DW4TR: A Data Warehouse for Translational Research.

The linkage between the clinical and laboratory research domains is a key issue in translational research. Integration of clinicopathologic data alone is a major task given the number of data elements involved. For a translational research environment, it is critical to make these data usable at the point-of-need. Individual systems have been developed to meet the needs of particular projects though the need for a generalizable system has been recognized. Increased use of Electronic Medical Record data in translational research will demand generalizing the system for integrating clinical data to support the study of a broad range of human diseases. To ultimately satisfy these needs, we have developed a system to support multiple translational research projects. This system, the Data Warehouse for Translational Research (DW4TR), is based on a light-weight, patient-centric modularly-structured clinical data model and a specimen-centric molecular data model. The temporal relationships of the data are also part of the model. The data are accessed through an interface composed of an Aggregated Biomedical-Information Browser (ABB) and an Individual Subject Information Viewer (ISIV) which target general users. The system was developed to support a breast cancer translational research program and has been extended to support a gynecological disease program. Further extensions of the DW4TR are underway. We believe that the DW4TR will play an important role in translational research across multiple disease types.

An Examination of Personality Traits Associated with Autonomous Sensory Meridian Response (ASMR).

Autonomous Sensory Meridian Response (ASMR) is a perceptual condition in which the presentation of particular audio-visual stimuli triggers intense, pleasurable tingling sensations in the head and neck regions, which may spread to the periphery of the body. These triggering stimuli are often socially intimate in nature, and usually involve repetition of movements and/or sounds (e.g., hearing whispering, watching someone brush her hair). Reports of ASMR experiences first appeared in online communities in 2010; since this time, these communities have expanded, with some groups consisting of over 100,000 members. However, despite the apparent prevalence of ASMR, there is currently no research on the personality characteristics that co-occur with this condition. In the current study, 290 individuals with ASMR and 290 matched controls completed the Big Five Personality Inventory (BFI; John et al., 1991); participants with ASMR also completed a questionnaire related to their ASMR phenomenology. Individuals with ASMR demonstrated significantly higher scores on Openness-to-Experience and Neuroticism, and significantly lower levels of Conscientiousness, Extraversion, and Agreeableness compared to matched controls. Further, ratings of subjective ASMR intensity in response to 14 common ASMR stimuli were positively correlated with the Openness-to-Experience and Neuroticism dimensions of the BFI. These results provide preliminary evidence that ASMR is associated with specific personality traits and suggest avenues for further investigation.

Plasmodial incompatibility in the myxomycete Didymium squamulosum.

A genetic analysis of plasmodial fusion in the CR 10 isolate of Didymium squamulosum indicated that this isolate was heterozygous for two fusion loci. These loci display dominant and recessive alleles, and any two plasmodia must be phenotypically identical for these loci before they will fuse.

Culture and reproductive systems of 11 species of Mycetozoans.

The culture and reproductive systems of 10 species (16 isolates) of myxomycetes and one species (one isolate) of protostelid were investigated. A single isolate of Ceratiomyxa fructiculosa was grown on agar and found to be nonheterothallic. This is the first report of spore-to-spore cultivation of this species and the first report of a reproductive system in the protostelids. Isolates of the myxomycetes Didymium dubium, Didymium iridis, Didymium vaccinum, Licea biforis, Perichaena vermicularis, Physarum gyrosum, Physarum pusillum (six isolates) and Semimorula liquescens all were nonheterothallic. This is the first report of culture and a reproductive system for D. vaccinum, the first report of nonheterothallism for S. liquescens and the second report of nonheterothallic isolates of D. dubium, Licea biforis, Perichaena vermicularis and P. gyrosum. The nonheterothallic isolate of D. iridis is one of many reported for this species, and the six nonheterothallic isolates of P. pusillum add to the seven nonheterothallic and two heterothallic isolates already known. In addition, five of the isolates of P. pusillum apparently represent a small form that is adapted to an ephemeral micohabitat, and the sixth is a yellow form of a species that is typically white. The Didymium ?ovoideum isolate and the two Physarum didermoides isolates have heterothallic reproductive systems. The D. ?ovoideum isolate is somewhat different from most isolates of this species in its morphology and reproductive system. It is not compatible with any of the heterothallic isolates of long-stalked Didymium, including the A0 biological species already determined for D. ovoideum; therefore, it is either a new biological species of D. ovoideum or a separate new species. The two heterothallic isolates of P. didermoides form a multiple allelic mating-type series with four alleles.

Biosystematics of the myxomycete Badhamia gracilis.

Sixty-four isolates that conformed to the general morphological description of Badhamia gracilis were isolated from several arid regions in the southwestern USA, northern Mexico, Puerto Rico, and the Canary Islands. These isolates were then subjected to a biosystematic study in which reproductive systems, culture characteristics, and morphology were examined. Five of the isolates were heterothallic and were divided into two separate biological species with multiple allelic mating systems: A1 consisting of three isolates (Arz 4, Arz 5, Arz 6) displaying four alleles, and A2 consisting of two isolates (NM 3, NM 4) also displaying four alleles. The remaining 59 isolates were nonheterothallic and presumably apomictic. All of the isolates had similar culture characteristics in that they had white (rarely with a yellowish tinge) plasmodia that sporulated at a relatively small size. While all of the isolates generally conformed to the standard species description, there were several variations from the norm that occurred at a high frequency. The sporotheca was often laterally flattened instead of globose or ovate, the spores generally averaged 10 µm instead of 14 µm in diam, and the capillitium often appeared physaroid instead of badhamoid. This study indicates that Badhamia gracilis is probably a widespread species complex consisting of a number of local sexual populations and numerous asexual clones that are adapted to arid conditions.

The effects of dictyostelids on the formation and maturation of myxomycete plasmodia.

Dictyostelids (cellular slime molds) and myxomycetes (plasmodial slime molds) are two groups of mycetozoans usually present and often abundant in the soil and litter microhabitats of terrestrial ecosystems. Because they utilize the same food resource and occur together in a spatially limited and clearly defined microhabitat, the potential for ecological interactions would seem to exist. However, relatively few previous studies have considered this aspect of mycetozoan ecology. In the present study twenty-eight isolates (8 species) of dictyostelids were co-cultured in all possible pair-wise combinations with fourteen isolates (7 species) of myxomycetes to determine if there were any effects on the production of fruiting bodies. Dictyostelids showed little or no delay in culmination and only random and inconsistent reductions in sorocarp abundance when co-cultured with myxomycetes. In contrast, myxomycetes displayed a number of specific effects. The heterothallic isolates exhibited delays in plasmodial formation and/or maturation, with some pairings showing little to no effect, while others displayed nearly complete inhibition of plasmodial formation or maturation. Apomictic isolates, in general, were much less affected, with only a few combinations displaying significant delays in both formation and maturation of plasmodia.

Appropriately upset? Emotion norms and perceptions of crime victims.

Victims who express less emotion in response to a crime are perceived as less deserving, less sympathetic, and they have less punishment assigned to the offender who committed the crime. This study considers the extent to which emotion norms underlie perceptions of victims who testify. Two studies investigate the circumstances in which emotional reactions to a crime are seen as "unusual" and whether a more general emotion norm underlies responses to victim testimony. We test a "victim-role" norm against a "proportionality" norm by crossing the severity of victim's emotional response (severe or mild) with the seriousness of a crime (serious or less serious). Results across two studies lend greater support to the notion that people expect victims to match the intensity of their emotional response to the seriousness of the event (i.e., a proportionality rule), although we also find instances in which expectations of the victim are not strong. Gender of the victim exhibited small and contingent effects. We discuss the relevance of emotion norms to legal settings.