Detalhe da pesquisa
1.
A Pan-Cyclophilin Inhibitor, CRV431, Decreases Fibrosis and Tumor Development in Chronic Liver Disease Models.
J Pharmacol Exp Ther
; 371(2): 231-241, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31406003
2.
C5A Protects Macaques from Vaginal Simian-Human Immunodeficiency Virus Challenge.
Antimicrob Agents Chemother
; 60(1): 693-8, 2016 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26552985
3.
Alisporivir inhibition of hepatocyte cyclophilins reduces HBV replication and hepatitis B surface antigen production.
Gastroenterology
; 148(2): 403-14.e7, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25305505
4.
Cyclophilin and NS5A inhibitors, but not other anti-hepatitis C virus (HCV) agents, preclude HCV-mediated formation of double-membrane-vesicle viral factories.
Antimicrob Agents Chemother
; 59(5): 2496-507, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25666154
5.
The combination of alisporivir plus an NS5A inhibitor provides additive to synergistic anti-hepatitis C virus activity without detectable cross-resistance.
Antimicrob Agents Chemother
; 58(6): 3327-34, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24687498
6.
Correlation between NS5A dimerization and hepatitis C virus replication.
J Biol Chem
; 287(36): 30861-73, 2012 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-22801423
7.
HCV NS5A and IRF9 compete for CypA binding.
J Hepatol
; 58(1): 16-23, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22902549
8.
The cyclophilin inhibitor SCY-635 disrupts hepatitis C virus NS5A-cyclophilin A complexes.
Antimicrob Agents Chemother
; 56(7): 3888-97, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22585215
9.
Sublimable C5A delivery provides sustained and prolonged anti-HIV microbicidal activities.
Antimicrob Agents Chemother
; 56(6): 3336-43, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22430971
10.
Multiple mutations in hepatitis C virus NS5A domain II are required to confer a significant level of resistance to alisporivir.
Antimicrob Agents Chemother
; 56(10): 5113-21, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22802259
11.
Preclinical characterization of naturally occurring polyketide cyclophilin inhibitors from the sanglifehrin family.
Antimicrob Agents Chemother
; 55(5): 1975-81, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21383094
12.
Hepatitis C virus NS5A anchor peptide disrupts human immunodeficiency virus.
Proc Natl Acad Sci U S A
; 105(14): 5525-30, 2008 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-18378908
13.
The isomerase active site of cyclophilin A is critical for hepatitis C virus replication.
J Biol Chem
; 284(25): 16998-17005, 2009 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-19380579
14.
HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors.
J Hepatol
; 53(1): 50-6, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20451281
15.
Syndecan-Fc hybrid molecule as a potent in vitro microbicidal anti-HIV-1 agent.
Antimicrob Agents Chemother
; 54(7): 2753-66, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20439611
16.
Cyclophilin A-independent recruitment of NS5A and NS5B into hepatitis C virus replication complexes.
J Gen Virol
; 91(Pt 5): 1189-93, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20107018
17.
Structural mapping of CD134 residues critical for interaction with feline immunodeficiency virus.
Nat Struct Mol Biol
; 12(1): 60-6, 2005 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-15592478
18.
Syndecan-3 is a dendritic cell-specific attachment receptor for HIV-1.
Proc Natl Acad Sci U S A
; 104(49): 19464-9, 2007 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-18040049
19.
The inhibitor of apoptosis proteins antagonist Debio 1143 promotes the PD-1 blockade-mediated HIV load reduction in blood and tissues of humanized mice.
PLoS One
; 15(1): e0227715, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-31978106
20.
The cyclophilin inhibitor CRV431 inhibits liver HBV DNA and HBsAg in transgenic mice.
PLoS One
; 14(6): e0217433, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31181107