Detalhe da pesquisa
1.
Antiplatelet Effects of Selected Xanthine-Based Adenosine A2A and A2B Receptor Antagonists Determined in Rat Blood.
Int J Mol Sci
; 24(17)2023 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37686188
2.
In silico and in vitro ADME-Tox analysis and in vivo pharmacokinetic study of representative pan-PDE inhibitors from the group of 7,8-disubstituted derivatives of 1,3-dimethyl-7H-purine-2,6-dione.
Toxicol Appl Pharmacol
; 457: 116318, 2022 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36414119
3.
Estimation of the lipophilicity of purine-2,6-dione-based TRPA1 antagonists and PDE4/7 inhibitors with analgesic activity.
Bioorg Med Chem Lett
; 49: 128318, 2021 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34391892
4.
Synthesis and in vitro evaluation of anti-inflammatory, antioxidant, and anti-fibrotic effects of new 8-aminopurine-2,6-dione-based phosphodiesterase inhibitors as promising anti-asthmatic agents.
Bioorg Chem
; 117: 105409, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34749117
5.
Correction to: Comparative Assessment of the New PDE7 Inhibitor - GRMS-55 and Lisofylline in Animal Models of Immune-Related Disorders: A PK/PD Modeling Approach.
Pharm Res
; 37(3): 37, 2020 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31965335
6.
Comparative Assessment of the New PDE7 Inhibitor - GRMS-55 and Lisofylline in Animal Models of Immune-Related Disorders: A PK/PD Modeling Approach.
Pharm Res
; 37(2): 19, 2020 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31899535
7.
A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-ß Signaling and Activation of cAMP/PKA Signaling.
Int J Mol Sci
; 21(11)2020 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32503342
8.
Determination of ligand efficiency indices in a group of 7H-purine-2,6-dione derivatives with psychotropic activity using micellar electrokinetic chromatography.
Electrophoresis
; 39(19): 2446-2453, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30051931
9.
STUDIES OF NEW PURINE DERIVATIVES WITH ACETIC ACID MOIETY IN HUMAN KERATINOCYTES.
Acta Pol Pharm
; 74(1): 111-117, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-29474767
10.
Arylpiperazinylalkyl derivatives of 8-amino-1,3-dimethylpurine-2,6-dione as novel multitarget 5-HT/D receptor agents with potential antipsychotic activity.
J Enzyme Inhib Med Chem
; 31(6): 1048-62, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26406608
11.
Aminoalkyl Derivatives of 8-Alkoxypurine-2,6-diones: Multifunctional 5-HT1A /5-HT7 Receptor Ligands and PDE Inhibitors with Antidepressant Activity.
Arch Pharm (Weinheim)
; 349(12): 889-903, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27869315
12.
Structure-5-HT/D2 Receptor Affinity Relationship in a New Group of 1-Arylpiperazynylalkyl Derivatives of 8-Dialkylamino-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione.
Arch Pharm (Weinheim)
; 349(10): 774-784, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27510801
13.
ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIVITY OF 8-METHOXY-1,3-DIMETHYL-2,6-DIOXO-PURIN-7-YL DERIVATIVES WITH TERMINAL CARBOXYLIC, ESTER OR AMIDE MOIETIES IN ANIMAL MODELS.
Acta Pol Pharm
; 73(3): 761-70, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27476295
14.
Antidepressant- and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1,3-dimethyl-purine-2,6-dione derivatives with diversified 5-HT1A receptor functional profile.
Bioorg Med Chem
; 23(1): 212-21, 2015 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25435254
15.
Structure-5-HT receptor affinity relationship in a new group of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-amino-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione.
Arch Pharm (Weinheim)
; 348(4): 229-41, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25773578
16.
New arylpiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and dihydro[1,3]oxazolo[2,3-f]purinedione targeting the serotonin 5-HT1A /5-HT2A /5-HT7 and dopamine D2 receptors.
Arch Pharm (Weinheim)
; 348(4): 242-53, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25773907
17.
THE EFFECT OF SEROTONIN 5-HT1A, 5-HT2 RECEPTOR LIGANDS, KETOPROFEN AND THEIR COMBINATION IN MODELS OF INDUCED PAIN IN MICE.
Acta Pol Pharm
; 72(3): 579-85, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26642666
18.
Inhaled pan-phosphodiesterase inhibitors ameliorate ovalbumin-induced airway inflammation and remodeling in murine model of allergic asthma.
Int Immunopharmacol
; 119: 110264, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-37159965
19.
Pharmacokinetic/Pharmacodynamic Evaluation of a New Purine-2,6-Dione Derivative in Rodents with Experimental Autoimmune Diseases.
Pharmaceutics
; 14(5)2022 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35631676
20.
Pan-Phosphodiesterase Inhibitors Attenuate TGF-ß-Induced Pro-Fibrotic Phenotype in Alveolar Epithelial Type II Cells by Downregulating Smad-2 Phosphorylation.
Pharmaceuticals (Basel)
; 15(4)2022 Mar 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-35455420