Differentiation syndrome during ivosidenib treatment with immunohistochemistry showing isocitrate dehydrogenase R132H mutation.

We report a case of differentiation syndrome in a patient receiving the IDH1 inhibitor ivosidenib, with skin biopsy showing isocitrate dehydrogenase (IDH) R132H-mutated leukemia cutis. A 72-year-old man with IDH1-mutated acute myeloid leukemia (AML), status-post allogeneic cell transplantation, on ivosidenib for 6 months, was admitted for culture-negative neutropenic fever, pink and purpuric plaques and patches on the legs, abdomen and back, edema, hypotension, and shortness of breath. Skin biopsy revealed an infiltrate of atypical, immature, myeloperoxidase-positive mononuclear cells compatible with leukemia cutis or Sweet syndrome. Although dermal edema and interstitial neutrophilic infiltrate with karyorrhexis characteristic of Sweet syndrome were not seen, the atypical cells lacked expression of CD117 and CD34, which were expressed in the original leukemia. Additional immunohistochemical staining of suspected blasts was strongly positive for IDH1 R132H, suggesting a diagnosis of leukemia cutis. As the immunophenotype of blasts in skin infiltrates can significantly differ from the immunophenotype seen in blood and bone marrow, this case shows that mutation-specific antibodies such as anti-IDH1 R132H may be useful to help distinguish malignant from non-malignant infiltrates in the skin. Furthermore, differentiation syndrome may show histopathologic features of leukemia cutis on skin biopsy.

A Scoping Review of the Community Health Worker Model Used for Food Systems Interventions Within the United States.

OBJECTIVE: To document and analyze the food systems interventions delivered by community health workers (CHW) serving as educators within the United States (U.S.). DATA SOURCE: Ten databases (ie, Agricola, CAB Abstracts, CINAHL, ERIC, Proquest Social Science and Education, Proquest Theses and Dissertations, PubMed, Scopus, SocIndex, Web of Science) and gray-literature repositories were searched for publications between 2005-2020. STUDY INCLUSION AND EXCLUSION CRITERIA: English-language and U.S. studies included with CHW as educators or facilitators for food systems interventions. Food systems defined as processes of production, processing, distribution, marketing, access, preparation, consumption, and disposal of food products. Studies excluded for clinical settings; non-adult CHWs; CHWs with medical or public health credentials; and programming guides, reviews, and commentaries. DATA EXTRACTION: Variables included CHW and intervention description, priority population, food system processes, and targeted and unexpected outcomes. DATA SYNTHESIS: Data were analyzed by the lead investigator and described narratively. RESULTS: Of 43 records, CHWs educated for consumption (n = 38), preparation (n = 33), and food access (n = 22) to improve health of priority populations. Community health workers educated for the highest number of food system processes in garden-based interventions. Programs reached many underserved racial and socioeconomic populations. CONCLUSIONS: The CHW model has been used to educate in interventions for all food systems processes and reached many diverse underserved audiences. Future work must explore garden-based food systems education and CHWs as community change agents.

Coaching competency and satisfaction with the coach: a multi-level structural equation model.

The purpose of this initial predictive validity study was to determine the ability of measures derived from the Athletes' Perceptions of Coaching Competency Scale II - High School Teams (APCCS II-HST) to predict satisfaction with the head coach. Specification of the statistical model was informed by the mediational model of coach-athlete interactions. The technical quality of the satisfaction measure was evaluated before testing the predictive validity of the coaching competency measures. Data were collected from athletes of seven sports. Athlete observations (N = 748) were clustered within teams (G = 74). Multi-group confirmatory factor analyses (CFA) provided evidence for factorial invariance of a reduced version of the satisfaction measure by athlete gender. Multi-level CFA provided evidence of model-data consistency for a reduced version of the satisfaction measure. Multi-level structural equation modelling provided evidence for the ability of latent coaching competency to positively predict latent satisfaction at both the athlete level (technique competency and motivation competency) and the team level (coaching competency) and for close model-data fit. Implications of this study include: that the APCCS II-HST should be viewed as a replacement for the Coaching Competency Scale when the intended population is appropriate; a preliminary multi-level measurement model for satisfaction with one's coach that should be considered as a potential starting point in subsequent studies; and empirical support for a key relationship proposed in the mediational model of coach-athlete interactions.

Coaching efficacy and exploratory structural equation modeling: a substantive-methodological synergy.

The purpose of this article was to provide a substantive-methodological synergy of potential importance to future research in sport and exercise psychology. The substantive focus was to improve the measurement of coaching efficacy by developing a revised version of the coaching efficacy scale (CES) for head coaches (N = 557) of youth sport teams (CES II-YST). The methodological focus was exploratory structural equation modeling (ESEM), a methodology that integrates the advantages of exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) within the general structural equation model (SEM). The synergy was a demonstration of how ESEM (as compared with CFA) may be used, guided by content knowledge, to develop (or confirm) a measurement model for the CES II-YST. A single-group ESEM provided evidence for close model-data fit, while a single-group CFA fit significantly worse than the single-group ESEM and provided evidence for only approximate model-data fit. A multiple-group ESEM provided evidence for partial factorial invariance by coach's gender.

The role of sport as a social status determinant for children: thirty years later.

The purpose of this study was to examine the role of sport as a social status determinant among racially diverse children. Participants were 1,233 fourth- to seventh-grade children. Results indicated there were gender, grade, and racial differences for the selection of social status determinants. Boys placed more importance than girls on being good at sports and wealth. Girls placed more importance than boys on getting good grades and being attractive. Fourth- and fifth-grade students ranked getting good grades as most important, while sixth- and seventh-grade students ranked being attractive as most important. Non-Hispanic Caucasian students ranked being good at sports and being attractive as most important, while African American students ranked getting good grades and wealth as most important

Proposed modifications to the conceptual model of coaching efficacy and additional validity evidence for the Coaching Efficacy Scale II-High School Teams.

The purpose of this study was to determine whether theoretically relevant sources of coaching efficacy could predict the measures derived from the Coaching Efficacy Scale II-High School Teams (CES II-HST). Data were collected from head coaches of high school teams in the United States (N=799). The analytic framework was a multiple-group confirmatory factor analysis with ordered-categorical indicators and observed covariates. Applying this framework to the conceptual model of coaching efficacy (CMCE) resulted in a statistical model equivalent to a multiple-group multivariate regression with latent outcomes. Results provided evidence for the ability of measures derived from the CES II-HST to be predicted by theoretically relevant sources of coaching efficacy and suggested modifications to the CMCE.

Relationship between decision-making self-efficacy, task self-efficacy, and the performance of a sport skill.

The purpose of this study was to examine the relationships between decision-making self-efficacy and task self-efficacy and subsequent decision-making and task performance. Sixty undergraduate students (30 males, 30 females) participated in this study, which involved infield defensive plays in softball. The physical task required participants to throw a ball at a target. The decision-making task required participants to watch video scenes depicting different infield defensive situations and decide where to throw the ball in each situation. Both tasks used manipulated failure. Self-efficacy was assessed before performance. Strength of decision-making and task self-efficacy predicted physical performance, but not decision-making performance.

Fear of injury in gymnastics: self-efficacy and psychological strategies to keep on tumbling.

The aim of this study was to examine female gymnasts' fear of injury, their sources of self-efficacy and the psychological strategies used to overcome their fears. The participants were 10 female gymnasts aged 12 - 17 years. They had all taken part in competitive gymnastics and had experienced some type of injury during their careers. Individual interviews were conducted using a structured interview guide. Data were analysed using an inductive content analysis. The results indicated that gymnasts were most fearful of injuries because of the difficulty in returning from an injury and being unable to participate in practices and competitions while injured. Gymnasts described aspects of their past performance experience, such as success, consistency and communication with significant others, as important sources of self-efficacy. Some examples of psychological strategies used to overcome their fear of injury were mental preparation (e.g. imagery, relaxation), just "going for a skill" and the coaches' influence.