Detalhe da pesquisa
1.
A chemical screen for modulators of mRNA translation identifies a distinct mechanism of toxicity for sphingosine kinase inhibitors.
PLoS Biol
; 19(5): e3001263, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34033645
2.
Evaluating the utility of brightfield image data for mechanism of action prediction.
PLoS Comput Biol
; 19(7): e1011323, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37490493
3.
A phenomics approach for antiviral drug discovery.
BMC Biol
; 19(1): 156, 2021 08 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34334126
4.
Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Nature
; 544(7651): 508, 2017 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28447629
5.
Artificial intelligence for high content imaging in drug discovery.
Curr Opin Struct Biol
; 87: 102842, 2024 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38797109
6.
From pixels to phenotypes: Integrating image-based profiling with cell health data as BioMorph features improves interpretability.
Mol Biol Cell
; 35(3): mr2, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38170589
7.
A Decade in a Systematic Review: The Evolution and Impact of Cell Painting.
ArXiv
; 2024 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38745696
8.
A Decade in a Systematic Review: The Evolution and Impact of Cell Painting.
bioRxiv
; 2024 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38766203
9.
The anti-leprosy drug clofazimine reduces polyQ toxicity through activation of PPARγ.
EBioMedicine
; 103: 105124, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38701619
10.
Corrigendum: Development of new approach methods for the identification and characterization of endocrine metabolic disruptors-a PARC project.
Front Toxicol
; 6: 1394396, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38590784
11.
Merging bioactivity predictions from cell morphology and chemical fingerprint models using similarity to training data.
J Cheminform
; 15(1): 56, 2023 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37268960
12.
Development of new approach methods for the identification and characterization of endocrine metabolic disruptors-a PARC project.
Front Toxicol
; 5: 1212509, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37456981
13.
Morphological profiling of environmental chemicals enables efficient and untargeted exploration of combination effects.
Sci Total Environ
; 832: 155058, 2022 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35390365
14.
Integrating cell morphology with gene expression and chemical structure to aid mitochondrial toxicity detection.
Commun Biol
; 5(1): 858, 2022 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35999457
15.
NOX4 regulates TGFß-induced proliferation and self-renewal in glioblastoma stem cells.
Mol Oncol
; 16(9): 1891-1912, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35203105
16.
An Open-Source Modular Framework for Automated Pipetting and Imaging Applications.
Adv Biol (Weinh)
; 6(4): e2101063, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34693668
17.
New regulators of the tetracycline-inducible gene expression system identified by chemical and genetic screens.
FEBS Open Bio
; 12(10): 1896-1908, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36062323
18.
Prolonged estrogen deprivation triggers a broad immunosuppressive phenotype in breast cancer cells.
Mol Oncol
; 16(1): 148-165, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34392603
19.
High content drug screening for Fanconi anemia therapeutics.
Orphanet J Rare Dis
; 15(1): 170, 2020 06 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32605631
20.
The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity.
Cell Death Differ
; 27(2): 773-789, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31285544