Detalhe da pesquisa
1.
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.
Proc Natl Acad Sci U S A
; 108(11): 4400-5, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21300861
2.
In vivo activity of aryl ozonides against Schistosoma species.
Antimicrob Agents Chemother
; 56(2): 1090-2, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22106214
3.
The structure and antimalarial activity of dispiro-1,2,4,5-tetraoxanes derived from (+)-dihydrocarvone.
Bioorg Med Chem Lett
; 20(22): 6359-61, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20943385
4.
Praziquantel analogs with activity against juvenile Schistosoma mansoni.
Bioorg Med Chem Lett
; 20(8): 2481-4, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20303754
5.
The comparative antimalarial properties of weak base and neutral synthetic ozonides.
Bioorg Med Chem Lett
; 20(2): 563-6, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19962893
6.
Identification of an antimalarial synthetic trioxolane drug development candidate.
Nature
; 430(7002): 900-4, 2004 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-15318224
7.
Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity.
Bioorg Med Chem Lett
; 19(16): 4542-5, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19616946
8.
Histopathological changes in adult Schistosoma japonicum harbored in mice treated with a single dose of mefloquine.
Parasitol Res
; 104(6): 1407-16, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19221797
9.
Effect of single-dose oral mefloquine on the morphology of adult Schistosoma japonicum in mice.
Parasitol Res
; 105(3): 853-61, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19458964
10.
Malaria-infected mice are cured by oral administration of new artemisinin derivatives.
J Med Chem
; 51(4): 1035-42, 2008 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-18232653
11.
Spiro- and dispiro-1,2-dioxolanes: contribution of iron(II)-mediated one-electron vs two-electron reduction to the activity of antimalarial peroxides.
J Med Chem
; 50(23): 5840-7, 2007 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17949067
12.
Elimination of Schistosoma mansoni in infected mice by slow release of artemisone.
Int J Parasitol Drugs Drug Resist
; 7(2): 241-247, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28511056
13.
Structure-Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439).
J Med Chem
; 60(7): 2654-2668, 2017 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28052200
14.
Effect of artemether administered alone or in combination with praziquantel to mice infected with Plasmodium berghei or Schistosoma mansoni or both.
Int J Parasitol
; 36(8): 957-64, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16750833
15.
Triclabendazole and its two main metabolites lack activity against Schistosoma mansoni in the mouse model.
Am J Trop Med Hyg
; 75(2): 287-91, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16896134
16.
Ultrastructural alterations of adult schistosoma haematobium harbored in mice following artemether administration.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi
; 24(5): 321-8, 2006 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17361808
17.
Effect of artemether on the tegument of adult Schistosoma haematobium recovered from mice.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi
; 24(6): 425-32, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17366971
18.
Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.
J Med Chem
; 48(15): 4953-61, 2005 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-16033274
19.
Triggering of high-level resistance against Schistosoma mansoni reinfection by artemether in the mouse model.
Am J Trop Med Hyg
; 71(6): 774-7, 2004 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-15642970
20.
Randomized, double-blind, placebo-controlled trial of oral artemether for the prevention of patent Schistosoma haematobium infections.
Am J Trop Med Hyg
; 68(1): 24-32, 2003 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-12556143