Detalhe da pesquisa
1.
NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation.
Biophys J
; 108(6): 1400-1413, 2015 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25809253
2.
External protons destabilize the activated voltage sensor in hERG channels.
Eur Biophys J
; 43(2-3): 59-69, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24362825
3.
ShakerIR and Kv1.5 mutant channels with enhanced slow inactivation also exhibit K⺠o-dependent resting inactivation.
Pflugers Arch
; 465(11): 1545-55, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23708835
4.
Targeted activation of human ether-à-go-go-related gene channels rescues electrical instability induced by the R56Q+/- long QT syndrome variant.
Cardiovasc Res
; 119(15): 2522-2535, 2023 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37739930
5.
Proton block of the pore underlies the inhibition of hERG cardiac K+ channels during acidosis.
Am J Physiol Cell Physiol
; 302(12): C1797-806, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22517356
6.
CRISPR-Cas9-mediated Precise Knock-in Edits in Zebrafish Hearts.
J Vis Exp
; (187)2022 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36190280
7.
Kinetic analysis of the effects of H+ or Ni2+ on Kv1.5 current shows that both ions enhance slow inactivation and induce resting inactivation.
J Physiol
; 588(Pt 16): 3011-30, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20581043
8.
Extracellular protons accelerate hERG channel deactivation by destabilizing voltage sensor relaxation.
J Gen Physiol
; 151(2): 231-246, 2019 02 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30530765
9.
Functional interactions of voltage sensor charges with an S2 hydrophobic plug in hERG channels.
J Gen Physiol
; 142(3): 289-303, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23980197
10.
Voltage-dependent gating of HERG potassium channels.
Front Pharmacol
; 3: 83, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22586397