Pesquisa | Biblioteca Virtual em Saúde

1.

p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003.

Taylor, Lewis W; Simzer, Elizabeth M; Pimblett, Claire; Lacey-Solymar, Oscar T T; McGeachan, Robert I; Meftah, Soraya; Rose, Jamie L; Spires-Jones, Maxwell P; Holt, Kristján; Catterson, James H; Koch, Henner; Liaquat, Imran; Clarke, Jonathan H; Skidmore, John; Smith, Colin; Booker, Sam A; Brennan, Paul M; Spires-Jones, Tara L; Durrant, Claire S.

Acta Neuropathol ; 147(1): 7, 2024 Jan 04.

Artigo em Inglês | MEDLINE | ID: mdl-38175261

2.

PI(5)P regulates autophagosome biogenesis.

Vicinanza, Mariella; Korolchuk, Viktor I; Ashkenazi, Avraham; Puri, Claudia; Menzies, Fiona M; Clarke, Jonathan H; Rubinsztein, David C.

Mol Cell ; 57(2): 219-34, 2015 Jan 22.

Artigo em Inglês | MEDLINE | ID: mdl-25578879

3.

In B cells, phosphatidylinositol 5-phosphate 4-kinase-α synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling.

Bulley, Simon J; Droubi, Alaa; Clarke, Jonathan H; Anderson, Karen E; Stephens, Len R; Hawkins, Phillip T; Irvine, Robin F.

Proc Natl Acad Sci U S A ; 113(38): 10571-6, 2016 09 20.

Artigo em Inglês | MEDLINE | ID: mdl-27601656

4.

Nuclear localizations of phosphatidylinositol 5-phosphate 4-kinases α and ß are dynamic and independently regulated during starvation-induced stress.

Droubi, Alaa; Bulley, Simon J; Clarke, Jonathan H; Irvine, Robin F.

Biochem J ; 473(14): 2155-63, 2016 07 15.

Artigo em Inglês | MEDLINE | ID: mdl-27208178

5.

The function of phosphatidylinositol 5-phosphate 4-kinase Î³ (PI5P4KÎ³) explored using a specific inhibitor that targets the PI5P-binding site.

Clarke, Jonathan H; Giudici, Maria-Luisa; Burke, John E; Williams, Roger L; Maloney, David J; Marugan, Juan; Irvine, Robin F.

Biochem J ; 466(2): 359-67, 2015 Mar 01.

Artigo em Inglês | MEDLINE | ID: mdl-25495341

6.

Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates TOR signaling and cell growth during Drosophila development.

Gupta, Amit; Toscano, Sarah; Trivedi, Deepti; Jones, David R; Mathre, Swarna; Clarke, Jonathan H; Divecha, Nullin; Raghu, Padinjat.

Proc Natl Acad Sci U S A ; 110(15): 5963-8, 2013 Apr 09.

Artigo em Inglês | MEDLINE | ID: mdl-23530222

7.

Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization.

Clarke, Jonathan H; Irvine, Robin F.

Biochem J ; 454(1): 49-57, 2013 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-23758345

8.

The Identification of Potent, Selective, and Brain Penetrant PI5P4KÎ³ Inhibitors as In Vivo-Ready Tool Molecules.

Rooney, Timothy P C; Aldred, Gregory G; Boffey, Helen K; Willems, Henriëtte M G; Edwards, Simon; Chawner, Stephen J; Scott, Duncan E; Green, Christopher; Winpenny, David; Skidmore, John; Clarke, Jonathan H; Andrews, Stephen P.

J Med Chem ; 66(1): 804-821, 2023 01 12.

Artigo em Inglês | MEDLINE | ID: mdl-36516442

9.

Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor.

Willems, Henriëtte M G; Edwards, Simon; Boffey, Helen K; Chawner, Stephen J; Green, Christopher; Romero, Tamara; Winpenny, David; Skidmore, John; Clarke, Jonathan H; Andrews, Stephen P.

RSC Med Chem ; 14(5): 934-946, 2023 May 25.

Artigo em Inglês | MEDLINE | ID: mdl-37252102

10.

The rational design of ARUK2007145, a dual inhibitor of the α and Î³ isoforms of the lipid kinase phosphatidylinositol 5-phosphate 4-kinase (PI5P4K).

Aldred, Gregory G; Rooney, Timothy P C; Willems, Henriette M G; Boffey, Helen K; Green, Christopher; Winpenny, David; Skidmore, John; Clarke, Jonathan H; Andrews, Stephen P.

RSC Med Chem ; 14(10): 2035-2047, 2023 Oct 18.

Artigo em Inglês | MEDLINE | ID: mdl-37859710

11.

Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase Î³ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode.

Boffey, Helen K; Rooney, Timothy P C; Willems, Henriette M G; Edwards, Simon; Green, Christopher; Howard, Tina; Ogg, Derek; Romero, Tamara; Scott, Duncan E; Winpenny, David; Duce, James; Skidmore, John; Clarke, Jonathan H; Andrews, Stephen P.

J Med Chem ; 65(4): 3359-3370, 2022 02 24.

Artigo em Inglês | MEDLINE | ID: mdl-35148092

12.

Genomic tagging reveals a random association of endogenous PtdIns5P 4-kinases IIalpha and IIbeta and a partial nuclear localization of the IIalpha isoform.

Wang, Minchuan; Bond, Nicholas J; Letcher, Andrew J; Richardson, Jonathan P; Lilley, Kathryn S; Irvine, Robin F; Clarke, Jonathan H.

Biochem J ; 430(2): 215-21, 2010 Sep 01.

Artigo em Inglês | MEDLINE | ID: mdl-20569199

13.

Systematic Investigation of the Permeability of Androgen Receptor PROTACs.

Scott, Duncan E; Rooney, Timothy P C; Bayle, Elliott D; Mirza, Tashfina; Willems, Henriette M G; Clarke, Jonathan H; Andrews, Stephen P; Skidmore, John.

ACS Med Chem Lett ; 11(8): 1539-1547, 2020 Aug 13.

Artigo em Inglês | MEDLINE | ID: mdl-32832021

14.

Genomic tagging of endogenous type IIbeta phosphatidylinositol 5-phosphate 4-kinase in DT40 cells reveals a nuclear localisation.

Richardson, Jonathan P; Wang, Minchuan; Clarke, Jonathan H; Patel, Ketan J; Irvine, R F.

Cell Signal ; 19(6): 1309-14, 2007 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-17303380

15.

Lipid signalling: picking out the PIPs.

Clarke, Jonathan H.

Curr Biol ; 13(20): R815-7, 2003 Oct 14.

Artigo em Inglês | MEDLINE | ID: mdl-14561425

16.

Type II PtdInsP kinases: location, regulation and function.

Clarke, Jonathan H; Richardson, Jonathan P; Hinchliffe, Katherine A; Irvine, Robin F.

Biochem Soc Symp ; (74): 149-59, 2007.

Artigo em Inglês | MEDLINE | ID: mdl-17233588

17.

Phosphatidylinositol 5-phosphate 4-kinase Î³ (PI5P4KÎ³), a lipid signalling enigma.

Giudici, Maria-Luisa; Clarke, Jonathan H; Irvine, Robin F.

Adv Biol Regul ; 61: 47-50, 2016 05.

Artigo em Inglês | MEDLINE | ID: mdl-26710750

18.

Effects of lipid kinase expression and cellular stimuli on phosphatidylinositol 5-phosphate levels in mammalian cell lines.

Roberts, Hilary F; Clarke, Jonathan H; Letcher, Andrew J; Irvine, Robin F; Hinchliffe, Katherine A.

FEBS Lett ; 579(13): 2868-72, 2005 May 23.

Artigo em Inglês | MEDLINE | ID: mdl-15876433

19.

Exploring phosphatidylinositol 5-phosphate 4-kinase function.

Bulley, Simon J; Clarke, Jonathan H; Droubi, Alaa; Giudici, Maria-Luisa; Irvine, Robin F.

Adv Biol Regul ; 57: 193-202, 2015 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-25311266

20.

Distribution and neuronal expression of phosphatidylinositol phosphate kinase IIgamma in the mouse brain.

Clarke, Jonathan H; Emson, Piers C; Irvine, Robin F.

J Comp Neurol ; 517(3): 296-312, 2009 Nov 20.

Artigo em Inglês | MEDLINE | ID: mdl-19757494

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