Detalhe da pesquisa
1.
Ligand-accelerated non-directed C-H functionalization of arenes.
Nature
; 551(7681): 489-493, 2017 11 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29168802
2.
Overcoming Limitations in Decarboxylative Arylation via Ag-Ni Electrocatalysis.
J Am Chem Soc
; 144(38): 17709-17720, 2022 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36106767
3.
Mechanism of hepatobiliary toxicity of the LPA1 antagonist BMS-986020 developed to treat idiopathic pulmonary fibrosis: Contrasts with BMS-986234 and BMS-986278.
Toxicol Appl Pharmacol
; 438: 115885, 2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35090952
4.
Catalytic Ring Expansions of Cyclic Alcohols Enabled by Proton-Coupled Electron Transfer.
J Am Chem Soc
; 141(22): 8752-8757, 2019 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31117664
5.
Ligand-Promoted Borylation of C(sp(3))-H Bonds with Palladium(II) Catalysts.
Angew Chem Int Ed Engl
; 55(2): 785-9, 2016 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26611496
6.
Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists.
Bioorg Med Chem Lett
; 25(6): 1196-205, 2015 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25686852
7.
Utilization of the Zucker Diabetic Fatty (ZDF) Rat Model for Investigating Hypoglycemia-related Toxicities.
Toxicol Pathol
; 43(6): 825-37, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26085543
8.
Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases.
J Med Chem
; 64(21): 15549-15581, 2021 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34709814
9.
Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation.
Bioorg Med Chem Lett
; 20(9): 2933-7, 2010 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20356736
10.
Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.
Bioorg Med Chem Lett
; 19(5): 1451-6, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19201606
11.
Design, synthesis, and structure-activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARalpha/gamma agonists.
Bioorg Med Chem Lett
; 18(12): 3545-50, 2008 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18511276
12.
Discovery of azetidinone acids as conformationally-constrained dual PPARalpha/gamma agonists.
Bioorg Med Chem Lett
; 18(6): 1939-44, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18291645
13.
Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180).
J Med Chem
; 50(24): 5890-3, 2007 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-17973363
14.
Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist.
ACS Med Chem Lett
; 7(6): 590-4, 2016 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27326332
15.
Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor alpha/gamma dual agonist with efficacious glucose and lipid-lowering activities.
J Med Chem
; 48(6): 2248-50, 2005 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-15771468
16.
PPARs as targets for metabolic and cardiovascular diseases.
Mini Rev Med Chem
; 5(8): 741-53, 2005 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16101410
17.
Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).
J Med Chem
; 53(7): 2854-64, 2010 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-20218621
18.
A rapid, homogeneous, fluorescence polarization binding assay for peroxisome proliferator-activated receptors alpha and gamma using a fluorescein-tagged dual PPARalpha/gamma activator.
Anal Biochem
; 363(2): 263-74, 2007 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17335769
19.
Discovery, synthesis, and structure-activity studies of tetrazole based growth hormone secretagogues.
Bioorg Med Chem Lett
; 17(21): 5928-33, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17869100
20.
Discovery of tertiary aminoacids as dual PPARalpha/gamma agonists-I.
Bioorg Med Chem Lett
; 17(8): 2312-6, 2007 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17292606