Detalhe da pesquisa
1.
New mechanistic and functional insights into DNA topoisomerases.
Annu Rev Biochem
; 82: 139-70, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23495937
2.
Biochemical characterization of the meiosis-essential yet evolutionarily divergent topoisomerase VIB-like protein MTOPVIB from Arabidopsis thaliana.
Nucleic Acids Res
; 52(8): 4541-4555, 2024 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38499490
3.
Mechanistic analysis of carbon-carbon bond formation by deoxypodophyllotoxin synthase.
Proc Natl Acad Sci U S A
; 119(1)2022 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34969844
4.
Sequential Phosphorylation of Hepatitis C Virus NS5A Protein Requires the ATP-Binding Domain of NS3 Helicase.
J Virol
; 96(7): e0010722, 2022 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35293767
5.
Epoxidation Catalyzed by the Nonheme Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, AsqJ: Mechanistic Elucidation of Oxygen Atom Transfer by a Ferryl Intermediate.
J Am Chem Soc
; 142(13): 6268-6284, 2020 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32131594
6.
Topoisomerases as anticancer targets.
Biochem J
; 475(2): 373-398, 2018 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29363591
7.
Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry.
Nucleic Acids Res
; 45(18): 10861-10871, 2017 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28977631
8.
Structural basis of antizyme-mediated regulation of polyamine homeostasis.
Proc Natl Acad Sci U S A
; 112(36): 11229-34, 2015 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26305948
9.
Insights into the Desaturation of Cyclopeptin and its C3 Epimer Catalyzed by a non-Heme Iron Enzyme: Structural Characterization and Mechanism Elucidation.
Angew Chem Int Ed Engl
; 57(7): 1831-1835, 2018 02 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29314482
10.
Structural basis of the mercury(II)-mediated conformational switching of the dual-function transcriptional regulator MerR.
Nucleic Acids Res
; 43(15): 7612-23, 2015 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-26150423
11.
The many blades of the ß-propeller proteins: conserved but versatile.
Trends Biochem Sci
; 36(10): 553-61, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21924917
12.
Structural characteristics of the nonallosteric human cytosolic malic enzyme.
Biochim Biophys Acta
; 1844(10): 1773-83, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24998673
13.
Investigations into the binding of jadomycin DS to human topoisomerase IIß by WaterLOGSY NMR spectroscopy.
Org Biomol Chem
; 13(41): 10324-7, 2015 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26309036
14.
On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs.
Nucleic Acids Res
; 41(22): 10630-40, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24038465
15.
Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry.
Nucleic Acids Res
; 45(18): 10920, 2017 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28977544
16.
Expression, purification, crystallization and preliminary X-ray analysis of ribitol-5-phosphate cytidylyltransferase from Bacillus subtilis.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 68(Pt 10): 1195-7, 2012 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23027746
17.
Expression, purification, crystallization and preliminary X-ray analysis of the RecQ helicase catalytic core from Deinococcus radiodurans.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 68(Pt 10): 1234-6, 2012 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23027755
18.
Twisting of the DNA-binding surface by a beta-strand-bearing proline modulates DNA gyrase activity.
Nucleic Acids Res
; 38(12): 4173-81, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20215433
19.
Harnessing the Substrate Promiscuity of Dioxygenase AsqJ and Developing Efficient Chemoenzymatic Synthesis for Quinolones.
ACS Catal
; 11(12): 7186-7192, 2021 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35721870
20.
Structure of Human Phosphodiesterase 5A1 Complexed with Avanafil Reveals Molecular Basis of Isoform Selectivity and Guidelines for Targeting α-Helix Backbone Oxygen by Halogen Bonding.
J Med Chem
; 63(15): 8485-8494, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32663396