Detalhe da pesquisa
1.
Discovery of quinazoline HPK1 inhibitors with high cellular potency.
Bioorg Med Chem
; 92: 117423, 2023 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37531921
2.
Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects.
J Chem Inf Model
; 60(11): 5457-5474, 2020 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32813975
3.
Synthesis and SAR development of quinoline analogs as novel P2X7 receptor antagonists.
Bioorg Med Chem Lett
; 29(13): 1660-1664, 2019 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31031055
4.
Trends in Neosubstrate Degradation by Cereblon-Based Molecular Glues and the Development of Novel Multiparameter Optimization Scores.
J Med Chem
; 67(2): 1327-1335, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38170610
5.
Electrostatic docking of a supramolecular host-guest assembly to cytochrome c probed by bidirectional photoinduced electron transfer.
J Am Chem Soc
; 132(46): 16423-31, 2010 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-21038913
6.
Target validation using chemical probes.
Nat Chem Biol
; 9(4): 195-9, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23508172
7.
Discovery of a class of potent gap-junction modifiers as novel antiarrhythmic agents.
Bioorg Med Chem Lett
; 19(16): 4551-4, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19616941
8.
Arylphthalazines as potent, and orally bioavailable inhibitors of VEGFR-2.
Bioorg Med Chem
; 17(2): 731-40, 2009 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19101155
9.
Synthesis and evaluation of heteroaryl-ketone derivatives as a novel class of VEGFR-2 inhibitors.
Bioorg Med Chem Lett
; 18(15): 4344-7, 2008 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18640036
10.
Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain.
J Med Chem
; 60(13): 5349-5363, 2017 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28375629
11.
Structure-Based Approach To Identify 5-[4-Hydroxyphenyl]pyrrole-2-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators.
J Med Chem
; 60(14): 6451-6457, 2017 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28696695
12.
Perturbation of cellular proteostasis networks identifies pathways that modulate precursor and intermediate but not mature levels of frataxin.
Sci Rep
; 5: 18251, 2015 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26671574
13.
Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities.
Chem Biol
; 22(12): 1588-96, 2015 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26670081
14.
1-(2-Hydroxy-2-methyl-3-phenoxypropanoyl)indoline-4-carbonitrile derivatives as potent and tissue selective androgen receptor modulators.
J Med Chem
; 57(6): 2462-71, 2014 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24527807
15.
Discovery of Dual VEGFR-2 and Tubulin Inhibitors with in Vivo Efficacy.
ACS Med Chem Lett
; 1(9): 488-92, 2010 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900236
16.
Antitumor Activity of IMC-038525, a Novel Oral Tubulin Polymerization Inhibitor.
Transl Oncol
; 3(5): 318-25, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20885894