Detalhe da pesquisa
1.
Pharmacology and Rationale for Seralutinib in the Treatment of Pulmonary Arterial Hypertension.
Int J Mol Sci
; 24(16)2023 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37628831
2.
Inhaled seralutinib exhibits potent efficacy in models of pulmonary arterial hypertension.
Eur Respir J
; 60(6)2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35680144
3.
Sterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonists.
Nat Chem Biol
; 11(2): 141-7, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25558972
4.
Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity.
Cancer Cell
; 41(6): 1073-1090.e12, 2023 06 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37236195
5.
The role of PIM kinases in human and mouse CD4+ T cell activation and inflammatory bowel disease.
Cell Immunol
; 272(2): 200-13, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22078270
6.
Corrigendum: Sterol metabolism controls TH17 differentiation by generating endogenous RORγ agonists.
Nat Chem Biol
; 11(9): 741, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26284677
7.
Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ) Agonist for Use in Treating Cancer.
J Med Chem
; 64(18): 13410-13428, 2021 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34499493
8.
RORγ Agonists Enhance the Sustained Antitumor Activity through Intrinsic Tc17 Cytotoxicity and Tc1 Recruitment.
Cancer Immunol Res
; 7(7): 1054-1063, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31064778
9.
Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis.
J Pharmacol Exp Ther
; 324(2): 497-506, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18024786
10.
In Vitro Priming of Adoptively Transferred T Cells with a RORγ Agonist Confers Durable Memory and Stemness In Vivo.
Cancer Res
; 78(14): 3888-3898, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29769201
11.
PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis.
J Neuroimmunol
; 182(1-2): 124-34, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17182110
12.
Therapeutic opportunities in the B7/CD28 family of ligands and receptors.
Curr Opin Pharmacol
; 5(4): 424-30, 2005 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15935730
13.
Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity.
Cell Rep
; 17(12): 3206-3218, 2016 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28009290
14.
Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity.
Oncoimmunology
; 5(12): e1254854, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-28123897
15.
PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta.
FEBS Lett
; 574(1-3): 37-41, 2004 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-15358536
16.
Cytotoxic T-lymphocyte antigen-4 and programmed death-1 function as negative regulators of lymphocyte activation.
Immunol Res
; 28(1): 49-59, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12947224
17.
IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity.
Immunity
; 16(4): 559-69, 2002 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-11970879