res
; 45: 8, 2014 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24460618
8.
Receptor for advanced glycation end products contributes to postnatal pulmonary development and adult lung maintenance program in mice.
Am J Respir Cell Mol Biol
; 48(2): 164-71, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23144333
9.
Synthesis of cysteinyl leukotrienes in human endothelial cells: subcellular localization and autocrine signaling through the CysLT2 receptor.
FASEB J
; 25(10): 3519-28, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21753081
10.
Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and ß2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases.
J Med Chem
; 65(15): 10233-10250, 2022 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35901125
11.
Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer.
Thorax
; 66(6): 521-7, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21460372
12.
Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents.
FASEB J
; 24(12): 4904-16, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20720158
13.
Patients' perspectives on bronchiectasis: findings from a social media listening study.
ERJ Open Res
; 7(3)2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-34350285
14.
Evaluation of lung inflammation induced by intratracheal administration of LPS in mice: comparison between MRI and histology.
MAGMA
; 23(2): 93-101, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20386954
15.
Novel Pyrrolidine Derivatives of Budesonide as Long Acting Inhaled Corticosteroids for the Treatment of Pulmonary Inflammatory Diseases.
J Med Chem
; 61(11): 4757-4773, 2018 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29741897
16.
Discovery and Optimization of Thiazolidinyl and Pyrrolidinyl Derivatives as Inhaled PDE4 Inhibitors for Respiratory Diseases.
J Med Chem
; 60(24): 10026-10046, 2017 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29200281
17.
Cysteinyl-leukotrienes receptor activation in brain inflammatory reactions and cerebral edema formation: a role for transcellular biosynthesis of cysteinyl-leukotrienes.
FASEB J
; 18(7): 842-4, 2004 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15001558
18.
Azithromycin inhibits nuclear factor-κB activation during lung inflammation: an in vivo imaging study.
Pharmacol Res Perspect
; 2(5): e00058, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25505605
19.
Novel class of benzoic acid ester derivatives as potent PDE4 inhibitors for inhaled administration in the treatment of respiratory diseases.
J Med Chem
; 57(3): 793-816, 2014 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24400806
20.
Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation.
PLoS One
; 7(8): e42454, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22905134