1.
J Org Chem
; 87(21): 14846-14854, 2022 Nov 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36239694
RESUMO
In the presence of trimethylsilyl trifluoromethanesulfonate (TMSOTf) and 2,6-lutidine, α,α-disubstituted aldehydes condense with electron-rich aromatic aldehydes to yield ß,ß-disubstituted styrenes. More electron-rich aromatic aldehydes react more rapidly and in higher yield. Preliminary results suggest that the reaction may proceed via the ionization and formal deformylation of an aldol intermediate.