Detalhe da pesquisa
1.
Discovery and anti-tumor activity of 4-(benzylamino)-6-(3,5-dimethylisoxazol-4-yl)quinolin-2(1H)-one (CG13250), a potent, selective and orally bioavailable BET bromodomain inhibitor.
Bioorg Med Chem Lett
; 86: 129220, 2023 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36905966
2.
Optimization of a small-molecule Lipid II binder.
Bioorg Med Chem Lett
; 29(14): 1849-1853, 2019 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31126852
3.
Discovery of Mcl-1 inhibitors based on a thiazolidine-2,4-dione scaffold.
Bioorg Med Chem Lett
; 28(3): 523-528, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29329659
4.
Kröhnke pyridines: Rapid and facile access to Mcl-1 inhibitors.
Bioorg Med Chem Lett
; 28(10): 1949-1953, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29705141
5.
Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain.
Proc Natl Acad Sci U S A
; 112(17): 5455-60, 2015 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25870276
6.
CG13250, a novel bromodomain inhibitor, suppresses proliferation of multiple myeloma cells in an orthotopic mouse model.
Biochem Biophys Res Commun
; 484(2): 262-268, 2017 03 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28115161
7.
Synthetic, structural mimetics of the ß-hairpin flap of HIV-1 protease inhibit enzyme function.
Bioorg Med Chem
; 23(21): 7095-109, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26474665
8.
Pharmacophore identification of c-Myc inhibitor 10074-G5.
Bioorg Med Chem Lett
; 23(1): 370-4, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23177256
9.
Structural modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that improve selectivity for inhibiting the proliferation of melanoma cells containing active ERK signaling.
Org Biomol Chem
; 11(22): 3706-32, 2013 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23624850
10.
Discovery of N-sulfonylated aminosalicylic acids as dual MCL-1/BCL-xL inhibitors.
RSC Med Chem
; 14(1): 103-112, 2023 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36760746
11.
The Bivalent Bromodomain Inhibitor MT-1 Inhibits Prostate Cancer Growth.
Cancers (Basel)
; 15(15)2023 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37568667
12.
Anti-HIV-1 activity of resveratrol derivatives and synergistic inhibition of HIV-1 by the combination of resveratrol and decitabine.
Bioorg Med Chem Lett
; 22(21): 6642-6, 2012 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23010273
13.
3JC48-3 (methyl 4'-methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1'-biphenyl]-3-carboxylate): a novel MYC/MAX dimerization inhibitor reduces prostate cancer growth.
Cancer Gene Ther
; 29(11): 1550-1557, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35440696
14.
Optimization of a Benzothiazole Indolene Scaffold Targeting Bacterial Cell Wall Assembly.
Drug Des Devel Ther
; 14: 567-574, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32103898
15.
Nanotherapy delivery of c-myc inhibitor targets Protumor Macrophages and preserves Antitumor Macrophages in Breast Cancer.
Theranostics
; 10(17): 7510-7526, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32685002
16.
Erratum: Disruption of Myc-Max Heterodimerization with Improved Cell-Penetrating Analogs of the Small Molecule 10074-G5.
Oncotarget
; 9(80): 35196, 2018 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30416689
17.
Structure-based design of N-substituted 1-hydroxy-4-sulfamoyl-2-naphthoates as selective inhibitors of the Mcl-1 oncoprotein.
Eur J Med Chem
; 113: 273-92, 2016 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26985630
18.
Structure-activity exploration of a small-molecule Lipid II inhibitor.
Drug Des Devel Ther
; 9: 2383-94, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25987836
19.
Discovery of methyl 4'-methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1'-biphenyl]-3-carboxylate, an improved small-molecule inhibitor of c-Myc-max dimerization.
ChemMedChem
; 9(10): 2274-2285, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24976143
20.
Disruption of Myc-Max heterodimerization with improved cell-penetrating analogs of the small molecule 10074-G5.
Oncotarget
; 4(6): 936-47, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23801058