Detalhe da pesquisa
1.
The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists.
Bioorg Med Chem Lett
; 26(19): 4781-4784, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27595421
2.
The SAR of brain penetration for a series of heteroaryl urea FAAH inhibitors.
Bioorg Med Chem Lett
; 26(13): 3109-3114, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27189675
3.
Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia.
J Pharmacol Exp Ther
; 354(3): 471-82, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26177655
4.
Antihistamines and itch.
Handb Exp Pharmacol
; 226: 257-90, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25861785
5.
Two TRPV1 receptor antagonists are effective in two different experimental models of migraine.
J Headache Pain
; 16: 57, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26109436
6.
1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase.
Bioorg Med Chem Lett
; 24(5): 1280-4, 2014 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24513048
7.
Heteroarylureas with spirocyclic diamine cores as inhibitors of fatty acid amide hydrolase.
Bioorg Med Chem Lett
; 24(3): 737-41, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24433863
8.
A Phase 1 First-in-Human Pharmacokinetic and Pharmacodynamic Study of JNJ-64264681, a Covalent Inhibitor of Bruton's Tyrosine Kinase.
Clin Pharmacol Drug Dev
; 12(6): 611-624, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37125450
9.
Heteroaryl urea inhibitors of fatty acid amide hydrolase: structure-mutagenicity relationships for arylamine metabolites.
Bioorg Med Chem Lett
; 22(24): 7357-62, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23141911
10.
Effects of the selective orexin-2 receptor antagonist JNJ-48816274 on sleep initiated in the circadian wake maintenance zone: a randomised trial.
Neuropsychopharmacology
; 47(3): 719-727, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34628482
11.
Discovery of a novel series of selective HCN1 blockers.
Bioorg Med Chem Lett
; 21(18): 5197-201, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21824780
12.
The effects of FAAH inhibition on the neural basis of anxiety-related processing in healthy male subjects: a randomized clinical trial.
Neuropsychopharmacology
; 46(5): 1011-1019, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33335310
13.
Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists.
Bioorg Med Chem Lett
; 20(23): 7137-41, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20947352
14.
1,2-diamino-ethane-substituted-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepines as TRPV1 antagonists with improved properties.
Bioorg Med Chem Lett
; 20(23): 7142-6, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20932750
15.
Selective inhibition of peripheral cathepsin S reverses tactile allodynia following peripheral nerve injury in mouse.
Eur J Pharmacol
; 880: 173171, 2020 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32437743
16.
Identification and synthesis of 2,7-diamino-thiazolo[5,4-d]pyrimidine derivatives as TRPV1 antagonists.
Bioorg Med Chem Lett
; 19(1): 40-6, 2009 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19038548
17.
Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase.
Anesth Analg
; 108(1): 316-29, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19095868
18.
Activation of TRPA1 by farnesyl thiosalicylic acid.
Mol Pharmacol
; 73(4): 1225-34, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18171730
19.
Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH).
Bioorg Med Chem Lett
; 18(6): 2109-13, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18289847
20.
Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain.
J Neurosci
; 25(12): 3126-31, 2005 Mar 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-15788769