RESUMO
The clinicopathological features currently used in breast cancer prognosis often fail to characterize the clinical heterogeneity of the disease accurately. Our study is aimed to investigate the predictive value of DNA flow cytometry in breast cancer. Previously untreated breast carcinoma samples (584) were snap frozen for flow-cytometry. Tumors were classified into three DNA index (DI) categories: i) tumors showing a DI =0.96-1.15 (diploid and near-diploid); ii) tumors with a DI >or=1.16 (hyperdiploid, tetraploid, multiploid and/or those with more than one diploid population); and iii) tumors with a DI Assuntos
Neoplasias da Mama/genética
, Ploidias
, Adulto
, Idoso
, Idoso de 80 Anos ou mais
, Neoplasias da Mama/patologia
, Neoplasias da Mama/cirurgia
, DNA de Neoplasias/análise
, DNA de Neoplasias/genética
, Feminino
, Citometria de Fluxo/métodos
, Humanos
, Pessoa de Meia-Idade
, Prognóstico
, Fase S/genética
, Análise de Sobrevida