RESUMO
Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma, primary cutaneous CD30 lymphoproliferative disorders (pc CD30 LPD) being the second most prevalent. There is evidence that MF and pc CD30 LPD may coexist and share T-cell clonality, suggesting a common origin. These findings were supported by a T-cell receptor clonality assessment by the polymerase chain reaction coupled with capillary electrophoresis, although results produced by this method may be ambiguous. We describe an otherwise healthy 46-year-old man who developed, over the course of 5 months, a tumor consisting of primary cutaneous anaplastic large cell lymphoma and, subsequently, several papules of lymphomatoid papulosis (LyP). Both lymphomas appeared on a single patch of MF, which had been present on the patient's right buttock for at least 2 years. T-cell receptor clonality of the 3 types of neoplastic lesions and apparently non-involved skin were assessed by a next-generation sequencing-based method. We found that MF, primary cutaneous anaplastic large cell lymphoma and LyP harbored the same top 2 clones. Non-involved skin harbored other T-cell clones. In this patient, these findings suggest that MF, LyP and pc CD30 LPD were different clinicopathological manifestations arising from the neoplastic proliferation of the same T-cell clone.
Assuntos
Linfoma Anaplásico de Células Grandes/patologia , Papulose Linfomatoide/patologia , Micose Fungoide/patologia , Neoplasias Primárias Múltiplas/patologia , Neoplasias Cutâneas/patologia , Humanos , Antígeno Ki-1 , Masculino , Pessoa de Meia-Idade , Linfócitos T/patologiaRESUMO
Erythema multiforme is exceptional in newborns, and none of the few available reports has revealed a clear etiologic agent, not even herpes simplex virus. Immunocompetent patients rarely present with cutaneous cytomegalovirus involvement, and few cases of cytomegalovirus-associated erythema multiforme have been described, none of them in newborns. We report the first case of erythema multiforme in a newborn associated with cytomegalovirus infection.
Assuntos
Infecções por Citomegalovirus/complicações , Eritema Multiforme/virologia , Dermatoses do Pé/virologia , Dermatoses da Mão/virologia , Infecções por Citomegalovirus/imunologia , Infecções por Citomegalovirus/patologia , Eritema Multiforme/imunologia , Eritema Multiforme/patologia , Feminino , Dermatoses do Pé/imunologia , Dermatoses do Pé/patologia , Dermatoses da Mão/imunologia , Dermatoses da Mão/patologia , Humanos , Imunocompetência , Recém-NascidoRESUMO
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