Detalhe da pesquisa
1.
Metabolomic Profiling and Drug Interaction Characterization Reveal Riboflavin As a Breast Cancer Resistance Protein-Specific Endogenous Biomarker That Demonstrates Prediction of Transporter Activity In Vivo.
Drug Metab Dispos
; 51(7): 851-861, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37055191
2.
Evaluation of Encequidar as An Intestinal P-gp and BCRP Specific Inhibitor to Assess the Role of Intestinal P-gp and BCRP in Drug-Drug Interactions.
Pharm Res
; 40(11): 2567-2584, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37523014
3.
Repression of Organic Anion Transporting Polypeptide (OATP) 1B Expression and Increase of Plasma Coproporphyrin Level as Evidence for OATP1B Downregulation in Cynomolgus Monkeys Treated with Chenodeoxycholic Acid.
Drug Metab Dispos
; 50(8): 1077-1086, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35636769
4.
Absence of OATP1B (Organic Anion-Transporting Polypeptide) Induction by Rifampin in Cynomolgus Monkeys: Determination Using the Endogenous OATP1B Marker Coproporphyrin and Tissue Gene Expression.
J Pharmacol Exp Ther
; 375(1): 139-151, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32719071
5.
Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies.
Bioorg Med Chem Lett
; 30(21): 127495, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32798651
6.
Linking (Pyr)1apelin-13 pharmacokinetics to efficacy: Stabilization and measurement of a high clearance peptide in rodents.
Anal Biochem
; 568: 41-50, 2019 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30605634
7.
Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase.
Bioorg Med Chem Lett
; 29(15): 1918-1921, 2019 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31176700
8.
Peptic Ulcer Is the Most Common Cause of Non-Variceal Upper-Gastrointestinal Bleeding (NVUGIB) in China.
Med Sci Monit
; 24: 7119-7129, 2018 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30291716
9.
[Chemical constituents from petroleum ether fraction of Swertia chirayita and their activities in vitro].
Zhongguo Zhong Yao Za Zhi
; 42(19): 3764-3769, 2017 Oct.
Artigo
em Zh
| MEDLINE | ID: mdl-29235293
10.
Electrochemical fabrication and interfacial charge-transfer process of Ni/GaN(0001) electrodes.
Phys Chem Chem Phys
; 18(8): 6032-6, 2016 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26841153
11.
Corrigendum to "Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase" [Bioorg. Med. Chem. Lett. 29 (2019) 1918-1921].
Bioorg Med Chem Lett
; 29(17): 2525, 2019 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31353296
12.
Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent.
Bioorg Med Chem Lett
; 24(5): 1294-8, 2014 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24513044
13.
The protective effect of recombinant Lactococcus lactis oral vaccine on a Clostridium difficile-infected animal model.
BMC Gastroenterol
; 13: 117, 2013 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-23865596
14.
Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1H-pyrazol-1-yl)methyl)phosphonate (BMS-820132).
J Med Chem
; 65(5): 4291-4317, 2022 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35179904
15.
Exposure to Pb, Cd, and As mixtures potentiates the production of oxidative stress precursors: 30-day, 90-day, and 180-day drinking water studies in rats.
Toxicol Appl Pharmacol
; 254(2): 154-66, 2011 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21034764
16.
In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure.
Circ Heart Fail
; 14(3): e007351, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33663236
17.
Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate.
J Med Chem
; 64(6): 3086-3099, 2021 03 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33689340
18.
Magnesium lithospermate B dilates mesenteric arteries by activating BKCa currents and contracts arteries by inhibiting K(V) currents.
Acta Pharmacol Sin
; 31(6): 665-70, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20453873
19.
[The characteristics of decomposition and nutrient release of Vicia villosa under different fertilization treatments.] / ä¸åæ½è¥æ¡ä»¶ä¸æ¯å¶èåçè 解åå »åéæ¾ç¹å¾.
Ying Yong Sheng Tai Xue Bao
; 30(7): 2275-2283, 2019 Jul.
Artigo
em Zh
| MEDLINE | ID: mdl-31418230
20.
Long-term follow-up of auditory performance and speech perception and effects of age on cochlear implantation in children with pre-lingual deafness.
Chin Med J (Engl)
; 132(16): 1925-1934, 2019 Aug 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31365431