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Ann Neurol ; 89(5): 1041-1045, 2021 05.
Artigo em Inglês | MEDLINE | ID: mdl-33547819

RESUMO

Patients with coronavirus disease 2019 (COVID-19) can present with distinct neurological manifestations. This study shows that inflammatory neurological diseases were associated with increased levels of interleukin (IL)-2, IL-4, IL-6, IL-10, IL-12, chemokine (C-X-C motif) ligand 8 (CXCL8), and CXCL10 in the cerebrospinal fluid. Conversely, encephalopathy was associated with high serum levels of IL-6, CXCL8, and active tumor growth factor ß1. Inflammatory syndromes of the central nervous system in COVID-19 can appear early, as a parainfectious process without significant systemic involvement, or without direct evidence of severe acute respiratory syndrome coronavirus 2 neuroinvasion. At the same time, encephalopathy is mainly influenced by peripheral events, including inflammatory cytokines. ANN NEUROL 2021;89:1041-1045.


Assuntos
COVID-19/sangue , COVID-19/líquido cefalorraquidiano , Mediadores da Inflamação/sangue , Mediadores da Inflamação/líquido cefalorraquidiano , Doenças do Sistema Nervoso/sangue , Doenças do Sistema Nervoso/líquido cefalorraquidiano , Biomarcadores/sangue , Biomarcadores/líquido cefalorraquidiano , COVID-19/epidemiologia , Citocinas/sangue , Citocinas/líquido cefalorraquidiano , Humanos , Doenças do Sistema Nervoso/epidemiologia
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